Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/762/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ERBB4", "attributes": { "go_molecular_function": [ "['epidermal growth factor receptor binding', 'protein tyrosine kinase activity', 'protein homodimerization activity', 'transmembrane receptor protein tyrosine kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'transcription cis-regulatory region binding', 'protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04012", "kegg_path:hsa04020", "kegg_path:hsa04151", "kegg_path:hsa05014", "kegg_path:hsa05205" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15303", "ensembl_id": "None", "entrez_id": "ENSG00000178568", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.341456" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1896" }, { "type": "SmallVariant", "id": "2072" }, { "type": "SmallVariant", "id": "2262" }, { "type": "SmallVariant", "id": "2263" }, { "type": "SmallVariant", "id": "3353" }, { "type": "SmallVariant", "id": "3447" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ERBB4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ERBB4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "634" }, { "type": "GeneCombination", "id": "648" }, { "type": "GeneCombination", "id": "668" }, { "type": "GeneCombination", "id": "670" }, { "type": "GeneCombination", "id": "716" }, { "type": "GeneCombination", "id": "762" }, { "type": "GeneCombination", "id": "1128" }, { "type": "GeneCombination", "id": "1158" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ERBB4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ERBB4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ERBB4/?format=api" } }, { "type": "Gene", "id": "PKP1", "attributes": { "go_molecular_function": [ "protein binding", "intermediate filament binding", "structural constituent of skin epidermis", "lamin binding", "cadherin binding" ], "pathway_id": [ "R-HSA-75153", "R-HSA-6805567", "R-HSA-6798695", "R-HSA-6809371", "R-HSA-1266738", "R-HSA-168256", "R-HSA-5357801", "R-HSA-109581", "R-HSA-111465", "R-HSA-351906", "R-HSA-168249" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13835", "ensembl_id": "ENSG00000081277", "entrez_id": "5317", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:58.360774" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2264" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PKP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PKP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "762" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PKP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PKP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PKP1/?format=api" } }, { "type": "Gene", "id": "RYR3", "attributes": { "go_molecular_function": [ "['calcium-induced calcium release activity', 'calcium ion binding', 'ryanodine-sensitive calcium-release channel activity', 'calcium-release channel activity', 'calmodulin binding']" ], "pathway_id": [ "kegg_path:hsa04020", "kegg_path:hsa04371", "kegg_path:hsa04713", "kegg_path:hsa04921", "kegg_path:hsa04970", "kegg_path:hsa05010", "kegg_path:hsa05012", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-2672351", "R-HSA-382551", "R-HSA-397014", "R-HSA-5576891", "R-HSA-5578775", "R-HSA-983712" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "A0A0X1KG73", "ensembl_id": "None", "entrez_id": "ENSG00000198838", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.558256" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1733" }, { "type": "SmallVariant", "id": "2257" }, { "type": "SmallVariant", "id": "2265" }, { "type": "SmallVariant", "id": "3071" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RYR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RYR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "571" }, { "type": "GeneCombination", "id": "761" }, { "type": "GeneCombination", "id": "762" }, { "type": "GeneCombination", "id": "1030" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RYR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RYR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RYR3/?format=api" } }, { "type": "Gene", "id": "SAMD11", "attributes": { "go_molecular_function": [ "chromatin binding", "histone binding", "protein binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96NU1", "ensembl_id": "ENSG00000187634", "entrez_id": "148398", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:59.520075" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2266" }, { "type": "SmallVariant", "id": "2340" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SAMD11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SAMD11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "762" }, { "type": "GeneCombination", "id": "765" }, { "type": "GeneCombination", "id": "774" }, { "type": "GeneCombination", "id": "778" }, { "type": "GeneCombination", "id": "787" }, { "type": "GeneCombination", "id": "790" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SAMD11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SAMD11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SAMD11/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }