Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1087/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AKR1C3", "attributes": { "go_molecular_function": [ "['geranylgeranyl reductase activity', '15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity', 'ketosteroid monooxygenase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'androsterone dehydrogenase activity', '17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'ketoreductase activity', 'steroid dehydrogenase activity', 'D-threo-aldose 1-dehydrogenase activity', 'oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor', 'prostaglandin-F synthase activity', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'dihydrotestosterone 17-beta-dehydrogenase activity', 'phenanthrene 9,10-monooxygenase activity', 'prostaglandin H2 endoperoxidase reductase activity', 'delta4-3-oxosteroid 5beta-reductase activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'NAD-retinol dehydrogenase activity', 'bile acid binding', 'alditol:NADP+ 1-oxidoreductase activity', 'retinal dehydrogenase activity', 'NADP-retinol dehydrogenase activity', 'testosterone dehydrogenase (NAD+) activity', 'prostaglandin D2 11-ketoreductase activity', 'aldo-keto reductase (NADP) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2142753", "R-HSA-2162123", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-5362517", "R-HSA-5365859", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-8978868", "R-HSA-9006931", "R-HSA-975634", "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2142753", "R-HSA-2162123", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-5362517", "R-HSA-5365859", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-8978868", "R-HSA-9006931", "R-HSA-975634" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P42330", "ensembl_id": "None", "entrez_id": "ENSG00000196139", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.479228" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1200" }, { "type": "SmallVariant", "id": "3220" }, { "type": "SmallVariant", "id": "3245" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1087" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C3/?format=api" } }, { "type": "Gene", "id": "AKR1C4", "attributes": { "go_molecular_function": [ "['electron transfer activity', 'ketosteroid monooxygenase activity', 'chlordecone reductase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'androsterone dehydrogenase activity', '17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'steroid dehydrogenase activity', 'D-threo-aldose 1-dehydrogenase activity', 'oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'dihydrotestosterone 17-beta-dehydrogenase activity', 'bile acid transmembrane transporter activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'bile acid binding', 'alditol:NADP+ 1-oxidoreductase activity', 'retinal dehydrogenase activity', 'testosterone dehydrogenase (NAD+) activity', 'aldo-keto reductase (NADP) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00120", "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-975634", "kegg_path:hsa00120", "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-975634" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P17516", "ensembl_id": "None", "entrez_id": "ENSG00000198610", "chromosome_number": "10", "lastmodified": "2023-05-16T12:02:33.621158" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3228" }, { "type": "SmallVariant", "id": "3244" }, { "type": "SmallVariant", "id": "3291" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1079" }, { "type": "GeneCombination", "id": "1087" }, { "type": "GeneCombination", "id": "1107" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C4/?format=api" } }, { "type": "Gene", "id": "FANCD2", "attributes": { "go_molecular_function": [ "['DNA polymerase binding', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa03460", "R-HSA-212436", "R-HSA-3700989", "R-HSA-6783310", "R-HSA-6796648", "R-HSA-73857", "R-HSA-73894", "R-HSA-74160" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9BXW9", "ensembl_id": "None", "entrez_id": "ENSG00000144554", "chromosome_number": "3", "lastmodified": "2023-05-16T12:02:33.533469" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "3172" }, { "type": "SmallVariant", "id": "3242" }, { "type": "SmallVariant", "id": "3243" }, { "type": "SmallVariant", "id": "3327" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FANCD2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FANCD2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "1059" }, { "type": "GeneCombination", "id": "1071" }, { "type": "GeneCombination", "id": "1087" }, { "type": "GeneCombination", "id": "1121" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FANCD2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FANCD2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FANCD2/?format=api" } }, { "type": "Gene", "id": "RNF216", "attributes": { "go_molecular_function": [ "['ubiquitin protein ligase activity', 'protein binding', 'metal ion binding']" ], "pathway_id": [ "R-HSA-168249", "R-HSA-168256", "R-HSA-168928", "R-HSA-936440" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9NWF9", "ensembl_id": "None", "entrez_id": "ENSG00000011275", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.917313" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "36" }, { "type": "SmallVariant", "id": "586" }, { "type": "SmallVariant", "id": "773" }, { "type": "SmallVariant", "id": "1799" }, { "type": "SmallVariant", "id": "2933" }, { "type": "SmallVariant", "id": "2978" }, { "type": "SmallVariant", "id": "3198" }, { "type": "SmallVariant", "id": "3238" }, { "type": "SmallVariant", "id": "3246" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RNF216/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RNF216/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "14" }, { "type": "GeneCombination", "id": "203" }, { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "596" }, { "type": "GeneCombination", "id": "974" }, { "type": "GeneCombination", "id": "993" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1087" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RNF216/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RNF216/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RNF216/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }