Variant List
This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database
GET /api/genes/PROKR2/variants/?format=api
{ "data": [ { "type": "SmallVariant", "id": "26", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": 0.0008, "KGP_genomes_AMR_maf": 0.0014, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.001, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.0005925, "gnomad_AFR_maf": 0.001292, "gnomad_AMR_maf": 0.001417, "gnomad_ASJ_maf": 0.002083, "gnomad_EAS_maf": 0.0002175, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0003692, "gnomad_OTH_maf": 0.001954, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 4.012438, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 5294763, "genomic_position_hg38": 5314117, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:40.667415", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.253C>T", "protein_change": "p.Arg85Cys", "transcript_id": "NM_144773.3", "dbsnp_id": "rs141090506", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI014" }, { "type": "Combination", "id": "OLI1110" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/26/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/26/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/26/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/26/gene/?format=api" }, "data": { "type": "Gene", "id": "PROKR2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/26/?format=api" } }, { "type": "SmallVariant", "id": "78", "attributes": { "frequencies": { "KGP_genomes_maf": 0.001, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0014, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.004, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.002299, "gnomad_AFR_maf": 0.0009229, "gnomad_AMR_maf": 0.002342, "gnomad_ASJ_maf": 0.00625, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 4.621e-05, "gnomad_NFE_maf": 0.003473, "gnomad_OTH_maf": 0.002282, "gnomad_SAS_maf": 0.000294, "ESP_AA_maf": 0.0009079, "ESP_EA_maf": 0.003488 }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.714247, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 5283323, "genomic_position_hg38": 5302677, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:40.987095", "ref_allele": "A", "alt_allele": "C", "cdna_change": "c.518T>G", "protein_change": "p.Leu173Arg", "transcript_id": "NM_144773.3", "dbsnp_id": "rs74315416", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 5 }, "data": [ { "type": "Combination", "id": "OLI036" }, { "type": "Combination", "id": "OLI119" }, { "type": "Combination", "id": "OLI152" }, { "type": "Combination", "id": "OLI205" }, { "type": "Combination", "id": "OLI206" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/78/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/78/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/78/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/78/gene/?format=api" }, "data": { "type": "Gene", "id": "PROKR2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/78/?format=api" } }, { "type": "SmallVariant", "id": "331", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 7.953e-06, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 2.891e-05, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 8.79e-06, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 4.060931, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 5294778, "genomic_position_hg38": 5314132, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.464462", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.238C>T", "protein_change": "p.Arg80Cys", "transcript_id": "NM_144773.3", "dbsnp_id": "rs774093318", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI165" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/331/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/331/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/331/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/331/gene/?format=api" }, "data": { "type": "Gene", "id": "PROKR2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/331/?format=api" } }, { "type": "SmallVariant", "id": "383", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 0.0001789, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 2.891e-05, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.000378, "gnomad_OTH_maf": 0.0001629, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.0001163 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 1.171574, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 5283237, "genomic_position_hg38": 5302591, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.768001", "ref_allele": "T", "alt_allele": "C", "cdna_change": "c.604A>G", "protein_change": "p.Ser202Gly", "transcript_id": "NM_144773.3", "dbsnp_id": "rs200755554", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI196" }, { "type": "Combination", "id": "OLI373" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/383/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/383/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/383/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/383/gene/?format=api" }, "data": { "type": "Gene", "id": "PROKR2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/383/?format=api" } }, { "type": "SmallVariant", "id": "397", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0006, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0043, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.0003261, "gnomad_AFR_maf": 6.152e-05, "gnomad_AMR_maf": 0.0004336, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 4.619e-05, "gnomad_NFE_maf": 0.0005098, "gnomad_OTH_maf": 0.00114, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.996588, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 5294762, "genomic_position_hg38": 5314116, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.855423", "ref_allele": "C", "alt_allele": "A", "cdna_change": null, "protein_change": "p.Arg85Leu", "transcript_id": null, "dbsnp_id": "rs74315418", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI204" }, { "type": "Combination", "id": "OLI648" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/397/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/397/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/397/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/397/gene/?format=api" }, "data": { "type": "Gene", "id": "PROKR2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/397/?format=api" } }, { "type": "SmallVariant", "id": "400", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0122, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.0278, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0337, "gnomad_maf": 0.006203, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0001156, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0318, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0003077, "gnomad_OTH_maf": 0.003094, "gnomad_SAS_maf": 0.02995, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.0002326 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 1.504701, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 5282850, "genomic_position_hg38": 5302204, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.874849", "ref_allele": "C", "alt_allele": "T", "cdna_change": null, "protein_change": "p.Val331Met", "transcript_id": null, "dbsnp_id": "rs117106081", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI207" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/400/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/400/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/400/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/400/gene/?format=api" }, "data": { "type": "Gene", "id": "PROKR2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/400/?format=api" } }, { "type": "SmallVariant", "id": "402", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0126, "KGP_genomes_AFR_maf": 0.0446, "KGP_genomes_AMR_maf": 0.0058, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.003911, "gnomad_AFR_maf": 0.04625, "gnomad_AMR_maf": 0.003036, "gnomad_ASJ_maf": 0.004267, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0001387, "gnomad_NFE_maf": 0.0004487, "gnomad_OTH_maf": 0.003911, "gnomad_SAS_maf": 0.000196, "ESP_AA_maf": 0.04222, "ESP_EA_maf": 0.0005814 }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 4.029314, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 5283039, "genomic_position_hg38": 5302393, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.887755", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.802C>T", "protein_change": "p.Arg268Cys", "transcript_id": "NM_144773.3", "dbsnp_id": "rs78861628", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 4 }, "data": [ { "type": "Combination", "id": "OLI208" }, { "type": "Combination", "id": "OLI285" }, { "type": "Combination", "id": "OLI286" }, { "type": "Combination", "id": "OLI689" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/402/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/402/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/402/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/402/gene/?format=api" }, "data": { "type": "Gene", "id": "PROKR2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/402/?format=api" } }, { "type": "SmallVariant", "id": "857", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0002, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.001, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 3.181e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 8.791e-06, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0002286, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.0002326 }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.469619, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 5294673, "genomic_position_hg38": 5314027, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:45.633655", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.343G>A", "protein_change": "p.Val115Met", "transcript_id": "NM_144773.3", "dbsnp_id": "rs138672528", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI396" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/857/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/857/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/857/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/857/gene/?format=api" }, "data": { "type": "Gene", "id": "PROKR2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/857/?format=api" } }, { "type": "SmallVariant", "id": "1057", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0068, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.0278, "KGP_genomes_EUR_maf": 0.005, "KGP_genomes_SAS_maf": 0.001, "gnomad_maf": 0.004489, "gnomad_AFR_maf": 0.000123, "gnomad_AMR_maf": 0.0001445, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.01952, "gnomad_FIN_maf": 0.02097, "gnomad_NFE_maf": 0.002224, "gnomad_OTH_maf": 0.002932, "gnomad_SAS_maf": 0.001241, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.001163 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 2.263874, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 5294865, "genomic_position_hg38": 5314219, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:46.862175", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.151G>A", "protein_change": "p.Ala51Thr", "transcript_id": "NM_144773.3", "dbsnp_id": "rs144994507", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI498" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1057/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1057/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1057/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1057/gene/?format=api" }, "data": { "type": "Gene", "id": "PROKR2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1057/?format=api" } }, { "type": "SmallVariant", "id": "1798", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, 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