Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/965/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GNRHR", "attributes": { "go_molecular_function": [ "['peptide binding', 'G protein-coupled receptor activity', 'gonadotropin-releasing hormone receptor activity']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04912", "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375281", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P30968", "ensembl_id": "None", "entrez_id": "ENSG00000109163", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.928979" }, "relationships": { "variant_set": { "meta": { "count": 21 }, "data": [ { "type": "SmallVariant", "id": "330" }, { "type": "SmallVariant", "id": "380" }, { "type": "SmallVariant", "id": "381" }, { "type": "SmallVariant", "id": "387" }, { "type": "SmallVariant", "id": "391" }, { "type": "SmallVariant", "id": "401" }, { "type": "SmallVariant", "id": "915" }, { "type": "SmallVariant", "id": "1716" }, { "type": "SmallVariant", "id": "2504" }, { "type": "SmallVariant", "id": "2505" }, { "type": "SmallVariant", "id": "2507" }, { "type": "SmallVariant", "id": "2508" }, { "type": "SmallVariant", "id": "2685" }, { "type": "SmallVariant", "id": "2690" }, { "type": "SmallVariant", "id": "2905" }, { "type": "SmallVariant", "id": "2909" }, { "type": "SmallVariant", "id": "3364" }, { "type": "SmallVariant", "id": "3365" }, { "type": "SmallVariant", "id": "3369" }, { "type": "SmallVariant", "id": "3370" }, { "type": "SmallVariant", "id": "3383" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GNRHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GNRHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "133" }, { "type": "GeneCombination", "id": "116" }, { "type": "GeneCombination", "id": "287" }, { "type": "GeneCombination", "id": "563" }, { "type": "GeneCombination", "id": "619" }, { "type": "GeneCombination", "id": "633" }, { "type": "GeneCombination", "id": "659" }, { "type": "GeneCombination", "id": "665" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "849" }, { "type": "GeneCombination", "id": "872" }, { "type": "GeneCombination", "id": "130" }, { "type": "GeneCombination", "id": "894" }, { "type": "GeneCombination", "id": "895" }, { "type": "GeneCombination", "id": "905" }, { "type": "GeneCombination", "id": "909" }, { "type": "GeneCombination", "id": "955" }, { "type": "GeneCombination", "id": "957" }, { "type": "GeneCombination", "id": "963" }, { "type": "GeneCombination", "id": "965" }, { "type": "GeneCombination", "id": "980" }, { "type": "GeneCombination", "id": "1062" }, { "type": "GeneCombination", "id": "850" }, { "type": "GeneCombination", "id": "848" }, { "type": "GeneCombination", "id": "1130" }, { "type": "GeneCombination", "id": "1134" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GNRHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GNRHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GNRHR/?format=api" } }, { "type": "Gene", "id": "IGSF10", "attributes": { "go_molecular_function": [], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q6WRI0", "ensembl_id": "None", "entrez_id": "ENSG00000152580", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.985482" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1161" }, { "type": "SmallVariant", "id": "1413" }, { "type": "SmallVariant", "id": "2611" }, { "type": "SmallVariant", "id": "2911" }, { "type": "SmallVariant", "id": "2930" }, { "type": "SmallVariant", "id": "2960" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IGSF10/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IGSF10/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "372" }, { "type": "GeneCombination", "id": "443" }, { "type": "GeneCombination", "id": "866" }, { "type": "GeneCombination", "id": "965" }, { "type": "GeneCombination", "id": "973" }, { "type": "GeneCombination", "id": "985" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IGSF10/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IGSF10/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IGSF10/?format=api" } }, { "type": "Gene", "id": "NDNF", "attributes": { "go_molecular_function": [ "['heparin binding', 'glycosaminoglycan binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8TB73", "ensembl_id": "None", "entrez_id": "ENSG00000173376", "chromosome_number": "4", "lastmodified": "2023-05-16T12:02:33.134683" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2910" }, { "type": "SmallVariant", "id": "2921" }, { "type": "SmallVariant", "id": "2982" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NDNF/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NDNF/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "965" }, { "type": "GeneCombination", "id": "970" }, { "type": "GeneCombination", "id": "995" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NDNF/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NDNF/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NDNF/?format=api" } }, { "type": "Gene", "id": "SOX10", "attributes": { "go_molecular_function": [ "['DNA-binding transcription activator activity', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'transcription cis-regulatory region binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'DNA binding', 'sequence-specific double-stranded DNA binding', 'protein binding', 'promoter-specific chromatin binding', 'DNA-binding transcription factor binding', 'identical protein binding', 'DNA-binding transcription factor activity']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-9619665", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P56693", "ensembl_id": "None", "entrez_id": "ENSG00000100146", "chromosome_number": "22", "lastmodified": "2022-08-04T14:14:58.452639" }, "relationships": { "variant_set": { "meta": { "count": 8 }, "data": [ { "type": "SmallVariant", "id": "2400" }, { "type": "SmallVariant", "id": "2667" }, { "type": "SmallVariant", "id": "2774" }, { "type": "SmallVariant", "id": "2908" }, { "type": "SmallVariant", "id": "2912" }, { "type": "SmallVariant", "id": "3368" }, { "type": "SmallVariant", "id": "3373" }, { "type": "SmallVariant", "id": "3375" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOX10/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOX10/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "817" }, { "type": "GeneCombination", "id": "887" }, { "type": "GeneCombination", "id": "927" }, { "type": "GeneCombination", "id": "965" }, { "type": "GeneCombination", "id": "966" }, { "type": "GeneCombination", "id": "1131" }, { "type": "GeneCombination", "id": "1132" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOX10/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOX10/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOX10/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }