Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/860/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ABCG5", "attributes": { "go_molecular_function": [ "ATPase-coupled transmembrane transporter activity", "protein binding", "ATP hydrolysis activity", "metal ion binding", "ATP binding", "protein heterodimerization activity", "ABC-type transporter activity", "cholesterol transfer activity" ], "pathway_id": [ "R-HSA-382556", "R-HSA-162582", "kegg_path:hsa04975", "R-HSA-5679096", "kegg_path:hsa02010", "kegg_path:hsa04976", "R-HSA-1369062", "R-HSA-1643685", "kegg_path:hsa04979", "R-HSA-5619115", "R-HSA-9024446", "R-HSA-9006931", "R-HSA-9029569", "R-HSA-5619084", "R-HSA-5679090", "R-HSA-382551" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9H222", "ensembl_id": "ENSG00000138075", "entrez_id": "64240", "chromosome_number": "2", "lastmodified": "2022-08-04T14:14:58.018547" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2583" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ABCG5/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ABCG5/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "860" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ABCG5/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ABCG5/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ABCG5/?format=api" } }, { "type": "Gene", "id": "CD36", "attributes": { "go_molecular_function": [ "amyloid-beta binding", "scavenger receptor activity", "protein binding", "long-chain fatty acid transporter activity", "short-chain fatty acid transmembrane transporter activity", "thrombospondin receptor activity", "lipid binding", "low-density lipoprotein particle binding", "lipoprotein particle binding", "oxidised low-density lipoprotein particle receptor activity", "oleate transmembrane transporter activity", "transforming growth factor beta binding", "low-density lipoprotein particle receptor activity", "high-density lipoprotein particle binding", "lipoteichoic acid immune receptor activity", "protein-containing complex binding", "Toll-like receptor binding" ], "pathway_id": [ "kegg_path:hsa03320", "R-HSA-1643685", "R-HSA-1280218", "R-HSA-168249", "R-HSA-3000471", "kegg_path:hsa04145", "kegg_path:hsa04640", "kegg_path:hsa04931", "R-HSA-422356", "R-HSA-168179", "R-HSA-1236973", "R-HSA-1280215", "R-HSA-76002", "R-HSA-2173782", "R-HSA-5653656", "R-HSA-109582", "R-HSA-1236975", "kegg_path:hsa04152", "kegg_path:hsa05144", "R-HSA-400451", "kegg_path:hsa04512", "kegg_path:hsa04975", "R-HSA-1266738", "R-HSA-400206", "kegg_path:hsa04920", "R-HSA-5603041", "R-HSA-5602498", "kegg_path:hsa04979", "R-HSA-6798695", "kegg_path:hsa05144", "R-HSA-556833", "kegg_path:hsa04152", "R-HSA-168898", "R-HSA-5260271", "R-HSA-5686938", "R-HSA-381340", "R-HSA-163685", "R-HSA-168256", "R-HSA-1989781", "kegg_path:hsa04931", "kegg_path:hsa04640", "R-HSA-1236974", "R-HSA-1430728", "kegg_path:hsa04145", "R-HSA-114608", "kegg_path:hsa03320", "R-HSA-166016", "R-HSA-449147", "kegg_path:hsa04979", "R-HSA-434313", "R-HSA-6785807", "R-HSA-168188", "kegg_path:hsa04920", "R-HSA-181438", "R-HSA-76005", "kegg_path:hsa04975", "R-HSA-5602358", "R-HSA-983169", "kegg_path:hsa04512", "R-HSA-166058" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P16671", "ensembl_id": "ENSG00000135218", "entrez_id": "948", "chromosome_number": "7", "lastmodified": "2022-08-04T14:14:59.641842" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2584" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CD36/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CD36/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "860" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CD36/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CD36/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CD36/?format=api" } }, { "type": "Gene", "id": "PCSK9", "attributes": { "go_molecular_function": [ "very-low-density lipoprotein particle binding", "apolipoprotein receptor binding", "protein binding", "low-density lipoprotein particle receptor binding", "apolipoprotein binding", "serine-type endopeptidase activity", "low-density lipoprotein particle binding", "very-low-density lipoprotein particle receptor binding", "RNA binding", "protein self-association", "signaling receptor inhibitor activity", "sodium channel inhibitor activity" ], "pathway_id": [ "R-HSA-392499", "R-HSA-381426", "R-HSA-597592", "R-HSA-8964043", "R-HSA-8964038", "R-HSA-8866427", "R-HSA-174824", "R-HSA-382551", "R-HSA-8957275", "kegg_path:hsa04979" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8NBP7", "ensembl_id": "ENSG00000169174", "entrez_id": "255738", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.626222" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "992" }, { "type": "SmallVariant", "id": "1064" }, { "type": "SmallVariant", "id": "1801" }, { "type": "SmallVariant", "id": "1802" }, { "type": "SmallVariant", "id": "2582" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PCSK9/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PCSK9/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "317" }, { "type": "GeneCombination", "id": "347" }, { "type": "GeneCombination", "id": "860" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PCSK9/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PCSK9/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PCSK9/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }