Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/223/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CAPN1", "attributes": { "go_molecular_function": [ "protein binding", "hydrolase activity", "peptidase activity", "cysteine-type peptidase activity", "metal ion binding" ], "pathway_id": [ "R-HSA-6809371", "kegg_path:hsa04141", "kegg_path:hsa05010", "R-HSA-1266738", "kegg_path:hsa04218", "R-HSA-1474228", "R-HSA-6805567", "R-HSA-8863678", "R-HSA-1474244", "R-HSA-6798695", "kegg_path:hsa05022", "R-HSA-168249", "R-HSA-1643685", "kegg_path:hsa05131", "R-HSA-9645723", "kegg_path:hsa04217", "R-HSA-168256", "R-HSA-8862803", "kegg_path:hsa04210" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P07384", "ensembl_id": "ENSG00000014216", "entrez_id": "823", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.269871" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "694" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CAPN1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CAPN1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "223" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CAPN1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CAPN1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CAPN1/?format=api" } }, { "type": "Gene", "id": "CHAT", "attributes": { "go_molecular_function": [ "['choline O-acetyltransferase activity']" ], "pathway_id": [ "kegg_path:hsa00564", "kegg_path:hsa04725", "R-HSA-112310", "R-HSA-112315", "R-HSA-112316", "R-HSA-1430728", "R-HSA-1483191", "R-HSA-1483206", "R-HSA-1483257", "R-HSA-264642", "R-HSA-556833" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P28329", "ensembl_id": "None", "entrez_id": "ENSG00000070748", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.600497" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "695" }, { "type": "SmallVariant", "id": "3099" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHAT/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHAT/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "1038" }, { "type": "GeneCombination", "id": "1039" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHAT/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHAT/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CHAT/?format=api" } }, { "type": "Gene", "id": "GALC", "attributes": { "go_molecular_function": [ "galactosylceramidase activity" ], "pathway_id": [ "kegg_path:hsa00600", "kegg_path:hsa04142", "R-HSA-1430728", "R-HSA-1660662", "R-HSA-428157", "kegg_path:hsa01100", "R-HSA-556833" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P54803", "ensembl_id": "ENSG00000054983", "entrez_id": "2581", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.752228" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "677" }, { "type": "SmallVariant", "id": "696" }, { "type": "SmallVariant", "id": "1999" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GALC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GALC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "688" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GALC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GALC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GALC/?format=api" } }, { "type": "Gene", "id": "KIF1B", "attributes": { "go_molecular_function": [ "ATP binding", "nucleotide binding", "protein binding", "kinesin binding" ], "pathway_id": [ "R-HSA-109582", "R-HSA-199991", "R-HSA-5653656", "R-HSA-6811442", "R-HSA-6811434", "R-HSA-983189", "R-HSA-8856688", "R-HSA-983231" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60333", "ensembl_id": "ENSG00000054523", "entrez_id": "23095", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.747730" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "697" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KIF1B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KIF1B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "223" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KIF1B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KIF1B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KIF1B/?format=api" } }, { "type": "Gene", "id": "SOD1", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'small GTPase binding', 'superoxide dismutase activity', 'protein binding', 'protein phosphatase 2B binding', 'copper ion binding', 'chaperone binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04146", "kegg_path:hsa04213", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-109582", "R-HSA-114608", "R-HSA-1280215", "R-HSA-168256", "R-HSA-2262752", "R-HSA-3299685", "R-HSA-447115", "R-HSA-449147", "R-HSA-76002", "R-HSA-76005", "R-HSA-8950505", "R-HSA-8953897", "R-HSA-9020591" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00441", "ensembl_id": "None", "entrez_id": "ENSG00000142168", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.427208" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "1693" }, { "type": "SmallVariant", "id": "525" }, { "type": "SmallVariant", "id": "527" }, { "type": "SmallVariant", "id": "541" }, { "type": "SmallVariant", "id": "638" }, { "type": "SmallVariant", "id": "693" }, { "type": "SmallVariant", "id": "936" }, { "type": "SmallVariant", "id": "937" }, { "type": "SmallVariant", "id": "1379" }, { "type": "SmallVariant", "id": "1428" }, { "type": "SmallVariant", "id": "1709" }, { "type": "SmallVariant", "id": "2035" }, { "type": "SmallVariant", "id": "2039" }, { "type": "SmallVariant", "id": "2050" }, { "type": "SmallVariant", "id": "2189" }, { "type": "SmallVariant", "id": "3418" }, { "type": "SmallVariant", "id": "3426" }, { "type": "SmallVariant", "id": "3432" }, { "type": "SmallVariant", "id": "3446" }, { "type": "SmallVariant", "id": "3600" }, { "type": "SmallVariant", "id": "3603" }, { "type": "SmallVariant", "id": "3605" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 36 }, "data": [ { "type": "GeneCombination", "id": "173" }, { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "298" }, { "type": "GeneCombination", "id": "434" }, { "type": "GeneCombination", "id": "451" }, { "type": "GeneCombination", "id": "552" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "561" }, { "type": "GeneCombination", "id": "562" }, { "type": "GeneCombination", "id": "699" }, { "type": "GeneCombination", "id": "700" }, { "type": "GeneCombination", "id": "701" }, { "type": "GeneCombination", "id": "702" }, { "type": "GeneCombination", "id": "706" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1154" }, { "type": "GeneCombination", "id": "1158" }, { "type": "GeneCombination", "id": "1212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }