Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/411/genes/?format=api
{ "data": [ { "type": "Gene", "id": "EVC", "attributes": { "go_molecular_function": [], "pathway_id": [ "kegg_path:hsa04340", "R-HSA-162582", "R-HSA-5358351", "R-HSA-5632684", "R-HSA-5635838" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000072840", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.537890" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "764" }, { "type": "SmallVariant", "id": "765" }, { "type": "SmallVariant", "id": "1270" }, { "type": "SmallVariant", "id": "1277" }, { "type": "SmallVariant", "id": "1311" }, { "type": "SmallVariant", "id": "2635" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EVC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EVC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "878" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EVC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EVC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EVC/?format=api" } }, { "type": "Gene", "id": "MAML3", "attributes": { "go_molecular_function": [ "transcription coactivator activity" ], "pathway_id": [ "R-HSA-157118", "R-HSA-186712", "R-HSA-73857", "R-HSA-2644603", "R-HSA-2894858", "R-HSA-1912422", "R-HSA-2894862", "R-HSA-9012852", "R-HSA-2644602", "R-HSA-1643685", "R-HSA-8941856", "R-HSA-210744", "R-HSA-2644606", "R-HSA-1266738", "kegg_path:hsa05165", "kegg_path:hsa04658", "R-HSA-2197563", "R-HSA-1980145", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-212436", "R-HSA-9013694", "R-HSA-9013508", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-1912408", "R-HSA-162582", "R-HSA-1980143", "kegg_path:hsa04330", "R-HSA-8878159" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96JK9", "ensembl_id": "ENSG00000196782", "entrez_id": "55534", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.620397" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "730" }, { "type": "SmallVariant", "id": "755" }, { "type": "SmallVariant", "id": "1305" }, { "type": "SmallVariant", "id": "1312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAML3/?format=api" } }, { "type": "Gene", "id": "MAMLD1", "attributes": { "go_molecular_function": [ "['molecular_function']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13495", "ensembl_id": "None", "entrez_id": "ENSG00000013619", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.997839" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "581" }, { "type": "SmallVariant", "id": "717" }, { "type": "SmallVariant", "id": "722" }, { "type": "SmallVariant", "id": "729" }, { "type": "SmallVariant", "id": "733" }, { "type": "SmallVariant", "id": "736" }, { "type": "SmallVariant", "id": "742" }, { "type": "SmallVariant", "id": "745" }, { "type": "SmallVariant", "id": "752" }, { "type": "SmallVariant", "id": "757" }, { "type": "SmallVariant", "id": "1268" }, { "type": "SmallVariant", "id": "1278" }, { "type": "SmallVariant", "id": "1280" }, { "type": "SmallVariant", "id": "1283" }, { "type": "SmallVariant", "id": "1294" }, { "type": "SmallVariant", "id": "1310" }, { "type": "SmallVariant", "id": "1316" }, { "type": "SmallVariant", "id": "3192" }, { "type": "SmallVariant", "id": "3200" }, { "type": "SmallVariant", "id": "3252" }, { "type": "SmallVariant", "id": "3259" }, { "type": "SmallVariant", "id": "3325" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "406" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1095" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/?format=api" } }, { "type": "Gene", "id": "NOTCH2", "attributes": { "go_molecular_function": [ "calcium ion binding", "protein binding", "enzyme binding", "NF-kappaB binding", "signaling receptor activity" ], "pathway_id": [ "R-HSA-1912399", "R-HSA-1912408", "R-HSA-162582", "kegg_path:hsa04330", "kegg_path:hsa04919", "kegg_path:hsa05200", "kegg_path:hsa05206", "R-HSA-350054", "R-HSA-74160", "R-HSA-1980145", "kegg_path:hsa05224", "kegg_path:hsa01522", "R-HSA-9013695", "R-HSA-212436", "R-HSA-9013694", "kegg_path:hsa05165", "R-HSA-3906995", "kegg_path:hsa04658", "R-HSA-2197563", "R-HSA-5668914", "kegg_path:hsa04919", "kegg_path:hsa04330", "R-HSA-3781865", "kegg_path:hsa05206", "R-HSA-1643685", "kegg_path:hsa05200", "R-HSA-2979096", "kegg_path:hsa05224", "R-HSA-1912422", "kegg_path:hsa01522", "kegg_path:hsa05165", "R-HSA-157118", "R-HSA-1912420", "R-HSA-5083630", "R-HSA-73857", "kegg_path:hsa04658" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q04721", "ensembl_id": "ENSG00000134250", "entrez_id": "4853", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.464507" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "501" }, { "type": "SmallVariant", "id": "724" }, { "type": "SmallVariant", "id": "762" }, { "type": "SmallVariant", "id": "1293" }, { "type": "SmallVariant", "id": "1313" }, { "type": "SmallVariant", "id": "2305" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "167" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "774" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH2/?format=api" } }, { "type": "Gene", "id": "PPARGC1B", "attributes": { "go_molecular_function": [ "AF-2 domain binding", "transcription coregulator activity", "RNA binding", "estrogen receptor binding", "nucleic acid binding", "nuclear receptor coactivator activity" ], "pathway_id": [ "R-HSA-556833", "R-HSA-212436", "R-HSA-1989781", "R-HSA-400206", "R-HSA-1430728", "R-HSA-73857", "kegg_path:hsa04931", "R-HSA-8939902", "R-HSA-2151201", "R-HSA-1592230", "R-HSA-74160", "R-HSA-1852241", "R-HSA-8878166" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q86YN6", "ensembl_id": "ENSG00000155846", "entrez_id": "133522", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:45.008392" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1314" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PPARGC1B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PPARGC1B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "411" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PPARGC1B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PPARGC1B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PPARGC1B/?format=api" } }, { "type": "Gene", "id": "WDR11", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9BZH6", "ensembl_id": "None", "entrez_id": "ENSG00000120008", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.980173" }, "relationships": { "variant_set": { "meta": { "count": 16 }, "data": [ { "type": "SmallVariant", "id": "27" }, { "type": "SmallVariant", "id": "782" }, { "type": "SmallVariant", "id": "1309" }, { "type": "SmallVariant", "id": "1315" }, { "type": "SmallVariant", "id": "1869" }, { "type": "SmallVariant", "id": "1870" }, { "type": "SmallVariant", "id": "2407" }, { "type": "SmallVariant", "id": "2501" }, { "type": "SmallVariant", "id": "2503" }, { "type": "SmallVariant", "id": "2511" }, { "type": "SmallVariant", "id": "2665" }, { "type": "SmallVariant", "id": "2680" }, { "type": "SmallVariant", "id": "2729" }, { "type": "SmallVariant", "id": "2855" }, { "type": "SmallVariant", "id": "2936" }, { "type": "SmallVariant", "id": "3366" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WDR11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WDR11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 12 }, "data": [ { "type": "GeneCombination", "id": "10" }, { "type": "GeneCombination", "id": "245" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "621" }, { "type": "GeneCombination", "id": "851" }, { "type": "GeneCombination", "id": "820" }, { "type": "GeneCombination", "id": "886" }, { "type": "GeneCombination", "id": "892" }, { "type": "GeneCombination", "id": "908" }, { "type": "GeneCombination", "id": "976" }, { "type": "GeneCombination", "id": "848" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WDR11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WDR11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/WDR11/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }