Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/408/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CDH23", "attributes": { "go_molecular_function": [ "['calcium ion binding', 'protein binding', 'cadherin binding']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9H251", "ensembl_id": "None", "entrez_id": "ENSG00000107736", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.400908" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "208" }, { "type": "SmallVariant", "id": "217" }, { "type": "SmallVariant", "id": "223" }, { "type": "SmallVariant", "id": "508" }, { "type": "SmallVariant", "id": "510" }, { "type": "SmallVariant", "id": "511" }, { "type": "SmallVariant", "id": "518" }, { "type": "SmallVariant", "id": "520" }, { "type": "SmallVariant", "id": "521" }, { "type": "SmallVariant", "id": "658" }, { "type": "SmallVariant", "id": "719" }, { "type": "SmallVariant", "id": "746" }, { "type": "SmallVariant", "id": "753" }, { "type": "SmallVariant", "id": "758" }, { "type": "SmallVariant", "id": "1055" }, { "type": "SmallVariant", "id": "1284" }, { "type": "SmallVariant", "id": "2234" }, { "type": "SmallVariant", "id": "2240" }, { "type": "SmallVariant", "id": "2390" }, { "type": "SmallVariant", "id": "2870" }, { "type": "SmallVariant", "id": "3543" }, { "type": "SmallVariant", "id": "3551" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDH23/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDH23/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 17 }, "data": [ { "type": "GeneCombination", "id": "81" }, { "type": "GeneCombination", "id": "75" }, { "type": "GeneCombination", "id": "79" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "171" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "345" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "814" }, { "type": "GeneCombination", "id": "813" }, { "type": "GeneCombination", "id": "812" }, { "type": "GeneCombination", "id": "810" }, { "type": "GeneCombination", "id": "1193" }, { "type": "GeneCombination", "id": "1195" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDH23/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDH23/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CDH23/?format=api" } }, { "type": "Gene", "id": "COL9A3", "attributes": { "go_molecular_function": [ "['extracellular matrix structural constituent conferring tensile strength', 'extracellular matrix structural constituent']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04974", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1474290", "R-HSA-162582", "R-HSA-1650814", "R-HSA-186797", "R-HSA-2022090", "R-HSA-216083", "R-HSA-3000178", "R-HSA-375165", "R-HSA-419037", "R-HSA-422475", "R-HSA-8948216", "R-HSA-9006934", "R-HSA-9675108" ], "essential_gene": null, "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000092758", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.594627" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1285" }, { "type": "SmallVariant", "id": "3569" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL9A3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL9A3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "1202" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL9A3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL9A3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL9A3/?format=api" } }, { "type": "Gene", "id": "MAML1", "attributes": { "go_molecular_function": [], "pathway_id": [ "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-9013508", "kegg_path:hsa04330", "R-HSA-8878159", "R-HSA-162582", "R-HSA-1980143", "R-HSA-1912408", "kegg_path:hsa04658", "R-HSA-2197563", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-212436", "R-HSA-9013694", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-1980145", "R-HSA-8941856", "R-HSA-1643685", "R-HSA-2644602", "R-HSA-2644606", "R-HSA-210744", "R-HSA-2644603", "R-HSA-2894858", "R-HSA-186712", "R-HSA-73857", "R-HSA-157118", "R-HSA-1912422", "R-HSA-2894862", "R-HSA-9012852" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q92585", "ensembl_id": "ENSG00000161021", "entrez_id": "9794", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.488997" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "721" }, { "type": "SmallVariant", "id": "1286" }, { "type": "SmallVariant", "id": "1304" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAML1/?format=api" } }, { "type": "Gene", "id": "MAMLD1", "attributes": { "go_molecular_function": [ "['molecular_function']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13495", "ensembl_id": "None", "entrez_id": "ENSG00000013619", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.997839" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "581" }, { "type": "SmallVariant", "id": "717" }, { "type": "SmallVariant", "id": "722" }, { "type": "SmallVariant", "id": "729" }, { "type": "SmallVariant", "id": "733" }, { "type": "SmallVariant", "id": "736" }, { "type": "SmallVariant", "id": "742" }, { "type": "SmallVariant", "id": "745" }, { "type": "SmallVariant", "id": "752" }, { "type": "SmallVariant", "id": "757" }, { "type": "SmallVariant", "id": "1268" }, { "type": "SmallVariant", "id": "1278" }, { "type": "SmallVariant", "id": "1280" }, { "type": "SmallVariant", "id": "1283" }, { "type": "SmallVariant", "id": "1294" }, { "type": "SmallVariant", "id": "1310" }, { "type": "SmallVariant", "id": "1316" }, { "type": "SmallVariant", "id": "3192" }, { "type": "SmallVariant", "id": "3200" }, { "type": "SmallVariant", "id": "3252" }, { "type": "SmallVariant", "id": "3259" }, { "type": "SmallVariant", "id": "3325" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "406" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1095" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/?format=api" } }, { "type": "Gene", "id": "NOTCH1", "attributes": { "go_molecular_function": [ "enzyme inhibitor activity", "calcium ion binding", "Notch binding", "chromatin DNA binding", "protein binding", "transcription coactivator activity", "transmembrane signaling receptor activity", "enzyme binding", "identical protein binding" ], "pathway_id": [ "R-HSA-2644603", "R-HSA-2894858", "R-HSA-157118", "R-HSA-1912420", "R-HSA-2660825", "R-HSA-5083630", "R-HSA-2660826", "R-HSA-1912422", "R-HSA-1643685", "kegg_path:hsa04919", "R-HSA-5668914", "kegg_path:hsa04658", "R-HSA-1266738", "R-HSA-2644607", "kegg_path:hsa05165", "R-HSA-3906995", "kegg_path:hsa01522", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-212436", "R-HSA-9013694", "R-HSA-2644605", "R-HSA-9013508", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "kegg_path:hsa05200", "R-HSA-2691230", "kegg_path:hsa04330", "R-HSA-8878159", "R-HSA-1912399", "R-HSA-1912408", "R-HSA-162582", "R-HSA-1980143", "R-HSA-186712", "R-HSA-73857", "kegg_path:hsa05020", "R-HSA-2122948", "R-HSA-2691232", "kegg_path:hsa05224", "R-HSA-2894862", "R-HSA-9012852", "R-HSA-8941856", "R-HSA-2644602", "R-HSA-3781865", "kegg_path:hsa05206", "R-HSA-210744", "R-HSA-2644606" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P46531", "ensembl_id": "ENSG00000148400", "entrez_id": "4851", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.838899" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1272" }, { "type": "SmallVariant", "id": "1287" }, { "type": "SmallVariant", "id": "1325" }, { "type": "SmallVariant", "id": "1844" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "612" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }