Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/581/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CFTR", "attributes": { "go_molecular_function": [ "intracellularly ATP-gated chloride channel activity", "ATPase-coupled transmembrane transporter activity", "protein binding", "ATP hydrolysis activity", "chloride transmembrane transporter activity", "enzyme binding", "isomerase activity", "ATPase-coupled inorganic anion transmembrane transporter activity", "Sec61 translocon complex binding", "chaperone binding", "bicarbonate transmembrane transporter activity", "chloride channel inhibitor activity", "PDZ domain binding", "chloride channel activity", "chloride channel regulator activity", "ATP binding", "ABC-type transporter activity" ], "pathway_id": [ "R-HSA-5619084", "R-HSA-5627083", "R-HSA-9615710", "R-HSA-194315", "R-HSA-162582", "R-HSA-5678895", "R-HSA-9663891", "kegg_path:hsa04976", "kegg_path:hsa04976", "R-HSA-597592", "kegg_path:hsa04152", "kegg_path:hsa05110", "kegg_path:hsa04152", "kegg_path:hsa05110", "kegg_path:hsa04024", "kegg_path:hsa04024", "R-HSA-195258", "R-HSA-9613829", "R-HSA-5619115", "R-HSA-5653656", "R-HSA-8856828", "kegg_path:hsa04971", "kegg_path:hsa04971", "R-HSA-5688426", "R-HSA-382551", "kegg_path:hsa04530", "kegg_path:hsa04972", "kegg_path:hsa04530", "kegg_path:hsa04972", "R-HSA-382556", "R-HSA-9646399", "R-HSA-8856825", "kegg_path:hsa02010", "kegg_path:hsa02010", "R-HSA-1643685", "R-HSA-392499", "R-HSA-1632852", "R-HSA-199991", "R-HSA-9612973", "R-HSA-5689880" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P13569", "ensembl_id": "ENSG00000001626", "entrez_id": "1080", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.472577" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1759" }, { "type": "SmallVariant", "id": "1761" }, { "type": "SmallVariant", "id": "1763" }, { "type": "SmallVariant", "id": "2451" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CFTR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CFTR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "580" }, { "type": "GeneCombination", "id": "581" }, { "type": "GeneCombination", "id": "582" }, { "type": "GeneCombination", "id": "827" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CFTR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CFTR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CFTR/?format=api" } }, { "type": "Gene", "id": "SERPINA1", "attributes": { "go_molecular_function": [ "protein binding", "serine-type endopeptidase inhibitor activity", "identical protein binding" ], "pathway_id": [ "R-HSA-199977", "R-HSA-597592", "R-HSA-381426", "R-HSA-168249", "R-HSA-392499", "R-HSA-114608", "R-HSA-5653656", "R-HSA-6798695", "R-HSA-204005", "R-HSA-109582", "R-HSA-199991", "R-HSA-76005", "R-HSA-948021", "R-HSA-76002", "R-HSA-8957275", "kegg_path:hsa04610", "kegg_path:hsa04610", "R-HSA-446203", "R-HSA-5694530", "R-HSA-168256" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P01009", "ensembl_id": "ENSG00000197249", "entrez_id": "5265", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.259449" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1762" }, { "type": "SmallVariant", "id": "1769" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SERPINA1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SERPINA1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "581" }, { "type": "GeneCombination", "id": "583" }, { "type": "GeneCombination", "id": "584" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SERPINA1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SERPINA1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SERPINA1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }