Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/CACNA1C/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "327", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Axon guidance", "Nervous system development", "Developmental Biology" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:02.596762" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI476" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/327/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/327/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "SHANK3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/327/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/327/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/327/?format=api" } }, { "type": "GeneCombination", "id": "331", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:02.703317" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI480" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/331/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/331/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "TSC2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/331/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/331/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/331/?format=api" } }, { "type": "GeneCombination", "id": "332", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:02.731713" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI481" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/332/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/332/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "CDKL5" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/332/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/332/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/332/?format=api" } }, { "type": "GeneCombination", "id": "333", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:02.760016" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI482" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/333/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/333/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "TSC1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/333/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/333/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/333/?format=api" } }, { "type": "GeneCombination", "id": "335", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:02.867102" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI486" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/335/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/335/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "FOXP2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/335/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/335/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/335/?format=api" } }, { "type": "GeneCombination", "id": "338", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:02.993808" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI490" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/338/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/338/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "EML1" }, { "type": "Gene", "id": "TSC1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/338/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/338/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/338/?format=api" } }, { "type": "GeneCombination", "id": "340", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:03.048589" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI492" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/340/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/340/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "MECP2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/340/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/340/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/340/?format=api" } }, { "type": "GeneCombination", "id": "341", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Developmental Biology" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:03.073590" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI493" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/341/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/341/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "HOXA1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/341/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/341/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/341/?format=api" } }, { "type": "GeneCombination", "id": "342", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:03.099059" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI494" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/342/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/342/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "GRID2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/342/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/342/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/342/?format=api" } }, { "type": "GeneCombination", "id": "439", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Monogenic experiments only", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Nervous system development", "Phase 0 - rapid depolarisation", "Muscle contraction", "Axon guidance", "Cardiac conduction", "Adrenergic signaling in cardiomyocytes" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:08.973758" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI645" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/439/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/439/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "SCN5A" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/439/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/439/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/439/?format=api" } }, { "type": "GeneCombination", "id": "441", "attributes": { "gene_relationship": [ "Indirectly interacting", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(CACNA1C, RYR2)" ], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:09.166666" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI647" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/441/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/441/combinations/?format=api" } }, "genes": { "meta": { "count": 8 }, "data": [ { "type": "Gene", "id": "AKAP9" }, { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "DSC2" }, { "type": "Gene", "id": "OBSCN" }, { "type": "Gene", "id": "RBM20" }, { "type": "Gene", "id": "RYR2" }, { "type": "Gene", "id": "TECRL" }, { "type": "Gene", "id": "VCL" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/441/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/441/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/441/?format=api" } } ] }