Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/472/genes/?format=api
{ "data": [ { "type": "Gene", "id": "BOC", "attributes": { "go_molecular_function": [ "protein binding" ], "pathway_id": [ "R-HSA-5632681", "R-HSA-5358351", "R-HSA-162582", "R-HSA-5632684", "kegg_path:hsa04360", "kegg_path:hsa04340", "R-HSA-5635838" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9BWV1", "ensembl_id": "ENSG00000144857", "entrez_id": "91653", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.798184" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1472" }, { "type": "SmallVariant", "id": "1476" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BOC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BOC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "471" }, { "type": "GeneCombination", "id": "472" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BOC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BOC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BOC/?format=api" } }, { "type": "Gene", "id": "SCUBE2", "attributes": { "go_molecular_function": [ "['lipid binding', 'calcium ion binding', 'protein binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-5358346", "R-HSA-5358351", "R-HSA-5362798" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9NQ36", "ensembl_id": "None", "entrez_id": "ENSG00000175356", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.941425" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1473" }, { "type": "SmallVariant", "id": "1477" }, { "type": "SmallVariant", "id": "1839" }, { "type": "SmallVariant", "id": "2742" }, { "type": "SmallVariant", "id": "2743" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCUBE2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCUBE2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "471" }, { "type": "GeneCombination", "id": "472" }, { "type": "GeneCombination", "id": "609" }, { "type": "GeneCombination", "id": "913" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCUBE2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCUBE2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SCUBE2/?format=api" } }, { "type": "Gene", "id": "SHH", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'patched binding', 'laminin-1 binding', 'calcium ion binding', 'morphogen activity', 'endopeptidase activity', 'protein binding', 'glycosaminoglycan binding']" ], "pathway_id": [ "kegg_path:hsa04340", "kegg_path:hsa04360", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05217", "kegg_path:hsa05226", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373080", "R-HSA-500792", "R-HSA-5358346", "R-HSA-5358351", "R-HSA-5362768", "R-HSA-5362798", "R-HSA-5387390", "R-HSA-5632681", "R-HSA-5632684", "R-HSA-5635838", "R-HSA-5658034", "R-HSA-5663202" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15465", "ensembl_id": "None", "entrez_id": "ENSG00000164690", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.375806" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "876" }, { "type": "SmallVariant", "id": "1461" }, { "type": "SmallVariant", "id": "1475" }, { "type": "SmallVariant", "id": "1484" }, { "type": "SmallVariant", "id": "1514" }, { "type": "SmallVariant", "id": "2366" }, { "type": "SmallVariant", "id": "3130" }, { "type": "SmallVariant", "id": "3231" }, { "type": "SmallVariant", "id": "3262" }, { "type": "SmallVariant", "id": "3329" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHH/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 12 }, "data": [ { "type": "GeneCombination", "id": "273" }, { "type": "GeneCombination", "id": "467" }, { "type": "GeneCombination", "id": "472" }, { "type": "GeneCombination", "id": "475" }, { "type": "GeneCombination", "id": "486" }, { "type": "GeneCombination", "id": "1046" }, { "type": "GeneCombination", "id": "1047" }, { "type": "GeneCombination", "id": "800" }, { "type": "GeneCombination", "id": "801" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1096" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHH/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/?format=api" } }, { "type": "Gene", "id": "STK36", "attributes": { "go_molecular_function": [ "protein binding", "transferase activity", "kinase activity", "ATP binding", "protein serine/threonine kinase activity", "nucleotide binding", "protein kinase activity", "metal ion binding", "protein serine kinase activity" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NRP7", "ensembl_id": "ENSG00000163482", "entrez_id": "27148", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.307720" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1478" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STK36/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STK36/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "472" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STK36/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STK36/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/STK36/?format=api" } }, { "type": "Gene", "id": "WNT4", "attributes": { "go_molecular_function": [ "['transcription corepressor activity', 'frizzled binding', 'receptor ligand activity', 'cytokine activity']" ], "pathway_id": [ "kegg_path:hsa04150", "kegg_path:hsa04310", "kegg_path:hsa04360", "kegg_path:hsa04390", "kegg_path:hsa04550", "kegg_path:hsa04916", "kegg_path:hsa04919", "kegg_path:hsa04934", "kegg_path:hsa05010", "kegg_path:hsa05022", "kegg_path:hsa05165", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05217", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "R-HSA-162582", "R-HSA-195721", "R-HSA-201681", "R-HSA-3238698", "R-HSA-372790", "R-HSA-373080", "R-HSA-3772470", "R-HSA-3858494", "R-HSA-4086400", "R-HSA-500792" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P56705", "ensembl_id": "None", "entrez_id": "ENSG00000162552", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.277654" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1479" }, { "type": "SmallVariant", "id": "2455" }, { "type": "SmallVariant", "id": "2457" }, { "type": "SmallVariant", "id": "2607" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WNT4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WNT4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "472" }, { "type": "GeneCombination", "id": "828" }, { "type": "GeneCombination", "id": "829" }, { "type": "GeneCombination", "id": "864" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WNT4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WNT4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/WNT4/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }