Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/GLI3/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "236", "attributes": { "gene_relationship": [ "Involved in the same disease", "Indirectly interacting", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Gene expression (Transcription)", "Basal cell carcinoma", "RNA Polymerase II Transcription", "Pathways in cancer", "Generic Transcription Pathway", "Signaling by GPCR", "Signal Transduction" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:57.363663" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI348" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/236/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/236/combinations/?format=api" } }, "genes": { "meta": { "count": 6 }, "data": [ { "type": "Gene", "id": "CYP1A1" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "MYO7A" }, { "type": "Gene", "id": "WNT9A" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/236/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/236/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/236/?format=api" } }, { "type": "GeneCombination", "id": "232", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Gene expression (Transcription)", "Generic Transcription Pathway", "Signaling by NOTCH", "Hedgehog on state", "RUNX2 regulates bone development", "Notch-HLH transcription pathway", "Basal cell carcinoma", "NOTCH2 intracellular domain regulates transcription", "RNA Polymerase II Transcription", "Breast cancer", "Pre-NOTCH Expression and Processing", "Pre-NOTCH Transcription and Translation", "Pathways in cancer", "Signaling by NOTCH4", "Hedgehog off state", "Disease", "Hippo signaling pathway", "Signaling by NOTCH2", "Human papillomavirus infection", "Transcriptional regulation by RUNX2", "Signaling by Hedgehog", "Signal Transduction", "NOTCH4 Intracellular Domain Regulates Transcription" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:57.086935" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI344" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/232/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/232/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "GLI2" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "NOTCH2" }, { "type": "Gene", "id": "WNT9B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/232/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/232/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/232/?format=api" } }, { "type": "GeneCombination", "id": "234", "attributes": { "gene_relationship": [ "Directly interacting", "Indirectly interacting", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Gene expression (Transcription)", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Generic Transcription Pathway", "RUNX3 regulates NOTCH signaling", "Signaling by NOTCH3", "Notch-HLH transcription pathway", "NOTCH2 intracellular domain regulates transcription", "RNA Polymerase II Transcription", "Developmental Biology", "Pre-NOTCH Expression and Processing", "Pre-NOTCH Transcription and Translation", "Transcriptional regulation by RUNX3", "Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer", "Signaling by NOTCH1 PEST Domain Mutants in Cancer", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "NOTCH3 Intracellular Domain Regulates Transcription", "Regulation of beta-cell development", "Signaling by NOTCH4", "Disease", "NOTCH1 Intracellular Domain Regulates Transcription", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "Signaling by NOTCH1", "Diseases of signal transduction by growth factor receptors and second messengers", "Signaling by NOTCH2", "Signaling by NOTCH1 in Cancer", "Signal Transduction", "NOTCH4 Intracellular Domain Regulates Transcription" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:57.191228" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI346" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/234/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/234/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "MAML3" }, { "type": "Gene", "id": "MAMLD1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/234/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/234/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/234/?format=api" } }, { "type": "GeneCombination", "id": "287", "attributes": { "gene_relationship": [ "Monogenic experiments only", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Signal Transduction" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:00.672469" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI428" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/287/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/287/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "GNRHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/287/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/287/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/287/?format=api" } }, { "type": "GeneCombination", "id": "279", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Pathways in cancer" ], "genecomb_metascore": 1, "lastmodified": "2023-05-16T12:03:27.109388" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI420" }, { "type": "Combination", "id": "OLI1350" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/279/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/279/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "GLI3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/279/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/279/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/279/?format=api" } }, { "type": "GeneCombination", "id": "410", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [ "(CYP1A1, PTPN11)", "(FLNA, NRP1)", "(MAML1, MAML3)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:07.207559" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI602" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/410/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/410/combinations/?format=api" } }, "genes": { "meta": { "count": 17 }, "data": [ { "type": "Gene", "id": "BNC2" }, { "type": "Gene", "id": "NRP1" }, { "type": "Gene", "id": "PROP1" }, { "type": "Gene", "id": "PTPN11" }, { "type": "Gene", "id": "MAML1" }, { "type": "Gene", "id": "MAML3" }, { "type": "Gene", "id": "IRX5" }, { "type": "Gene", "id": "ATF3" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "IRX6" }, { "type": "Gene", "id": "CYP1A1" }, { "type": "Gene", "id": "HOXA13" }, { "type": "Gene", "id": "WDR11" }, { "type": "Gene", "id": "EYA1" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "FLNA" }, { "type": "Gene", "id": "MAMLD1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/410/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/410/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/410/?format=api" } }, { "type": "GeneCombination", "id": "926", "attributes": { "gene_relationship": [], "protein_interactions": [], "common_pathways": [ "Signal Transduction" ], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:26.947493" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1321" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/926/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/926/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "NRP2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/926/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/926/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/926/?format=api" } }, { "type": "GeneCombination", "id": "942", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Monogenic experiments only", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "Signal Transduction" ], "genecomb_metascore": 1, "lastmodified": "2023-05-16T12:03:27.083485" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1343" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/942/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/942/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "IL17RD" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/942/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/942/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/942/?format=api" } }, { "type": "GeneCombination", "id": "957", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:27.186362" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1379" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/957/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/957/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "CCDC141" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "GNRHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/957/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/957/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/957/?format=api" } }, { "type": "GeneCombination", "id": "986", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "Signal Transduction" ], "genecomb_metascore": 1, "lastmodified": "2023-05-16T12:03:27.364428" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1409" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/986/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/986/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ANOS1" }, { "type": "Gene", "id": "GLI3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/986/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/986/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/986/?format=api" } }, { "type": "GeneCombination", "id": "1061", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:27.927151" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1516" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1061/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1061/combinations/?format=api" } }, "genes": { "meta": { "count": 7 }, "data": [ { "type": "Gene", "id": "FLNA" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "NIPBL" }, { "type": "Gene", "id": "PLXNA3" }, { "type": "Gene", "id": "PROKR2" }, { "type": "Gene", "id": "SLC29A3" }, { "type": "Gene", "id": "SOX8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1061/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1061/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1061/?format=api" } }, { "type": "GeneCombination", "id": "1081", "attributes": { "gene_relationship": [], "protein_interactions": [], "common_pathways": [ "Hedgehog on state", "Basal cell carcinoma", "Generic Transcription Pathway", "GLI proteins bind promoters of Hh responsive genes to promote transcription", "RUNX2 regulates bone development", "Pathways in cancer", "RNA Polymerase II Transcription", "Transcriptional regulation by RUNX2", "Signal Transduction", "Hedgehog off state", "Gene expression (Transcription)", "Hedgehog signaling pathway", "Signaling by Hedgehog" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:28.066497" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1537" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1081/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1081/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GLI2" }, { "type": "Gene", "id": "GLI3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1081/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1081/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1081/?format=api" } }, { "type": "GeneCombination", "id": "1115", "attributes": { "gene_relationship": [], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:28.372729" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1571" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1115/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1115/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "POR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1115/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1115/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1115/?format=api" } }, { "type": "GeneCombination", "id": "1118", "attributes": { "gene_relationship": [], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:28.386463" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1574" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1118/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1118/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CTU2" }, { "type": "Gene", "id": "GLI3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1118/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1118/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1118/?format=api" } }, { "type": "GeneCombination", "id": "1120", "attributes": { "gene_relationship": [], "protein_interactions": [], "common_pathways": [ "RNA Polymerase II Transcription", "Signal Transduction", "Generic Transcription Pathway", "Gene expression (Transcription)" ], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:28.393392" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1576" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1120/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1120/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "MAMLD1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1120/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1120/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1120/?format=api" } }, { "type": "GeneCombination", "id": "1074", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2024-03-01T14:26:26.102465" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1530" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1074/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1074/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "GLI2" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "NR2F2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1074/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1074/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1074/?format=api" } } ] }