Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/224/genes/?format=api
{ "data": [ { "type": "Gene", "id": "BAZ1B", "attributes": { "go_molecular_function": [ "protein binding", "transferase activity", "kinase activity", "ATP binding", "nucleotide binding", "histone binding", "protein tyrosine kinase activity", "non-membrane spanning protein tyrosine kinase activity", "metal ion binding" ], "pathway_id": [ "R-HSA-5250913", "R-HSA-212165", "R-HSA-5250924", "R-HSA-5250924", "R-HSA-212165", "R-HSA-5250913", "R-HSA-73894", "R-HSA-5693532", "R-HSA-5693565", "R-HSA-5693606", "R-HSA-74160", "R-HSA-5693565", "R-HSA-5693606", "R-HSA-5693532", "R-HSA-73894", "R-HSA-74160" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9UIG0", "ensembl_id": "ENSG00000009954", "entrez_id": "9031", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.401888" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "698" }, { "type": "SmallVariant", "id": "710" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BAZ1B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BAZ1B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "224" }, { "type": "GeneCombination", "id": "228" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BAZ1B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BAZ1B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BAZ1B/?format=api" } }, { "type": "Gene", "id": "GRIP1", "attributes": { "go_molecular_function": [ "protein C-terminus binding", "signaling receptor complex adaptor activity", "beta-catenin binding", "protein binding" ], "pathway_id": [ "R-HSA-399719", "R-HSA-112315", "R-HSA-112316", "R-HSA-399721", "R-HSA-416993", "R-HSA-112314" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y3R0", "ensembl_id": "ENSG00000155974", "entrez_id": "23426", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.797252" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "699" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRIP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRIP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "224" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRIP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRIP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GRIP1/?format=api" } }, { "type": "Gene", "id": "SUFU", "attributes": { "go_molecular_function": [ "transcription corepressor activity" ], "pathway_id": [ "R-HSA-5358351", "R-HSA-162582", "R-HSA-5610787", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-5610780", "R-HSA-5632684", "kegg_path:hsa04340", "R-HSA-5610785", "R-HSA-5610783" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9UMX1", "ensembl_id": "ENSG00000107882", "entrez_id": "51684", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.812751" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "700" }, { "type": "SmallVariant", "id": "703" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SUFU/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SUFU/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "224" }, { "type": "GeneCombination", "id": "225" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SUFU/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SUFU/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SUFU/?format=api" } }, { "type": "Gene", "id": "TBX6", "attributes": { "go_molecular_function": [ "protein binding", "DNA binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O95947", "ensembl_id": "ENSG00000149922", "entrez_id": "6911", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.873163" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "CopyNumberVariant", "id": "61" }, { "type": "SmallVariant", "id": "701" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TBX6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TBX6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "24" }, { "type": "GeneCombination", "id": "224" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TBX6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TBX6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TBX6/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }