Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/540/genes/?format=api
{ "data": [ { "type": "Gene", "id": "DVL1", "attributes": { "go_molecular_function": [ "protein binding", "enzyme binding", "frizzled binding" ], "pathway_id": [ "kegg_path:hsa04934", "R-HSA-9673324", "R-HSA-194315", "kegg_path:hsa04550", "kegg_path:hsa05165", "R-HSA-5368598", "R-HSA-5663205", "R-HSA-3858494", "R-HSA-4641258", "kegg_path:hsa04916", "kegg_path:hsa05022", "R-HSA-195258", "R-HSA-9658195", "kegg_path:hsa05200", "kegg_path:hsa04330", "R-HSA-162582", "kegg_path:hsa04310", "R-HSA-195721", "kegg_path:hsa04390", "R-HSA-4086400", "R-HSA-5663220", "kegg_path:hsa05010", "kegg_path:hsa04150", "R-HSA-201688", "kegg_path:hsa05224", "kegg_path:hsa05217", "R-HSA-1643685", "R-HSA-9664420", "kegg_path:hsa05225", "kegg_path:hsa05226", "R-HSA-201681", "R-HSA-4641262" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O14640", "ensembl_id": "ENSG00000107404", "entrez_id": "1855", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.455015" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1619" }, { "type": "SmallVariant", "id": "1645" }, { "type": "SmallVariant", "id": "1660" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DVL1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DVL1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "521" }, { "type": "GeneCombination", "id": "534" }, { "type": "GeneCombination", "id": "540" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DVL1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DVL1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DVL1/?format=api" } }, { "type": "Gene", "id": "NID1", "attributes": { "go_molecular_function": [ "laminin binding", "extracellular matrix binding", "laminin-1 binding", "extracellular matrix structural constituent", "collagen binding" ], "pathway_id": [ "R-HSA-1474228", "R-HSA-1474244", "R-HSA-3000157" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P14543", "ensembl_id": "ENSG00000116962", "entrez_id": "4811", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.306679" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1589" }, { "type": "SmallVariant", "id": "1637" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NID1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NID1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "530" }, { "type": "GeneCombination", "id": "540" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NID1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NID1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NID1/?format=api" } }, { "type": "Gene", "id": "SETD2", "attributes": { "go_molecular_function": [ "protein binding", "histone methyltransferase activity (H3-K36 specific)", "protein-lysine N-methyltransferase activity", "alpha-tubulin binding", "histone-lysine N-methyltransferase activity" ], "pathway_id": [ "R-HSA-4839726", "R-HSA-3214841", "kegg_path:hsa01100", "kegg_path:hsa00310", "R-HSA-3247509" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9BYW2", "ensembl_id": "ENSG00000181555", "entrez_id": "29072", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.783115" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1661" }, { "type": "SmallVariant", "id": "1547" }, { "type": "SmallVariant", "id": "1622" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETD2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETD2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "496" }, { "type": "GeneCombination", "id": "522" }, { "type": "GeneCombination", "id": "540" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETD2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETD2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SETD2/?format=api" } }, { "type": "Gene", "id": "SHROOM1", "attributes": { "go_molecular_function": [ "actin filament binding", "myosin II binding", "actin binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q2M3G4", "ensembl_id": "ENSG00000164403", "entrez_id": "134549", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.716488" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1567" }, { "type": "SmallVariant", "id": "1572" }, { "type": "SmallVariant", "id": "1582" }, { "type": "SmallVariant", "id": "1662" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "503" }, { "type": "GeneCombination", "id": "505" }, { "type": "GeneCombination", "id": "509" }, { "type": "GeneCombination", "id": "540" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }