Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/WNT9B/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "23", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Same pathway", "Similar function" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:00:46.079242" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI027" }, { "type": "Combination", "id": "OLI028" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/23/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/23/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GEN1" }, { "type": "Gene", "id": "WNT9B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/23/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/23/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/23/?format=api" } }, { "type": "GeneCombination", "id": "232", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Gene expression (Transcription)", "Generic Transcription Pathway", "Signaling by NOTCH", "Hedgehog on state", "RUNX2 regulates bone development", "Notch-HLH transcription pathway", "Basal cell carcinoma", "NOTCH2 intracellular domain regulates transcription", "RNA Polymerase II Transcription", "Breast cancer", "Pre-NOTCH Expression and Processing", "Pre-NOTCH Transcription and Translation", "Pathways in cancer", "Signaling by NOTCH4", "Hedgehog off state", "Disease", "Hippo signaling pathway", "Signaling by NOTCH2", "Human papillomavirus infection", "Transcriptional regulation by RUNX2", "Signaling by Hedgehog", "Signal Transduction", "NOTCH4 Intracellular Domain Regulates Transcription" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:57.086935" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI344" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/232/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/232/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "GLI2" }, { "type": "Gene", "id": "GLI3" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "NOTCH2" }, { "type": "Gene", "id": "WNT9B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/232/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/232/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/232/?format=api" } }, { "type": "GeneCombination", "id": "239", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:57.649332" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI351" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/239/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/239/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "CDH23" }, { "type": "Gene", "id": "FRAS1" }, { "type": "Gene", "id": "MAML3" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "WNT9B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/239/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/239/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/239/?format=api" } }, { "type": "GeneCombination", "id": "412", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [ "(MAML2, NOTCH1)", "(MAML3, NOTCH1)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:07.602611" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI604" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/412/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/412/combinations/?format=api" } }, "genes": { "meta": { "count": 14 }, "data": [ { "type": "Gene", "id": "CUL4B" }, { "type": "Gene", "id": "DAPK1" }, { "type": "Gene", "id": "EMX2" }, { "type": "Gene", "id": "FREM2" }, { "type": "Gene", "id": "IGFBP2" }, { "type": "Gene", "id": "MAML2" }, { "type": "Gene", "id": "MAML3" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "MYO7A" }, { "type": "Gene", "id": "NOTCH1" }, { "type": "Gene", "id": "PIK3R3" }, { "type": "Gene", "id": "TGFBI" }, { "type": "Gene", "id": "WNT9A" }, { "type": "Gene", "id": "WNT9B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/412/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/412/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/412/?format=api" } }, { "type": "GeneCombination", "id": "832", "attributes": { "gene_relationship": [ "Monogenic experiments only", "Relevant pathways for phenotype", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2024-03-01T14:50:59.320059" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1144" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/832/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/832/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "TRIM71" }, { "type": "Gene", "id": "WNT9B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/832/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/832/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/832/?format=api" } } ] }