Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/RET/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "17", "attributes": { "gene_relationship": [ "Affecting the same tissue", "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(GDNF, RET)" ], "common_pathways": [ "MAPK family signaling cascades", "Nervous system development", "Calcium signaling pathway", "RET signaling", "Axon guidance", "RAF/MAP kinase cascade", "Developmental Biology", "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:45.869803" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI021" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/17/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/17/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GDNF" }, { "type": "Gene", "id": "RET" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/17/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/17/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/17/?format=api" } }, { "type": "GeneCombination", "id": "30", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Calcium signaling pathway", "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:46.332103" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI035" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/30/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/30/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "EDNRB" }, { "type": "Gene", "id": "RET" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/30/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/30/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/30/?format=api" } }, { "type": "GeneCombination", "id": "124", "attributes": { "gene_relationship": [ "Indirectly interacting" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:51.197306" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI184" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/124/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/124/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "NKX2-1" }, { "type": "Gene", "id": "RET" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/124/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/124/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/124/?format=api" } }, { "type": "GeneCombination", "id": "231", "attributes": { "gene_relationship": [ "Directly interacting", "Indirectly interacting", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(CDH23, MYO7A)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:57.016709" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI343" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/231/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/231/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "CDH23" }, { "type": "Gene", "id": "MAML1" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "MYO7A" }, { "type": "Gene", "id": "RET" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/231/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/231/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/231/?format=api" } }, { "type": "GeneCombination", "id": "235", "attributes": { "gene_relationship": [ "Directly interacting", "Indirectly interacting", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Signaling by NOTCH4", "Pre-NOTCH Expression and Processing", "Pre-NOTCH Transcription and Translation", "Gene expression (Transcription)", "Disease", "Developmental Biology", "Notch-HLH transcription pathway", "NOTCH2 intracellular domain regulates transcription", "Signaling by NOTCH2", "RNA Polymerase II Transcription", "Pathways in cancer", "Signaling by NOTCH", "Generic Transcription Pathway", "Signal Transduction", "NOTCH4 Intracellular Domain Regulates Transcription" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:57.252161" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI347" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/235/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/235/combinations/?format=api" } }, "genes": { "meta": { "count": 4 }, "data": [ { "type": "Gene", "id": "GLI2" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "NOTCH2" }, { "type": "Gene", "id": "RET" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/235/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/235/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/235/?format=api" } }, { "type": "GeneCombination", "id": "405", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:06.720619" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI597" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/405/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/405/combinations/?format=api" } }, "genes": { "meta": { "count": 8 }, "data": [ { "type": "Gene", "id": "CYP1A1" }, { "type": "Gene", "id": "EVC" }, { "type": "Gene", "id": "GRID1" }, { "type": "Gene", "id": "MAMLD1" }, { "type": "Gene", "id": "NOTCH1" }, { "type": "Gene", "id": "RET" }, { "type": "Gene", "id": "RIPK4" }, { "type": "Gene", "id": "ZBTB16" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/405/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/405/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/405/?format=api" } } ] }