Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/LRP2/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "469",
            "attributes": {
                "gene_relationship": [
                    "Directly interacting",
                    "Involved in the same disease",
                    "Affecting the same tissue",
                    "Relevant pathways for phenotype",
                    "Same pathway"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:01:10.218494"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI680"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/469/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/469/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "FAT1"
                        },
                        {
                            "type": "Gene",
                            "id": "LRP2"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/469/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/469/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/469/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "475",
            "attributes": {
                "gene_relationship": [
                    "Same organelle",
                    "Affecting the same tissue",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:01:10.491713"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI686"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/475/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/475/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "CELSR1"
                        },
                        {
                            "type": "Gene",
                            "id": "LRP2"
                        },
                        {
                            "type": "Gene",
                            "id": "MKS1"
                        },
                        {
                            "type": "Gene",
                            "id": "SHH"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/475/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/475/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/475/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "686",
            "attributes": {
                "gene_relationship": [
                    "Affecting the same tissue"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 0,
                "lastmodified": "2024-03-01T15:05:06.878539"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI924"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/686/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/686/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 3
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "ERCC5"
                        },
                        {
                            "type": "Gene",
                            "id": "LRP2"
                        },
                        {
                            "type": "Gene",
                            "id": "SLC22A5"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/686/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/686/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/686/?format=api"
            }
        }
    ]
}