Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1063/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GPRC6A", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity']" ], "pathway_id": [ "kegg_path:hsa04621", "R-HSA-162582", "R-HSA-372790", "R-HSA-388396", "R-HSA-416476", "R-HSA-420499", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q5T6X5", "ensembl_id": "None", "entrez_id": "ENSG00000173612", "chromosome_number": "6", "lastmodified": "2023-05-16T12:02:33.486621" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "3157" }, { "type": "SmallVariant", "id": "3183" }, { "type": "SmallVariant", "id": "3186" }, { "type": "SmallVariant", "id": "3202" }, { "type": "SmallVariant", "id": "3204" }, { "type": "SmallVariant", "id": "3239" }, { "type": "SmallVariant", "id": "3312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "1053" }, { "type": "GeneCombination", "id": "1063" }, { "type": "GeneCombination", "id": "1064" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1105" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1111" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/?format=api" } }, { "type": "Gene", "id": "SOS1", "attributes": { "go_molecular_function": [ "['GTPase activator activity', 'guanyl-nucleotide exchange factor activity', 'DNA binding', 'protein heterodimerization activity', 'protein binding', 'SH3 domain binding']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa01522", "kegg_path:hsa04010", "kegg_path:hsa04012", "kegg_path:hsa04014", "kegg_path:hsa04062", "kegg_path:hsa04068", "kegg_path:hsa04072", "kegg_path:hsa04150", "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04540", "kegg_path:hsa04630", "kegg_path:hsa04650", "kegg_path:hsa04660", "kegg_path:hsa04662", "kegg_path:hsa04664", "kegg_path:hsa04714", "kegg_path:hsa04722", "kegg_path:hsa04810", "kegg_path:hsa04910", "kegg_path:hsa04912", "kegg_path:hsa04915", "kegg_path:hsa04917", "kegg_path:hsa04926", "kegg_path:hsa04935", "kegg_path:hsa05034", "kegg_path:hsa05160", "kegg_path:hsa05161", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05210", "kegg_path:hsa05211", "kegg_path:hsa05213", "kegg_path:hsa05214", "kegg_path:hsa05215", "kegg_path:hsa05220", "kegg_path:hsa05221", "kegg_path:hsa05223", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "kegg_path:hsa05231", "R-HSA-109582", "R-HSA-112399", "R-HSA-112412", "R-HSA-1226099", "R-HSA-1227986", "R-HSA-1227990", "R-HSA-1236382", "R-HSA-1236394", "R-HSA-1250196", "R-HSA-1250347", "R-HSA-1266738", "R-HSA-1280215", "R-HSA-1280218", "R-HSA-1433557", "R-HSA-1433559", "R-HSA-162582", "R-HSA-1643685", "R-HSA-1643713", "R-HSA-166520", "R-HSA-167044", "R-HSA-168249", "R-HSA-168256", "R-HSA-177929", "R-HSA-179812", "R-HSA-180336", "R-HSA-186763", "R-HSA-186797", "R-HSA-187037", "R-HSA-187687", "R-HSA-190236", "R-HSA-193648", "R-HSA-193704", "R-HSA-194315", "R-HSA-194840", "R-HSA-1963640", "R-HSA-202733", "R-HSA-204998", "R-HSA-210993", "R-HSA-2172127", "R-HSA-2179392", "R-HSA-2404192", "R-HSA-2424491", "R-HSA-2428924", "R-HSA-2428928", "R-HSA-2428933", "R-HSA-2454202", "R-HSA-2730905", "R-HSA-2871796", "R-HSA-2871809", "R-HSA-354192", "R-HSA-354194", "R-HSA-372790", "R-HSA-375165", "R-HSA-376176", "R-HSA-388396", "R-HSA-416476", "R-HSA-416482", "R-HSA-422475", "R-HSA-428540", "R-HSA-449147", "R-HSA-451927", "R-HSA-512988", "R-HSA-5637810", "R-HSA-5637812", "R-HSA-5637815", "R-HSA-5654687", "R-HSA-5654688", "R-HSA-5654693", "R-HSA-5654696", "R-HSA-5654699", "R-HSA-5654700", "R-HSA-5654704", "R-HSA-5654706", "R-HSA-5654708", "R-HSA-5654712", "R-HSA-5654716", "R-HSA-5654719", "R-HSA-5654736", "R-HSA-5654738", "R-HSA-5654741", "R-HSA-5654743", "R-HSA-5655253", "R-HSA-5655291", "R-HSA-5655302", "R-HSA-5655332", "R-HSA-5663202", "R-HSA-5673001", "R-HSA-5683057", "R-HSA-5684996", "R-HSA-6806834", "R-HSA-73887", "R-HSA-74749", "R-HSA-74751", "R-HSA-74752", "R-HSA-76002", "R-HSA-76009", "R-HSA-881907", "R-HSA-8851805", "R-HSA-8853334", "R-HSA-8853338", "R-HSA-8853659", "R-HSA-8983432", "R-HSA-9006115", "R-HSA-9006335", "R-HSA-9006934", "R-HSA-9026519", "R-HSA-9027284", "R-HSA-9028731", "R-HSA-9034015", "R-HSA-9034864", "R-HSA-912526", "R-HSA-9607240", "R-HSA-9634285", "R-HSA-9664565", "R-HSA-9665348", "R-HSA-9665686", "R-HSA-9669938", "R-HSA-9670439", "R-HSA-9671555", "R-HSA-9673767", "R-HSA-9673770", "R-HSA-9675108", "R-HSA-9682385", "R-HSA-9703465", "R-HSA-9703648", "R-HSA-983695", "R-HSA-983705" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000115904", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.520986" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1187" }, { "type": "SmallVariant", "id": "3184" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "380" }, { "type": "GeneCombination", "id": "1063" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOS1/?format=api" } }, { "type": "Gene", "id": "SRD5A2", "attributes": { "go_molecular_function": [ "['amide binding', 'testosterone dehydrogenase [NAD(P)] activity', 'protein binding', 'oxidoreductase activity', 'cholestenone 5-alpha-reductase activity', '3-oxo-5-alpha-steroid 4-dehydrogenase activity', 'sterol 5-alpha reductase activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa05215", "R-HSA-1430728", "R-HSA-193048", "R-HSA-196071", "R-HSA-556833", "R-HSA-8957322" ], "essential_gene": null, "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000277893", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.477987" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "583" }, { "type": "SmallVariant", "id": "2172" }, { "type": "SmallVariant", "id": "2179" }, { "type": "SmallVariant", "id": "3182" }, { "type": "SmallVariant", "id": "3206" }, { "type": "SmallVariant", "id": "3221" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRD5A2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRD5A2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "201" }, { "type": "GeneCombination", "id": "268" }, { "type": "GeneCombination", "id": "739" }, { "type": "GeneCombination", "id": "1077" }, { "type": "GeneCombination", "id": "1063" }, { "type": "GeneCombination", "id": "1071" }, { "type": "GeneCombination", "id": "1084" }, { "type": "GeneCombination", "id": "1090" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRD5A2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRD5A2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SRD5A2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }