Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/DSC2/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "172", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Same protein complex" ], "protein_interactions": [ "(DSC2, DSG2)" ], "common_pathways": [ "Developmental Biology", "Arrhythmogenic right ventricular cardiomyopathy", "Formation of the cornified envelope" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:53.832910" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI268" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/172/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/172/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "DSC2" }, { "type": "Gene", "id": "DSG2" }, { "type": "Gene", "id": "MYH6" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/172/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/172/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/172/?format=api" } }, { "type": "GeneCombination", "id": "441", "attributes": { "gene_relationship": [ "Indirectly interacting", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(CACNA1C, RYR2)" ], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:09.166666" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI647" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/441/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/441/combinations/?format=api" } }, "genes": { "meta": { "count": 8 }, "data": [ { "type": "Gene", "id": "AKAP9" }, { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "DSC2" }, { "type": "Gene", "id": "OBSCN" }, { "type": "Gene", "id": "RBM20" }, { "type": "Gene", "id": "RYR2" }, { "type": "Gene", "id": "TECRL" }, { "type": "Gene", "id": "VCL" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/441/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/441/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/441/?format=api" } }, { "type": "GeneCombination", "id": "1275", "attributes": { "gene_relationship": [], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2024-02-29T15:02:23.921635" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1800" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1275/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1275/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "DSC2" }, { "type": "Gene", "id": "TNNT2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1275/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1275/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1275/?format=api" } } ] }