Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/723/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FIG4", "attributes": { "go_molecular_function": [ "['phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity', 'protein serine/threonine phosphatase activity', 'phosphatidylinositol-4-phosphate phosphatase activity', 'phosphatidylinositol-3-phosphatase activity', 'protein binding', 'phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity', 'phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity']" ], "pathway_id": [ "kegg_path:hsa00562", "kegg_path:hsa01100", "kegg_path:hsa05014", "kegg_path:hsa05022", "R-HSA-1430728", "R-HSA-1483255", "R-HSA-1483257", "R-HSA-1660514", "R-HSA-1660516", "R-HSA-1660517", "R-HSA-556833" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q92562", "ensembl_id": "None", "entrez_id": "ENSG00000112367", "chromosome_number": "6", "lastmodified": "2021-10-18T11:00:44.947126" }, "relationships": { "variant_set": { "meta": { "count": 11 }, "data": [ { "type": "SmallVariant", "id": "549" }, { "type": "SmallVariant", "id": "941" }, { "type": "SmallVariant", "id": "1426" }, { "type": "SmallVariant", "id": "1433" }, { "type": "SmallVariant", "id": "1438" }, { "type": "SmallVariant", "id": "2053" }, { "type": "SmallVariant", "id": "2055" }, { "type": "SmallVariant", "id": "2089" }, { "type": "SmallVariant", "id": "2197" }, { "type": "SmallVariant", "id": "3431" }, { "type": "SmallVariant", "id": "3439" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FIG4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FIG4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "187" }, { "type": "GeneCombination", "id": "300" }, { "type": "GeneCombination", "id": "449" }, { "type": "GeneCombination", "id": "453" }, { "type": "GeneCombination", "id": "456" }, { "type": "GeneCombination", "id": "708" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "1154" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FIG4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FIG4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FIG4/?format=api" } }, { "type": "Gene", "id": "GRN", "attributes": { "go_molecular_function": [ "['growth factor activity', 'protein binding', 'RNA binding', 'cytokine activity', 'chaperone binding']" ], "pathway_id": [ "R-HSA-168249", "R-HSA-168256", "R-HSA-6798695" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P28799", "ensembl_id": "None", "entrez_id": "ENSG00000030582", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.551264" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1440" }, { "type": "SmallVariant", "id": "1815" }, { "type": "SmallVariant", "id": "2045" }, { "type": "SmallVariant", "id": "2087" }, { "type": "SmallVariant", "id": "3422" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "457" }, { "type": "GeneCombination", "id": "601" }, { "type": "GeneCombination", "id": "704" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "1148" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GRN/?format=api" } }, { "type": "Gene", "id": "HFE", "attributes": { "go_molecular_function": [ "protein binding", "transferrin receptor binding", "signaling receptor binding", "co-receptor binding", "beta-2-microglobulin binding" ], "pathway_id": [ "R-HSA-917937", "R-HSA-382551", "R-HSA-917977" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q30201", "ensembl_id": "ENSG00000010704", "entrez_id": "3077", "chromosome_number": "6", "lastmodified": "2021-10-18T11:00:44.614318" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "337" }, { "type": "SmallVariant", "id": "363" }, { "type": "SmallVariant", "id": "2088" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HFE/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HFE/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "118" }, { "type": "GeneCombination", "id": "126" }, { "type": "GeneCombination", "id": "723" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HFE/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HFE/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HFE/?format=api" } }, { "type": "Gene", "id": "SOD1", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'small GTPase binding', 'superoxide dismutase activity', 'protein binding', 'protein phosphatase 2B binding', 'copper ion binding', 'chaperone binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04146", "kegg_path:hsa04213", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-109582", "R-HSA-114608", "R-HSA-1280215", "R-HSA-168256", "R-HSA-2262752", "R-HSA-3299685", "R-HSA-447115", "R-HSA-449147", "R-HSA-76002", "R-HSA-76005", "R-HSA-8950505", "R-HSA-8953897", "R-HSA-9020591" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00441", "ensembl_id": "None", "entrez_id": "ENSG00000142168", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.427208" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "1693" }, { "type": "SmallVariant", "id": "525" }, { "type": "SmallVariant", "id": "527" }, { "type": "SmallVariant", "id": "541" }, { "type": "SmallVariant", "id": "638" }, { "type": "SmallVariant", "id": "693" }, { "type": "SmallVariant", "id": "936" }, { "type": "SmallVariant", "id": "937" }, { "type": "SmallVariant", "id": "1379" }, { "type": "SmallVariant", "id": "1428" }, { "type": "SmallVariant", "id": "1709" }, { "type": "SmallVariant", "id": "2035" }, { "type": "SmallVariant", "id": "2039" }, { "type": "SmallVariant", "id": "2050" }, { "type": "SmallVariant", "id": "2189" }, { "type": "SmallVariant", "id": "3418" }, { "type": "SmallVariant", "id": "3426" }, { "type": "SmallVariant", "id": "3432" }, { "type": "SmallVariant", "id": "3446" }, { "type": "SmallVariant", "id": "3600" }, { "type": "SmallVariant", "id": "3603" }, { "type": "SmallVariant", "id": "3605" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 36 }, "data": [ { "type": "GeneCombination", "id": "173" }, { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "298" }, { "type": "GeneCombination", "id": "434" }, { "type": "GeneCombination", "id": "451" }, { "type": "GeneCombination", "id": "552" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "561" }, { "type": "GeneCombination", "id": "562" }, { "type": "GeneCombination", "id": "699" }, { "type": "GeneCombination", "id": "700" }, { "type": "GeneCombination", "id": "701" }, { "type": "GeneCombination", "id": "702" }, { "type": "GeneCombination", "id": "706" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1154" }, { "type": "GeneCombination", "id": "1158" }, { "type": "GeneCombination", "id": "1212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }