Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/543/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GAPDH", "attributes": { "go_molecular_function": [ "oxidoreductase activity", "protein binding", "transferase activity", "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "identical protein binding" ], "pathway_id": [ "kegg_path:hsa01200", "R-HSA-70171", "kegg_path:hsa05130", "kegg_path:hsa00010", "kegg_path:hsa01100", "kegg_path:hsa04066", "kegg_path:hsa05132", "R-HSA-70263", "kegg_path:hsa05010", "R-HSA-71387", "kegg_path:hsa01230", "R-HSA-1430728", "R-HSA-70326" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P04406", "ensembl_id": "ENSG00000111640", "entrez_id": "2597", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.821428" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1668" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GAPDH/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GAPDH/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "543" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GAPDH/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GAPDH/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GAPDH/?format=api" } }, { "type": "Gene", "id": "ROR2", "attributes": { "go_molecular_function": [ "['Wnt-protein binding', 'mitogen-activated protein kinase kinase kinase binding', 'ATP binding', 'frizzled binding', 'protein binding', 'metal ion binding', 'coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa04310", "R-HSA-162582", "R-HSA-195721", "R-HSA-3858494", "R-HSA-4086400", "R-HSA-5140745" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q01974", "ensembl_id": "None", "entrez_id": "ENSG00000169071", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.743625" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1531" }, { "type": "SmallVariant", "id": "1664" }, { "type": "SmallVariant", "id": "1669" }, { "type": "SmallVariant", "id": "3288" }, { "type": "SmallVariant", "id": "3313" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ROR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ROR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "491" }, { "type": "GeneCombination", "id": "541" }, { "type": "GeneCombination", "id": "543" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ROR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ROR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ROR2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }