Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/778/genes/?format=api
{ "data": [ { "type": "Gene", "id": "KMT2D", "attributes": { "go_molecular_function": [ "['DNA binding', 'histone binding', 'protein binding', 'transcription cis-regulatory region binding', 'transcription coactivator activity', 'histone methyltransferase activity (H3-K4 specific)', 'metal ion binding']" ], "pathway_id": [ "kegg_path:hsa00310", "kegg_path:hsa01100", "kegg_path:hsa04934", "R-HSA-1266738", "R-HSA-162582", "R-HSA-195721", "R-HSA-201681", "R-HSA-201722", "R-HSA-212436", "R-HSA-3214841", "R-HSA-3247509", "R-HSA-3769402", "R-HSA-4839726", "R-HSA-5617472", "R-HSA-5619507", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878171", "R-HSA-8936459" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O14686", "ensembl_id": "None", "entrez_id": "ENSG00000167548", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:59.900296" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "2315" }, { "type": "SmallVariant", "id": "3388" }, { "type": "SmallVariant", "id": "3392" }, { "type": "SmallVariant", "id": "3394" }, { "type": "SmallVariant", "id": "3652" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2D/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT2D/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "778" }, { "type": "GeneCombination", "id": "1135" }, { "type": "GeneCombination", "id": "1136" }, { "type": "GeneCombination", "id": "1137" }, { "type": "GeneCombination", "id": "1229" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2D/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT2D/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2D/?format=api" } }, { "type": "Gene", "id": "NBN", "attributes": { "go_molecular_function": [ "DNA-binding transcription factor binding", "protein N-terminus binding", "damaged DNA binding", "protein binding" ], "pathway_id": [ "R-HSA-2559586", "R-HSA-5693538", "R-HSA-5693567", "R-HSA-5685939", "R-HSA-69620", "R-HSA-5693537", "R-HSA-1474165", "R-HSA-5693571", "R-HSA-5693565", "R-HSA-5693568", "R-HSA-2559583", "R-HSA-5693579", "R-HSA-69473", "R-HSA-73894", "R-HSA-6804756", "R-HSA-5633007", "R-HSA-5693554", "R-HSA-5693607", "R-HSA-5693548", "R-HSA-69481", "kegg_path:hsa04218", "R-HSA-212436", "R-HSA-3700989", "R-HSA-5685942", "kegg_path:hsa03440", "R-HSA-1640170", "R-HSA-2262752", "R-HSA-5693606", "R-HSA-74160", "R-HSA-912446", "R-HSA-5685938", "R-HSA-5693532", "R-HSA-5693616", "R-HSA-8953897", "R-HSA-1500620", "R-HSA-73857" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60934", "ensembl_id": "ENSG00000104320", "entrez_id": "4683", "chromosome_number": "8", "lastmodified": "2022-08-04T14:14:59.575244" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2316" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NBN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NBN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "778" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NBN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NBN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NBN/?format=api" } }, { "type": "Gene", "id": "SAMD11", "attributes": { "go_molecular_function": [ "chromatin binding", "histone binding", "protein binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96NU1", "ensembl_id": "ENSG00000187634", "entrez_id": "148398", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:59.520075" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2266" }, { "type": "SmallVariant", "id": "2340" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SAMD11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SAMD11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "762" }, { "type": "GeneCombination", "id": "765" }, { "type": "GeneCombination", "id": "774" }, { "type": "GeneCombination", "id": "778" }, { "type": "GeneCombination", "id": "787" }, { "type": "GeneCombination", "id": "790" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SAMD11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SAMD11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SAMD11/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }