Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/912/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CYP7A1", "attributes": { "go_molecular_function": [ "['cholesterol 7-alpha-monooxygenase activity', 'iron ion binding', 'heme binding', 'steroid hydroxylase activity', '24-hydroxycholesterol 7alpha-hydroxylase activity']" ], "pathway_id": [ "kegg_path:hsa00120", "kegg_path:hsa00140", "kegg_path:hsa01100", "kegg_path:hsa03320", "kegg_path:hsa04976", "kegg_path:hsa04979", "R-HSA-1430728", "R-HSA-192105", "R-HSA-193368", "R-HSA-193807", "R-HSA-194068", "R-HSA-1989781", "R-HSA-211859", "R-HSA-211897", "R-HSA-211945", "R-HSA-211976", "R-HSA-400206", "R-HSA-556833", "R-HSA-8957322" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P22680", "ensembl_id": "None", "entrez_id": "ENSG00000167910", "chromosome_number": "8", "lastmodified": "2023-05-16T12:02:32.668722" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2735" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP7A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP7A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "911" }, { "type": "GeneCombination", "id": "912" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP7A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP7A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CYP7A1/?format=api" } }, { "type": "Gene", "id": "LRP6", "attributes": { "go_molecular_function": [ "['kinase inhibitor activity', 'coreceptor activity involved in Wnt signaling pathway', 'Wnt-protein binding', 'protein homodimerization activity', 'frizzled binding', 'Wnt-activated receptor activity', 'coreceptor activity involved in canonical Wnt signaling pathway', 'protein binding', 'toxin transmembrane transporter activity', 'low-density lipoprotein particle receptor activity', 'identical protein binding', 'signaling receptor binding']" ], "pathway_id": [ "kegg_path:hsa04150", "kegg_path:hsa04310", "kegg_path:hsa04928", "kegg_path:hsa05010", "kegg_path:hsa05022", "kegg_path:hsa05200", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "R-HSA-162582", "R-HSA-1643685", "R-HSA-195721", "R-HSA-201681", "R-HSA-3772470", "R-HSA-4641262", "R-HSA-4641263", "R-HSA-4791275", "R-HSA-5340588", "R-HSA-5663202" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O75581", "ensembl_id": "None", "entrez_id": "ENSG00000070018", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:59.019813" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "2026" }, { "type": "SmallVariant", "id": "2028" }, { "type": "SmallVariant", "id": "2029" }, { "type": "SmallVariant", "id": "2030" }, { "type": "SmallVariant", "id": "2031" }, { "type": "SmallVariant", "id": "2032" }, { "type": "SmallVariant", "id": "2736" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "698" }, { "type": "GeneCombination", "id": "911" }, { "type": "GeneCombination", "id": "912" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LRP6/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }