Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/COL4A4/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "28", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease", "Similar function" ], "protein_interactions": [], "common_pathways": [ "Non-integrin membrane-ECM interactions", "Integrin cell surface interactions", "Collagen formation", "Anchoring fibril formation", "Axon guidance", "Extracellular matrix organization", "Degradation of the extracellular matrix", "Crosslinking of collagen fibrils", "Signal Transduction", "Relaxin signaling pathway", "Amoebiasis", "Laminin interactions", "Protein digestion and absorption", "ECM-receptor interaction", "Pathways in cancer", "Collagen chain trimerization", "NCAM signaling for neurite out-growth", "Small cell lung cancer", "Focal adhesion", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Signaling by Receptor Tyrosine Kinases", "PI3K-Akt signaling pathway", "Human papillomavirus infection", "Nervous system development", "Developmental Biology", "Collagen degradation", "AGE-RAGE signaling pathway in diabetic complications", "Signaling by PDGF", "ECM proteoglycans", "NCAM1 interactions" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:27.160444" }, "relationships": { "combination_set": { "meta": { "count": 11 }, "data": [ { "type": "Combination", "id": "OLI033" }, { "type": "Combination", "id": "OLI383" }, { "type": "Combination", "id": "OLI384" }, { "type": "Combination", "id": "OLI385" }, { "type": "Combination", "id": "OLI386" }, { "type": "Combination", "id": "OLI387" }, { "type": "Combination", "id": "OLI388" }, { "type": "Combination", "id": "OLI1373" }, { "type": "Combination", "id": "OLI1374" }, { "type": "Combination", "id": "OLI1645" }, { "type": "Combination", "id": "OLI1647" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/28/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/28/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "COL4A4" }, { "type": "Gene", "id": "COL4A5" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/28/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/28/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/28/?format=api" } }, { "type": "GeneCombination", "id": "29", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease", "Similar function" ], "protein_interactions": [], "common_pathways": [ "Non-integrin membrane-ECM interactions", "Integrin cell surface interactions", "Collagen formation", "Anchoring fibril formation", "Axon guidance", "Extracellular matrix organization", "Degradation of the extracellular matrix", "Crosslinking of collagen fibrils", "Signal Transduction", "Relaxin signaling pathway", "Amoebiasis", "Laminin interactions", "Protein digestion and absorption", "ECM-receptor interaction", "Pathways in cancer", "Collagen chain trimerization", "NCAM signaling for neurite out-growth", "Small cell lung cancer", "Focal adhesion", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Signaling by Receptor Tyrosine Kinases", "PI3K-Akt signaling pathway", "Human papillomavirus infection", "Nervous system development", "Developmental Biology", "Collagen degradation", "AGE-RAGE signaling pathway in diabetic complications", "Signaling by PDGF", "ECM proteoglycans", "NCAM1 interactions" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:26.640911" }, "relationships": { "combination_set": { "meta": { "count": 20 }, "data": [ { "type": "Combination", "id": "OLI034" }, { "type": "Combination", "id": "OLI154" }, { "type": "Combination", "id": "OLI155" }, { "type": "Combination", "id": "OLI157" }, { "type": "Combination", "id": "OLI319" }, { "type": "Combination", "id": "OLI376" }, { "type": "Combination", "id": "OLI377" }, { "type": "Combination", "id": "OLI378" }, { "type": "Combination", "id": "OLI379" }, { "type": "Combination", "id": "OLI380" }, { "type": "Combination", "id": "OLI381" }, { "type": "Combination", "id": "OLI382" }, { "type": "Combination", "id": "OLI971" }, { "type": "Combination", "id": "OLI972" }, { "type": "Combination", "id": "OLI973" }, { "type": "Combination", "id": "OLI974" }, { "type": "Combination", "id": "OLI975" }, { "type": "Combination", "id": "OLI1247" }, { "type": "Combination", "id": "OLI1375" }, { "type": "Combination", "id": "OLI1648" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/29/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/29/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "COL4A3" }, { "type": "Gene", "id": "COL4A4" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/29/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/29/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/29/?format=api" } }, { "type": "GeneCombination", "id": "210", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Anchoring fibril formation", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "Axon guidance", "Focal adhesion", "Laminin interactions", "Assembly of collagen fibrils and other multimeric structures", "Signaling by Receptor Tyrosine Kinases", "Signaling by PDGF", "ECM-receptor interaction", "Extracellular matrix organization", "AGE-RAGE signaling pathway in diabetic complications", "Protein digestion and absorption", "Developmental Biology", "ECM proteoglycans", "Amoebiasis", "NCAM signaling for neurite out-growth", "Nervous system development", "Collagen degradation", "Collagen chain trimerization", "Degradation of the extracellular matrix", "Pathways in cancer", "Relaxin signaling pathway", "NCAM1 interactions", "Small cell lung cancer", "Crosslinking of collagen fibrils", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Human papillomavirus infection", "PI3K-Akt signaling pathway", "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:55.365076" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI318" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/210/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/210/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "COL4A3" }, { "type": "Gene", "id": "COL4A4" }, { "type": "Gene", "id": "COL4A6" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/210/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/210/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/210/?format=api" } }, { "type": "GeneCombination", "id": "1191", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2024-02-29T15:02:22.105791" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1678" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1191/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1191/combinations/?format=api" } }, "genes": { "meta": { "count": 4 }, "data": [ { "type": "Gene", "id": "COL2A1" }, { "type": "Gene", "id": "COL4A4" }, { "type": "Gene", "id": "COL6A3" }, { "type": "Gene", "id": "TTN" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1191/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1191/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1191/?format=api" } } ] }