Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1203/genes/?format=api
{ "data": [ { "type": "Gene", "id": "COL6A6", "attributes": { "go_molecular_function": [ "['extracellular matrix structural constituent conferring tensile strength']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04974", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1474290", "R-HSA-162582", "R-HSA-1650814", "R-HSA-186797", "R-HSA-2022090", "R-HSA-216083", "R-HSA-3000178", "R-HSA-375165", "R-HSA-419037", "R-HSA-422475", "R-HSA-8948216", "R-HSA-9006934", "R-HSA-9675108" ], "essential_gene": null, "status": "CU", "uniprot_acc": "A6NMZ7", "ensembl_id": "None", "entrez_id": "ENSG00000206384", "chromosome_number": "3", "lastmodified": "2024-02-29T15:02:20.617931" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3574" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL6A6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL6A6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1203" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL6A6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL6A6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL6A6/?format=api" } }, { "type": "Gene", "id": "LOXHD1", "attributes": { "go_molecular_function": [], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8IVV2", "ensembl_id": "None", "entrez_id": "ENSG00000167210", "chromosome_number": "18", "lastmodified": "2024-02-29T15:02:20.475327" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3516" }, { "type": "SmallVariant", "id": "3528" }, { "type": "SmallVariant", "id": "3575" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LOXHD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LOXHD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1185" }, { "type": "GeneCombination", "id": "1190" }, { "type": "GeneCombination", "id": "1203" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LOXHD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LOXHD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LOXHD1/?format=api" } }, { "type": "Gene", "id": "LRP1B", "attributes": { "go_molecular_function": [ "['calcium ion binding', 'protein binding', 'low-density lipoprotein particle receptor activity']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NZR2", "ensembl_id": "None", "entrez_id": "ENSG00000168702", "chromosome_number": "2", "lastmodified": "2023-05-16T12:02:32.849547" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "2786" }, { "type": "SmallVariant", "id": "2787" }, { "type": "SmallVariant", "id": "3572" }, { "type": "SmallVariant", "id": "3576" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP1B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP1B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "932" }, { "type": "GeneCombination", "id": "1203" }, { "type": "GeneCombination", "id": "1204" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP1B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP1B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LRP1B/?format=api" } }, { "type": "Gene", "id": "PIK3CG", "attributes": { "go_molecular_function": [ "['phosphatidylinositol kinase activity', 'phosphatidylinositol 3-kinase activity', 'protein serine kinase activity', '1-phosphatidylinositol-3-kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'phosphatidylinositol-3,4-bisphosphate 5-kinase activity', 'protein binding', 'protein kinase activity', '1-phosphatidylinositol-4-phosphate 3-kinase activity', 'ephrin receptor binding', 'protein serine/threonine kinase activity', 'phosphatidylinositol-4,5-bisphosphate 3-kinase activity', 'kinase activity', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa00562", "kegg_path:hsa01100", "kegg_path:hsa04022", "kegg_path:hsa04062", "kegg_path:hsa04072", "kegg_path:hsa04151", "kegg_path:hsa04261", "kegg_path:hsa04371", "kegg_path:hsa04611", "kegg_path:hsa04725", "kegg_path:hsa04921", "kegg_path:hsa05132", "kegg_path:hsa05145", "kegg_path:hsa05167", "kegg_path:hsa00562", "kegg_path:hsa01100", "kegg_path:hsa04022", "kegg_path:hsa04062", "kegg_path:hsa04072", "kegg_path:hsa04151", "kegg_path:hsa04261", "kegg_path:hsa04371", "kegg_path:hsa04611", "kegg_path:hsa04725", "kegg_path:hsa04921", "kegg_path:hsa05132", "kegg_path:hsa05145", "kegg_path:hsa05167", "R-HSA-109582", "R-HSA-114604", "R-HSA-1430728", "R-HSA-1483255", "R-HSA-1483257", "R-HSA-162582", "R-HSA-1660499", "R-HSA-372790", "R-HSA-388396", "R-HSA-392451", "R-HSA-397795", "R-HSA-556833", "R-HSA-76002", "R-HSA-9006335", "R-HSA-9027276" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P48736", "ensembl_id": "None", "entrez_id": "ENSG00000105851", "chromosome_number": "7", "lastmodified": "2024-02-29T15:02:20.614071" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3573" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PIK3CG/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PIK3CG/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1203" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PIK3CG/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PIK3CG/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PIK3CG/?format=api" } }, { "type": "Gene", "id": "SLC4A11", "attributes": { "go_molecular_function": [ "['active borate transmembrane transporter activity', 'proton transmembrane transporter activity', 'bicarbonate transmembrane transporter activity', 'anion:anion antiporter activity', 'transmembrane transporter activity', 'sodium channel activity', 'protein dimerization activity', 'water transmembrane transporter activity', 'symporter activity', 'inorganic anion exchanger activity', 'proton channel activity']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8NBS3", "ensembl_id": "None", "entrez_id": "ENSG00000088836", "chromosome_number": "20", "lastmodified": "2023-05-16T12:02:32.751178" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2756" }, { "type": "SmallVariant", "id": "3571" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC4A11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC4A11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "920" }, { "type": "GeneCombination", "id": "1203" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC4A11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC4A11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SLC4A11/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }