Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/NRP1/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "410", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [ "(CYP1A1, PTPN11)", "(FLNA, NRP1)", "(MAML1, MAML3)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:07.207559" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI602" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/410/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/410/combinations/?format=api" } }, "genes": { "meta": { "count": 17 }, "data": [ { "type": "Gene", "id": "BNC2" }, { "type": "Gene", "id": "NRP1" }, { "type": "Gene", "id": "PROP1" }, { "type": "Gene", "id": "PTPN11" }, { "type": "Gene", "id": "MAML1" }, { "type": "Gene", "id": "MAML3" }, { "type": "Gene", "id": "IRX5" }, { "type": "Gene", "id": "ATF3" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "IRX6" }, { "type": "Gene", "id": "CYP1A1" }, { "type": "Gene", "id": "HOXA13" }, { "type": "Gene", "id": "WDR11" }, { "type": "Gene", "id": "EYA1" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "FLNA" }, { "type": "Gene", "id": "MAMLD1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/410/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/410/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/410/?format=api" } }, { "type": "GeneCombination", "id": "446", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Monogenic experiments only", "Relevant pathways for phenotype" ], "protein_interactions": [ "(NRP1, PLXNA1)" ], "common_pathways": [ "Semaphorin interactions", "Nervous system development", "Axon guidance", "Sema3A PAK dependent Axon repulsion", "Developmental Biology", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:09.385525" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI652" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/446/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/446/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "NRP1" }, { "type": "Gene", "id": "PLXNA1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/446/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/446/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/446/?format=api" } }, { "type": "GeneCombination", "id": "624", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:19.312406" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI857" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/624/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/624/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ANOS1" }, { "type": "Gene", "id": "NRP1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/624/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/624/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/624/?format=api" } }, { "type": "GeneCombination", "id": "676", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Nervous system development", "Axon guidance", "Human papillomavirus infection", "Signaling by Receptor Tyrosine Kinases", "Developmental Biology", "PI3K-Akt signaling pathway" ], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:22.293191" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI913" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/676/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/676/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "EGF" }, { "type": "Gene", "id": "NRP1" }, { "type": "Gene", "id": "RELN" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/676/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/676/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/676/?format=api" } } ] }