Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/527/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CELSR1", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity', 'calcium ion binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NYQ6", "ensembl_id": "None", "entrez_id": "ENSG00000075275", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.610366" }, "relationships": { "variant_set": { "meta": { "count": 18 }, "data": [ { "type": "SmallVariant", "id": "3114" }, { "type": "SmallVariant", "id": "1073" }, { "type": "SmallVariant", "id": "1075" }, { "type": "SmallVariant", "id": "1077" }, { "type": "SmallVariant", "id": "1081" }, { "type": "SmallVariant", "id": "1481" }, { "type": "SmallVariant", "id": "1486" }, { "type": "SmallVariant", "id": "1517" }, { "type": "SmallVariant", "id": "1552" }, { "type": "SmallVariant", "id": "1630" }, { "type": "SmallVariant", "id": "1678" }, { "type": "SmallVariant", "id": "3103" }, { "type": "SmallVariant", "id": "3105" }, { "type": "SmallVariant", "id": "3107" }, { "type": "SmallVariant", "id": "3109" }, { "type": "SmallVariant", "id": "3111" }, { "type": "SmallVariant", "id": "3112" }, { "type": "SmallVariant", "id": "3116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "351" }, { "type": "GeneCombination", "id": "352" }, { "type": "GeneCombination", "id": "473" }, { "type": "GeneCombination", "id": "475" }, { "type": "GeneCombination", "id": "487" }, { "type": "GeneCombination", "id": "499" }, { "type": "GeneCombination", "id": "527" }, { "type": "GeneCombination", "id": "538" }, { "type": "GeneCombination", "id": "547" }, { "type": "GeneCombination", "id": "1040" }, { "type": "GeneCombination", "id": "1041" }, { "type": "GeneCombination", "id": "1043" }, { "type": "GeneCombination", "id": "1042" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR1/?format=api" } }, { "type": "Gene", "id": "MTHFD1L", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'methylenetetrahydrofolate dehydrogenase (NADP+) activity', 'ATP binding', 'formate-tetrahydrofolate ligase activity']" ], "pathway_id": [ "kegg_path:hsa00670", "kegg_path:hsa01100", "kegg_path:hsa01240", "R-HSA-1430728", "R-HSA-196757", "R-HSA-196849", "R-HSA-196854" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q6UB35", "ensembl_id": "None", "entrez_id": "ENSG00000120254", "chromosome_number": "6", "lastmodified": "2021-10-18T11:00:44.685735" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1631" }, { "type": "SmallVariant", "id": "3101" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFD1L/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFD1L/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "527" }, { "type": "GeneCombination", "id": "1039" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFD1L/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFD1L/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFD1L/?format=api" } }, { "type": "Gene", "id": "RNMT", "attributes": { "go_molecular_function": [ "mRNA (guanine-N7-)-methyltransferase activity", "transferase activity", "protein binding", "RNA binding", "methyltransferase activity" ], "pathway_id": [ "kegg_path:hsa03015", "R-HSA-167172", "R-HSA-77075", "R-HSA-1643685", "R-HSA-167160", "R-HSA-8953854", "R-HSA-162906", "R-HSA-74160", "R-HSA-162587", "R-HSA-162599", "R-HSA-5663205", "R-HSA-72086", "R-HSA-73857" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O43148", "ensembl_id": "ENSG00000101654", "entrez_id": "8731", "chromosome_number": "18", "lastmodified": "2021-10-18T11:00:44.462692" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1629" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RNMT/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RNMT/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "527" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RNMT/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RNMT/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RNMT/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }