Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/823/genes/?format=api
{ "data": [ { "type": "Gene", "id": "PMS2", "attributes": { "go_molecular_function": [ "['MutSalpha complex binding', 'single-stranded DNA binding', 'ATP hydrolysis activity', 'ATP binding', 'DNA binding', 'protein binding', 'endonuclease activity', 'single base insertion or deletion binding']" ], "pathway_id": [ "kegg_path:hsa03430", "kegg_path:hsa03460", "R-HSA-1643685", "R-HSA-212436", "R-HSA-3700989", "R-HSA-5358508", "R-HSA-5358565", "R-HSA-5358606", "R-HSA-5423599", "R-HSA-5545483", "R-HSA-5632987", "R-HSA-6796648", "R-HSA-73857", "R-HSA-73894", "R-HSA-74160", "R-HSA-9675135" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P54278", "ensembl_id": "None", "entrez_id": "ENSG00000122512", "chromosome_number": "7", "lastmodified": "2022-08-04T14:14:59.486648" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3059" }, { "type": "SmallVariant", "id": "2443" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PMS2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PMS2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "823" }, { "type": "GeneCombination", "id": "1026" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PMS2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PMS2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PMS2/?format=api" } }, { "type": "Gene", "id": "POLE", "attributes": { "go_molecular_function": [ "single-stranded DNA 3'-5' exodeoxyribonuclease activity", "protein binding", "DNA-directed DNA polymerase activity", "4 iron, 4 sulfur cluster binding", "DNA binding", "nucleotide binding", "chromatin binding", "zinc ion binding" ], "pathway_id": [ "R-HSA-453279", "R-HSA-6781827", "R-HSA-73884", "R-HSA-5656169", "R-HSA-5696397", "R-HSA-73933", "R-HSA-69278", "R-HSA-73894", "R-HSA-5696398", "R-HSA-69239", "R-HSA-5693538", "R-HSA-69242", "kegg_path:hsa03420", "R-HSA-5696399", "R-HSA-5693567", "kegg_path:hsa03030", "R-HSA-69002", "R-HSA-110373", "R-HSA-110314", "R-HSA-5693532", "R-HSA-69206", "R-HSA-68962", "R-HSA-110313", "R-HSA-6782135", "R-HSA-68952", "R-HSA-5651801", "R-HSA-73893", "R-HSA-5696400", "R-HSA-6782210", "R-HSA-1640170", "R-HSA-69306", "kegg_path:hsa03410", "R-HSA-5685942" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q07864", "ensembl_id": "ENSG00000177084", "entrez_id": "5426", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:58.293972" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2249" }, { "type": "SmallVariant", "id": "2444" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLE/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLE/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "759" }, { "type": "GeneCombination", "id": "823" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLE/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLE/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POLE/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }