Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1204/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALDH1A2", "attributes": { "go_molecular_function": [ "['aldehyde dehydrogenase (NAD+) activity', 'retinal dehydrogenase activity', 'retinal binding', '3-chloroallyl aldehyde dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00830", "kegg_path:hsa01100", "R-HSA-162582", "R-HSA-5362517", "R-HSA-5365859", "R-HSA-9006931" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O94788", "ensembl_id": "None", "entrez_id": "ENSG00000128918", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.353012" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1602" }, { "type": "SmallVariant", "id": "3577" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1A2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALDH1A2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "515" }, { "type": "GeneCombination", "id": "1204" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1A2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALDH1A2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1A2/?format=api" } }, { "type": "Gene", "id": "CDHR1", "attributes": { "go_molecular_function": [ "['molecular_function', 'calcium ion binding']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "A0A0A6YYA3", "ensembl_id": "None", "entrez_id": "ENSG00000148600", "chromosome_number": "10", "lastmodified": "2024-02-29T15:02:20.550920" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3544" }, { "type": "SmallVariant", "id": "3552" }, { "type": "SmallVariant", "id": "3578" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDHR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDHR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1193" }, { "type": "GeneCombination", "id": "1195" }, { "type": "GeneCombination", "id": "1204" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDHR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDHR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CDHR1/?format=api" } }, { "type": "Gene", "id": "LRP1B", "attributes": { "go_molecular_function": [ "['calcium ion binding', 'protein binding', 'low-density lipoprotein particle receptor activity']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NZR2", "ensembl_id": "None", "entrez_id": "ENSG00000168702", "chromosome_number": "2", "lastmodified": "2023-05-16T12:02:32.849547" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "2786" }, { "type": "SmallVariant", "id": "2787" }, { "type": "SmallVariant", "id": "3572" }, { "type": "SmallVariant", "id": "3576" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP1B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP1B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "932" }, { "type": "GeneCombination", "id": "1203" }, { "type": "GeneCombination", "id": "1204" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP1B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP1B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LRP1B/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }