Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/FRAS1/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "227", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:00:56.840797" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI339" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/227/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/227/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CHD7" }, { "type": "Gene", "id": "FRAS1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/227/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/227/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/227/?format=api" } }, { "type": "GeneCombination", "id": "236", "attributes": { "gene_relationship": [ "Involved in the same disease", "Indirectly interacting", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Gene expression (Transcription)", "Basal cell carcinoma", "RNA Polymerase II Transcription", "Pathways in cancer", "Generic Transcription Pathway", "Signaling by GPCR", "Signal Transduction" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:57.363663" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI348" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/236/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/236/combinations/?format=api" } }, "genes": { "meta": { "count": 6 }, "data": [ { "type": "Gene", "id": "CYP1A1" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "MYO7A" }, { "type": "Gene", "id": "WNT9A" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/236/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/236/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/236/?format=api" } }, { "type": "GeneCombination", "id": "238", "attributes": { "gene_relationship": [ "Involved in the same disease", "Indirectly interacting", "Directly interacting", "Relevant pathways for phenotype" ], "protein_interactions": [ "(CDH23, MYO7A)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:57.543112" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI350" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/238/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/238/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "CDH23" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "FREM2" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "MYO7A" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/238/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/238/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/238/?format=api" } }, { "type": "GeneCombination", "id": "239", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:57.649332" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI351" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/239/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/239/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "CDH23" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "MAML3" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "WNT9B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/239/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/239/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/239/?format=api" } }, { "type": "GeneCombination", "id": "240", "attributes": { "gene_relationship": [ "Involved in the same disease", "Indirectly interacting", "Directly interacting", "Relevant pathways for phenotype" ], "protein_interactions": [ "(CDH23, MYO7A)", "(MAML2, NOTCH2)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:57.806836" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI352" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/240/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/240/combinations/?format=api" } }, "genes": { "meta": { "count": 10 }, "data": [ { "type": "Gene", "id": "CDH23" }, { "type": "Gene", "id": "EVC" }, { "type": "Gene", "id": "FLNA" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "MAML2" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "MYO7A" }, { "type": "Gene", "id": "NOTCH2" }, { "type": "Gene", "id": "PIK3R3" }, { "type": "Gene", "id": "PTPN11" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/240/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/240/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/240/?format=api" } }, { "type": "GeneCombination", "id": "410", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [ "(CYP1A1, PTPN11)", "(FLNA, NRP1)", "(MAML1, MAML3)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:07.207559" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI602" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/410/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/410/combinations/?format=api" } }, "genes": { "meta": { "count": 17 }, "data": [ { "type": "Gene", "id": "BNC2" }, { "type": "Gene", "id": "NRP1" }, { "type": "Gene", "id": "PROP1" }, { "type": "Gene", "id": "PTPN11" }, { "type": "Gene", "id": "MAML1" }, { "type": "Gene", "id": "MAML3" }, { "type": "Gene", "id": "IRX5" }, { "type": "Gene", "id": "ATF3" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "IRX6" }, { "type": "Gene", "id": "CYP1A1" }, { "type": "Gene", "id": "HOXA13" }, { "type": "Gene", "id": "WDR11" }, { "type": "Gene", "id": "EYA1" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "FLNA" }, { "type": "Gene", "id": "MAMLD1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/410/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/410/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/410/?format=api" } } ] }