Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/127/genes/?format=api
{ "data": [ { "type": "Gene", "id": "MUTYH", "attributes": { "go_molecular_function": [ "MutLbeta complex binding", "MutSalpha complex binding", "protein binding", "4 iron, 4 sulfur cluster binding", "oxidized purine DNA binding", "adenine/guanine mispair binding", "MutSbeta complex binding", "purine-specific mismatch base pair DNA N-glycosylase activity", "hydrolase activity, acting on glycosyl bonds", "catalytic activity", "hydrolase activity", "8-oxo-7,8-dihydroguanine DNA N-glycosylase activity", "DNA binding", "MutLalpha complex binding" ], "pathway_id": [ "kegg_path:hsa03410", "kegg_path:hsa03410" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9UIF7", "ensembl_id": "ENSG00000132781", "entrez_id": "4595", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.412032" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "47" }, { "type": "SmallVariant", "id": "367" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MUTYH/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MUTYH/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "20" }, { "type": "GeneCombination", "id": "127" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MUTYH/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MUTYH/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MUTYH/?format=api" } }, { "type": "Gene", "id": "OGG1", "attributes": { "go_molecular_function": [ "damaged DNA binding", "endonuclease activity", "oxidized purine nucleobase lesion DNA N-glycosylase activity", "class I DNA-(apurinic or apyrimidinic site) endonuclease activity" ], "pathway_id": [ "R-HSA-9656256", "kegg_path:hsa03410", "R-HSA-110329", "R-HSA-5649702", "kegg_path:hsa03410", "R-HSA-110331", "R-HSA-9656249", "R-HSA-9656255", "R-HSA-9675135", "R-HSA-110330", "R-HSA-73884", "R-HSA-73927", "R-HSA-73933", "R-HSA-1643685", "R-HSA-73894", "R-HSA-110328", "R-HSA-9605308", "R-HSA-110357", "R-HSA-73928", "R-HSA-73929" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O15527", "ensembl_id": "ENSG00000114026", "entrez_id": "4968", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.470185" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "366" }, { "type": "SmallVariant", "id": "551" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OGG1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OGG1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "127" }, { "type": "GeneCombination", "id": "188" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OGG1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OGG1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/OGG1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }