Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/587/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GBE1", "attributes": { "go_molecular_function": [ "carbohydrate binding", "1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)", "1,4-alpha-glucan branching enzyme activity", "protein binding" ], "pathway_id": [ "R-HSA-71387", "R-HSA-1430728", "R-HSA-3322077", "kegg_path:hsa01100", "R-HSA-5663084", "R-HSA-3878781", "R-HSA-1643685", "R-HSA-8982491", "kegg_path:hsa00500", "R-HSA-3229121", "R-HSA-5668914" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q04446", "ensembl_id": "ENSG00000114480", "entrez_id": "2632", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.529170" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1738" }, { "type": "SmallVariant", "id": "1776" }, { "type": "SmallVariant", "id": "1779" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GBE1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GBE1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "573" }, { "type": "GeneCombination", "id": "587" }, { "type": "GeneCombination", "id": "588" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GBE1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GBE1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GBE1/?format=api" } }, { "type": "Gene", "id": "HMBS", "attributes": { "go_molecular_function": [ "hydroxymethylbilane synthase activity", "protein binding", "transferase activity" ], "pathway_id": [ "kegg_path:hsa00860", "kegg_path:hsa01100", "R-HSA-189445", "R-HSA-189451", "R-HSA-1430728", "kegg_path:hsa01240" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P08397", "ensembl_id": "ENSG00000256269", "entrez_id": "3145", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.253957" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "335" }, { "type": "SmallVariant", "id": "1775" }, { "type": "SmallVariant", "id": "1781" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HMBS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HMBS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "118" }, { "type": "GeneCombination", "id": "587" }, { "type": "GeneCombination", "id": "589" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HMBS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HMBS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HMBS/?format=api" } }, { "type": "Gene", "id": "PHKA1", "attributes": { "go_molecular_function": [ "protein binding", "calmodulin binding", "phosphorylase kinase activity" ], "pathway_id": [ "kegg_path:hsa04922", "R-HSA-1430728", "R-HSA-71387", "kegg_path:hsa04922", "R-HSA-1430728", "R-HSA-71387", "R-HSA-8982491", "kegg_path:hsa04910", "R-HSA-70221", "R-HSA-8982491", "kegg_path:hsa04910", "R-HSA-70221", "kegg_path:hsa04020", "kegg_path:hsa04020" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P46020", "ensembl_id": "ENSG00000067177", "entrez_id": "5255", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.444743" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1778" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PHKA1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PHKA1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "587" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PHKA1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PHKA1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PHKA1/?format=api" } }, { "type": "Gene", "id": "RYR1", "attributes": { "go_molecular_function": [ "['calcium-induced calcium release activity', 'calcium channel activity', 'ATP binding', 'calcium ion binding', 'ryanodine-sensitive calcium-release channel activity', 'calcium-release channel activity', 'calmodulin binding', 'voltage-gated calcium channel activity']" ], "pathway_id": [ "kegg_path:hsa04020", "kegg_path:hsa04371", "kegg_path:hsa04713", "kegg_path:hsa04730", "kegg_path:hsa04921", "kegg_path:hsa05017", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-2672351", "R-HSA-382551", "R-HSA-397014", "R-HSA-5576891", "R-HSA-5578775", "R-HSA-983712" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P21817", "ensembl_id": "None", "entrez_id": "ENSG00000196218", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.725464" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1777" }, { "type": "SmallVariant", "id": "3077" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RYR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RYR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "587" }, { "type": "GeneCombination", "id": "1032" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RYR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RYR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RYR1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }