Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/217/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALOX15", "attributes": { "go_molecular_function": [ "linoleate 13S-lipoxygenase activity", "protein binding", "arachidonate 15-lipoxygenase activity", "arachidonate 12(S)-lipoxygenase activity", "iron ion binding", "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "phosphatidylinositol-4,5-bisphosphate binding" ], "pathway_id": [ "R-HSA-9023661", "R-HSA-9025106", "kegg_path:hsa04217", "R-HSA-168256", "kegg_path:hsa00591", "kegg_path:hsa04216", "R-HSA-8978868", "R-HSA-9026286", "kegg_path:hsa01100", "R-HSA-9018681", "R-HSA-2142691", "R-HSA-1280215", "R-HSA-9025094", "R-HSA-1430728", "R-HSA-9018677", "R-HSA-9018896", "R-HSA-6785807", "R-HSA-9018678", "kegg_path:hsa04726", "R-HSA-2142770", "R-HSA-9018679", "R-HSA-449147", "R-HSA-2142712", "R-HSA-2142753", "R-HSA-9018683", "R-HSA-556833", "kegg_path:hsa00590" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P16050", "ensembl_id": "ENSG00000161905", "entrez_id": "246", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.509598" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "645" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALOX15/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALOX15/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "217" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALOX15/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALOX15/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALOX15/?format=api" } }, { "type": "Gene", "id": "AR", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'transcription cis-regulatory region binding', 'nuclear receptor activity', 'steroid binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'DNA-binding transcription factor activity', 'POU domain binding', 'androgen binding', 'transcription coactivator binding', 'chromatin binding', 'ATPase binding', 'beta-catenin binding', 'RNA polymerase II general transcription initiation factor binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'enzyme binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'signaling receptor binding']" ], "pathway_id": [ "kegg_path:hsa04114", "kegg_path:hsa05200", "kegg_path:hsa05215", "R-HSA-162582", "R-HSA-194315", "R-HSA-195258", "R-HSA-212436", "R-HSA-2262752", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-3371497", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-5625740", "R-HSA-5625886", "R-HSA-5688426", "R-HSA-5689880", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8940973", "R-HSA-8941326", "R-HSA-8953897" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P10275", "ensembl_id": "None", "entrez_id": "ENSG00000169083", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.665425" }, "relationships": { "variant_set": { "meta": { "count": 15 }, "data": [ { "type": "SmallVariant", "id": "580" }, { "type": "CopyNumberVariant", "id": "2184" }, { "type": "SmallVariant", "id": "646" }, { "type": "SmallVariant", "id": "2159" }, { "type": "SmallVariant", "id": "2164" }, { "type": "SmallVariant", "id": "2168" }, { "type": "SmallVariant", "id": "2171" }, { "type": "SmallVariant", "id": "2173" }, { "type": "SmallVariant", "id": "2175" }, { "type": "SmallVariant", "id": "2177" }, { "type": "SmallVariant", "id": "2180" }, { "type": "SmallVariant", "id": "2182" }, { "type": "SmallVariant", "id": "3248" }, { "type": "SmallVariant", "id": "3292" }, { "type": "SmallVariant", "id": "3311" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "736" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "739" }, { "type": "GeneCombination", "id": "740" }, { "type": "GeneCombination", "id": "741" }, { "type": "GeneCombination", "id": "742" }, { "type": "GeneCombination", "id": "743" }, { "type": "GeneCombination", "id": "744" }, { "type": "GeneCombination", "id": "745" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1108" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AR/?format=api" } }, { "type": "Gene", "id": "COL4A1", "attributes": { "go_molecular_function": [ "extracellular matrix structural constituent", "platelet-derived growth factor binding" ], "pathway_id": [ "R-HSA-422475", "R-HSA-375165", "R-HSA-9675108", "kegg_path:hsa04512", "kegg_path:hsa05165", "R-HSA-1474290", "R-HSA-3000157", "kegg_path:hsa05222", "R-HSA-1266738", "R-HSA-2022090", "R-HSA-3000178", "R-HSA-2243919", "kegg_path:hsa04926", "R-HSA-162582", "R-HSA-419037", "R-HSA-186797", "kegg_path:hsa04974", "kegg_path:hsa05200", "kegg_path:hsa05146", "R-HSA-1474228", "R-HSA-1442490", "R-HSA-1474244", "R-HSA-216083", "R-HSA-5653656", "kegg_path:hsa04933", "R-HSA-1650814", "R-HSA-2173782", "R-HSA-3000480", "R-HSA-8948216", "R-HSA-9006934", "kegg_path:hsa04510", "R-HSA-2214320", "kegg_path:hsa04151", "R-HSA-3000171" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P02462", "ensembl_id": "ENSG00000187498", "entrez_id": "1282", "chromosome_number": "13", "lastmodified": "2021-10-18T11:00:44.532749" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "301" }, { "type": "SmallVariant", "id": "647" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL4A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL4A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "109" }, { "type": "GeneCombination", "id": "217" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL4A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL4A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL4A1/?format=api" } }, { "type": "Gene", "id": "FBXW8", "attributes": { "go_molecular_function": [], "pathway_id": [ "R-HSA-8951664", "R-HSA-983169", "R-HSA-168256", "R-HSA-983168", "R-HSA-597592", "kegg_path:hsa04120", "R-HSA-1280218", "R-HSA-392499" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A499FIY5", "ensembl_id": "ENSG00000174989", "entrez_id": "26259", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.846752" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "648" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FBXW8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FBXW8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "217" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FBXW8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FBXW8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FBXW8/?format=api" } }, { "type": "Gene", "id": "NOB1", "attributes": { "go_molecular_function": [ "protein binding", "nuclease activity", "endonuclease activity", "hydrolase activity", "endoribonuclease activity", "metal ion binding" ], "pathway_id": [ "R-HSA-8868773", "R-HSA-8953854", "R-HSA-6791226", "R-HSA-72312", "kegg_path:hsa03008" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9ULX3", "ensembl_id": "ENSG00000141101", "entrez_id": "28987", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.796265" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "649" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOB1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOB1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "217" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOB1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOB1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOB1/?format=api" } }, { "type": "Gene", "id": "PMM2", "attributes": { "go_molecular_function": [ "['phosphomannomutase activity', 'metal ion binding', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa00051", "kegg_path:hsa00520", "kegg_path:hsa01100", "kegg_path:hsa01240", "kegg_path:hsa00051", "kegg_path:hsa00520", "kegg_path:hsa01100", "kegg_path:hsa01240", "R-HSA-1643685", "R-HSA-3781865", "R-HSA-392499", "R-HSA-4043911", "R-HSA-446193", "R-HSA-446203", "R-HSA-446205", "R-HSA-446219", "R-HSA-5609975", "R-HSA-5668914", "R-HSA-597592" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O15305", "ensembl_id": "None", "entrez_id": "ENSG00000140650", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.354107" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "650" }, { "type": "SmallVariant", "id": "1068" }, { "type": "SmallVariant", "id": "1069" }, { "type": "SmallVariant", "id": "1992" }, { "type": "SmallVariant", "id": "3685" }, { "type": "SmallVariant", "id": "3686" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PMM2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PMM2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "349" }, { "type": "GeneCombination", "id": "685" }, { "type": "GeneCombination", "id": "1245" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PMM2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PMM2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PMM2/?format=api" } }, { "type": "Gene", "id": "SOD1", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'small GTPase binding', 'superoxide dismutase activity', 'protein binding', 'protein phosphatase 2B binding', 'copper ion binding', 'chaperone binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04146", "kegg_path:hsa04213", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-109582", "R-HSA-114608", "R-HSA-1280215", "R-HSA-168256", "R-HSA-2262752", "R-HSA-3299685", "R-HSA-447115", "R-HSA-449147", "R-HSA-76002", "R-HSA-76005", "R-HSA-8950505", "R-HSA-8953897", "R-HSA-9020591" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00441", "ensembl_id": "None", "entrez_id": "ENSG00000142168", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.427208" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "1693" }, { "type": "SmallVariant", "id": "525" }, { "type": "SmallVariant", "id": "527" }, { "type": "SmallVariant", "id": "541" }, { "type": "SmallVariant", "id": "638" }, { "type": "SmallVariant", "id": "693" }, { "type": "SmallVariant", "id": "936" }, { "type": "SmallVariant", "id": "937" }, { "type": "SmallVariant", "id": "1379" }, { "type": "SmallVariant", "id": "1428" }, { "type": "SmallVariant", "id": "1709" }, { "type": "SmallVariant", "id": "2035" }, { "type": "SmallVariant", "id": "2039" }, { "type": "SmallVariant", "id": "2050" }, { "type": "SmallVariant", "id": "2189" }, { "type": "SmallVariant", "id": "3418" }, { "type": "SmallVariant", "id": "3426" }, { "type": "SmallVariant", "id": "3432" }, { "type": "SmallVariant", "id": "3446" }, { "type": "SmallVariant", "id": "3600" }, { "type": "SmallVariant", "id": "3603" }, { "type": "SmallVariant", "id": "3605" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 36 }, "data": [ { "type": "GeneCombination", "id": "173" }, { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "298" }, { "type": "GeneCombination", "id": "434" }, { "type": "GeneCombination", "id": "451" }, { "type": "GeneCombination", "id": "552" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "561" }, { "type": "GeneCombination", "id": "562" }, { "type": "GeneCombination", "id": "699" }, { "type": "GeneCombination", "id": "700" }, { "type": "GeneCombination", "id": "701" }, { "type": "GeneCombination", "id": "702" }, { "type": "GeneCombination", "id": "706" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1154" }, { "type": "GeneCombination", "id": "1158" }, { "type": "GeneCombination", "id": "1212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/?format=api" } }, { "type": "Gene", "id": "TPP1", "attributes": { "go_molecular_function": [ "protein binding", "tripeptidyl-peptidase activity", "serine-type endopeptidase activity", "sulfatide binding", "peptidase activity", "hydrolase activity", "serine-type peptidase activity", "lysophosphatidic acid binding", "endopeptidase activity", "metal ion binding" ], "pathway_id": [ "R-HSA-381119", "kegg_path:hsa04142", "R-HSA-381070", "R-HSA-392499", "R-HSA-381038" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O14773", "ensembl_id": "ENSG00000166340", "entrez_id": "1200", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.847725" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "651" }, { "type": "SmallVariant", "id": "985" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TPP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TPP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "316" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TPP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TPP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TPP1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 8 } }