Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/COL2A1/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "468",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Affecting the same tissue",
                    "Relevant pathways for phenotype",
                    "Same pathway",
                    "Monogenic experiments only"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:01:10.185595"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI679"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/468/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/468/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 3
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "COL2A1"
                        },
                        {
                            "type": "Gene",
                            "id": "FAT1"
                        },
                        {
                            "type": "Gene",
                            "id": "NDST1"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/468/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/468/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/468/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "470",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Affecting the same tissue",
                    "Relevant pathways for phenotype",
                    "Same pathway",
                    "Monogenic experiments only"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:01:10.256365"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI681"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/470/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/470/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 3
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "COL2A1"
                        },
                        {
                            "type": "Gene",
                            "id": "FAT1"
                        },
                        {
                            "type": "Gene",
                            "id": "PTCH1"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/470/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/470/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/470/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1191",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2024-02-29T15:02:22.105791"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1678"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1191/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1191/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "COL2A1"
                        },
                        {
                            "type": "Gene",
                            "id": "COL4A4"
                        },
                        {
                            "type": "Gene",
                            "id": "COL6A3"
                        },
                        {
                            "type": "Gene",
                            "id": "TTN"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1191/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1191/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1191/?format=api"
            }
        }
    ]
}