Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/776/genes/?format=api
{ "data": [ { "type": "Gene", "id": "PLEC", "attributes": { "go_molecular_function": [ "protein binding", "structural molecule activity", "ankyrin binding", "structural constituent of cytoskeleton", "dystroglycan binding", "RNA binding", "actin binding", "protein self-association", "cadherin binding", "structural constituent of muscle" ], "pathway_id": [ "R-HSA-446728", "R-HSA-1500931", "R-HSA-109581", "R-HSA-5357801", "R-HSA-2022090", "R-HSA-1474290", "R-HSA-264870", "R-HSA-2022090", "R-HSA-1474290", "R-HSA-264870", "R-HSA-109581", "R-HSA-5357801", "R-HSA-111465", "R-HSA-1500931", "R-HSA-1474244", "R-HSA-446107", "R-HSA-446728", "R-HSA-75153", "R-HSA-446107", "R-HSA-75153", "R-HSA-1474244", "R-HSA-111465" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15149", "ensembl_id": "ENSG00000178209", "entrez_id": "5339", "chromosome_number": "8", "lastmodified": "2022-08-04T14:14:59.833601" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2118" }, { "type": "SmallVariant", "id": "2119" }, { "type": "SmallVariant", "id": "2311" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLEC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLEC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "730" }, { "type": "GeneCombination", "id": "731" }, { "type": "GeneCombination", "id": "776" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLEC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLEC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PLEC/?format=api" } }, { "type": "Gene", "id": "RAD52", "attributes": { "go_molecular_function": [ "single-stranded DNA binding", "identical protein binding", "DNA binding", "protein binding" ], "pathway_id": [ "kegg_path:hsa03440", "R-HSA-2990846", "R-HSA-3108232", "kegg_path:hsa03440", "R-HSA-5693567", "R-HSA-5693538", "R-HSA-73894", "R-HSA-5685938", "R-HSA-5693532", "R-HSA-3108214", "R-HSA-392499", "R-HSA-597592" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P43351", "ensembl_id": "ENSG00000002016", "entrez_id": "5893", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:59.103162" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2259" }, { "type": "SmallVariant", "id": "2285" }, { "type": "SmallVariant", "id": "2310" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RAD52/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RAD52/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "761" }, { "type": "GeneCombination", "id": "767" }, { "type": "GeneCombination", "id": "776" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RAD52/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RAD52/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RAD52/?format=api" } }, { "type": "Gene", "id": "RBBP8", "attributes": { "go_molecular_function": [ "flap-structured DNA binding", "single-stranded DNA binding", "damaged DNA binding", "protein binding", "double-stranded DNA binding", "Y-form DNA binding", "identical protein binding", "transcription corepressor activity", "single-stranded DNA endodeoxyribonuclease activity", "double-strand/single-strand DNA junction binding", "RNA polymerase II-specific DNA-binding transcription factor binding" ], "pathway_id": [ "R-HSA-6804756", "R-HSA-5693579", "R-HSA-69473", "R-HSA-73894", "kegg_path:hsa03440", "R-HSA-1474165", "R-HSA-5693568", "R-HSA-5685939", "R-HSA-69620", "R-HSA-5693537", "R-HSA-5693567", "R-HSA-5693538", "R-HSA-5693607", "R-HSA-73857", "R-HSA-5633007", "R-HSA-5693554", "R-HSA-5693616", "R-HSA-1500620", "R-HSA-5685938", "R-HSA-5693532", "R-HSA-74160", "R-HSA-912446", "R-HSA-212436", "R-HSA-3700989", "R-HSA-5685942", "kegg_path:hsa03440", "R-HSA-1640170", "R-HSA-69481", "R-HSA-8953750" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q99708", "ensembl_id": "ENSG00000101773", "entrez_id": "5932", "chromosome_number": "18", "lastmodified": "2022-08-04T14:15:00.025328" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2291" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RBBP8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RBBP8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "769" }, { "type": "GeneCombination", "id": "776" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RBBP8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RBBP8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RBBP8/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }