Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1082/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FGFR3", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity', 'protein binding', 'fibroblast growth factor-activated receptor activity', 'fibroblast growth factor binding', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04550", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05206", "kegg_path:hsa05219", "kegg_path:hsa05230", "R-HSA-1226099", "R-HSA-1643685", "R-HSA-1839130", "R-HSA-2033514", "R-HSA-2033515", "R-HSA-5655332", "R-HSA-5663202", "R-HSA-8853334", "R-HSA-8853338", "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04550", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05206", "kegg_path:hsa05219", "kegg_path:hsa05230" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P22607", "ensembl_id": "None", "entrez_id": "ENSG00000068078", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.500473" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1152" }, { "type": "SmallVariant", "id": "3209" }, { "type": "SmallVariant", "id": "3276" }, { "type": "SmallVariant", "id": "3333" }, { "type": "SmallVariant", "id": "3700" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "369" }, { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1124" }, { "type": "GeneCombination", "id": "1252" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/?format=api" } }, { "type": "Gene", "id": "FLRT3", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'protein-macromolecule adaptor activity', 'protein binding', 'fibroblast growth factor receptor binding', 'chemorepellent activity']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-162582", "R-HSA-190236", "R-HSA-376176", "R-HSA-422475", "R-HSA-5654687", "R-HSA-5654736", "R-HSA-9006934", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NZU0", "ensembl_id": "None", "entrez_id": "ENSG00000125848", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.905326" }, "relationships": { "variant_set": { "meta": { "count": 11 }, "data": [ { "type": "SmallVariant", "id": "805" }, { "type": "SmallVariant", "id": "806" }, { "type": "SmallVariant", "id": "815" }, { "type": "SmallVariant", "id": "2682" }, { "type": "SmallVariant", "id": "2695" }, { "type": "SmallVariant", "id": "2730" }, { "type": "SmallVariant", "id": "3194" }, { "type": "SmallVariant", "id": "3225" }, { "type": "SmallVariant", "id": "3234" }, { "type": "SmallVariant", "id": "3258" }, { "type": "SmallVariant", "id": "3474" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLRT3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLRT3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "252" }, { "type": "GeneCombination", "id": "256" }, { "type": "GeneCombination", "id": "897" }, { "type": "GeneCombination", "id": "909" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1079" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1094" }, { "type": "GeneCombination", "id": "1166" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLRT3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLRT3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FLRT3/?format=api" } }, { "type": "Gene", "id": "GHR", "attributes": { "go_molecular_function": [ "['peptide hormone binding', 'proline-rich region binding', 'SH2 domain binding', 'growth hormone receptor activity', 'protein kinase binding', 'cytokine binding', 'protein phosphatase binding', 'protein binding', 'growth factor binding', 'protein homodimerization activity', 'cytokine receptor activity', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04080", "kegg_path:hsa04151", "kegg_path:hsa04630", "kegg_path:hsa04935", "R-HSA-1170546", "R-HSA-1280215", "R-HSA-168256", "R-HSA-982772" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10912", "ensembl_id": "None", "entrez_id": "ENSG00000112964", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.556257" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1957" }, { "type": "SmallVariant", "id": "1967" }, { "type": "SmallVariant", "id": "3219" }, { "type": "SmallVariant", "id": "3222" }, { "type": "SmallVariant", "id": "3232" }, { "type": "SmallVariant", "id": "3249" }, { "type": "SmallVariant", "id": "3269" }, { "type": "SmallVariant", "id": "3279" }, { "type": "SmallVariant", "id": "3330" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "674" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1077" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1099" }, { "type": "GeneCombination", "id": "1103" }, { "type": "GeneCombination", "id": "1123" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/?format=api" } }, { "type": "Gene", "id": "LZTR1", "attributes": { "go_molecular_function": [ "['small GTPase binding', 'protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000099949", "chromosome_number": "22", "lastmodified": "2023-05-16T12:02:32.843192" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2784" }, { "type": "SmallVariant", "id": "3233" }, { "type": "SmallVariant", "id": "3240" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LZTR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LZTR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "931" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1086" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LZTR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LZTR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LZTR1/?format=api" } }, { "type": "Gene", "id": "SHH", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'patched binding', 'laminin-1 binding', 'calcium ion binding', 'morphogen activity', 'endopeptidase activity', 'protein binding', 'glycosaminoglycan binding']" ], "pathway_id": [ "kegg_path:hsa04340", "kegg_path:hsa04360", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05217", "kegg_path:hsa05226", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373080", "R-HSA-500792", "R-HSA-5358346", "R-HSA-5358351", "R-HSA-5362768", "R-HSA-5362798", "R-HSA-5387390", "R-HSA-5632681", "R-HSA-5632684", "R-HSA-5635838", "R-HSA-5658034", "R-HSA-5663202" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15465", "ensembl_id": "None", "entrez_id": "ENSG00000164690", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.375806" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "876" }, { "type": "SmallVariant", "id": "1461" }, { "type": "SmallVariant", "id": "1475" }, { "type": "SmallVariant", "id": "1484" }, { "type": "SmallVariant", "id": "1514" }, { "type": "SmallVariant", "id": "2366" }, { "type": "SmallVariant", "id": "3130" }, { "type": "SmallVariant", "id": "3231" }, { "type": "SmallVariant", "id": "3262" }, { "type": "SmallVariant", "id": "3329" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHH/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 12 }, "data": [ { "type": "GeneCombination", "id": "273" }, { "type": "GeneCombination", "id": "467" }, { "type": "GeneCombination", "id": "472" }, { "type": "GeneCombination", "id": "475" }, { "type": "GeneCombination", "id": "486" }, { "type": "GeneCombination", "id": "1046" }, { "type": "GeneCombination", "id": "1047" }, { "type": "GeneCombination", "id": "800" }, { "type": "GeneCombination", "id": "801" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1096" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHH/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }