Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/EVC/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "240", "attributes": { "gene_relationship": [ "Involved in the same disease", "Indirectly interacting", "Directly interacting", "Relevant pathways for phenotype" ], "protein_interactions": [ "(CDH23, MYO7A)", "(MAML2, NOTCH2)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:57.806836" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI352" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/240/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/240/combinations/?format=api" } }, "genes": { "meta": { "count": 10 }, "data": [ { "type": "Gene", "id": "CDH23" }, { "type": "Gene", "id": "EVC" }, { "type": "Gene", "id": "FLNA" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "MAML2" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "MYO7A" }, { "type": "Gene", "id": "NOTCH2" }, { "type": "Gene", "id": "PIK3R3" }, { "type": "Gene", "id": "PTPN11" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/240/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/240/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/240/?format=api" } }, { "type": "GeneCombination", "id": "405", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:06.720619" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI597" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/405/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/405/combinations/?format=api" } }, "genes": { "meta": { "count": 8 }, "data": [ { "type": "Gene", "id": "CYP1A1" }, { "type": "Gene", "id": "EVC" }, { "type": "Gene", "id": "GRID1" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "NOTCH1" }, { "type": "Gene", "id": "RET" }, { "type": "Gene", "id": "RIPK4" }, { "type": "Gene", "id": "ZBTB16" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/405/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/405/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/405/?format=api" } }, { "type": "GeneCombination", "id": "411", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [ "(MAML3, NOTCH2)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:07.345230" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI603" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/411/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/411/combinations/?format=api" } }, "genes": { "meta": { "count": 6 }, "data": [ { "type": "Gene", "id": "EVC" }, { "type": "Gene", "id": "MAML3" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "NOTCH2" }, { "type": "Gene", "id": "PPARGC1B" }, { "type": "Gene", "id": "WDR11" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/411/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/411/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/411/?format=api" } }, { "type": "GeneCombination", "id": "878", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Monogenic experiments only", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:39:57.019094" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1245" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/878/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/878/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "EVC" }, { "type": "Gene", "id": "WNT10A" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/878/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/878/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/878/?format=api" } } ] }