Variant List
This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database
GET /api/genes/GNRHR/variants/?format=api
{ "data": [ { "type": "SmallVariant", "id": "330", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 2.79e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0002027, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Possibly Damaging", "cadd_prediction": 3.33248, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68619653, "genomic_position_hg38": 67753935, "chromosome": "4", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.458236", "ref_allele": "A", "alt_allele": "C", "cdna_change": "c.401T>G", "protein_change": "p.Val134Gly", "transcript_id": "NM_000406.2", "dbsnp_id": "rs188272653", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI165" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/330/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/330/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/330/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/330/gene/?format=api" }, "data": { "type": "Gene", "id": "GNRHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/330/?format=api" } }, { "type": "SmallVariant", "id": "380", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 3.979e-06, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 2.891e-05, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 2.783562, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68619807, "genomic_position_hg38": 67754089, "chromosome": "4", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.749025", "ref_allele": "G", "alt_allele": "C", "cdna_change": "c.247C>G", "protein_change": "p.Leu83Val", "transcript_id": "NM_000406.2", "dbsnp_id": "rs1391808526", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI195" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/380/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/380/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/380/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/380/gene/?format=api" }, "data": { "type": "Gene", "id": "GNRHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/380/?format=api" } }, { "type": "SmallVariant", "id": "381", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0012, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.005, "KGP_genomes_SAS_maf": 0.001, "gnomad_maf": 0.002842, "gnomad_AFR_maf": 0.0005536, "gnomad_AMR_maf": 0.002343, "gnomad_ASJ_maf": 0.005858, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.001987, "gnomad_NFE_maf": 0.004183, "gnomad_OTH_maf": 0.002935, "gnomad_SAS_maf": 0.0009472, "ESP_AA_maf": 0.0006809, "ESP_EA_maf": 0.003488 }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.003863, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68619737, "genomic_position_hg38": 67754019, "chromosome": "4", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.755387", "ref_allele": "T", "alt_allele": "C", "cdna_change": "c.317A>G", "protein_change": "p.Gln106Arg", "transcript_id": "NM_000406.2", "dbsnp_id": "rs104893836", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 14 }, "data": [ { "type": "Combination", "id": "OLI195" }, { "type": "Combination", "id": "OLI199" }, { "type": "Combination", "id": "OLI1165" }, { "type": "Combination", "id": "OLI1239" }, { "type": "Combination", "id": "OLI1275" }, { "type": "Combination", "id": "OLI1277" }, { "type": "Combination", "id": "OLI1288" }, { "type": "Combination", "id": "OLI1296" }, { "type": "Combination", "id": "OLI1300" }, { "type": "Combination", "id": "OLI1377" }, { "type": "Combination", "id": "OLI1379" }, { "type": "Combination", "id": "OLI1385" }, { "type": "Combination", "id": "OLI1532" }, { "type": "Combination", "id": "OLI1604" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/381/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/381/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/381/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/381/gene/?format=api" }, "data": { "type": "Gene", "id": "GNRHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/381/?format=api" } }, { "type": "SmallVariant", "id": "387", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0006, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.002, "KGP_genomes_SAS_maf": 0.001, "gnomad_maf": 0.001786, "gnomad_AFR_maf": 0.000123, "gnomad_AMR_maf": 0.0002313, "gnomad_ASJ_maf": 9.934e-05, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.005314, "gnomad_NFE_maf": 0.002147, "gnomad_OTH_maf": 0.002124, "gnomad_SAS_maf": 0.002156, "ESP_AA_maf": 0.000227, "ESP_EA_maf": 0.002209 }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 4.259471, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68606400, "genomic_position_hg38": 67740682, "chromosome": "4", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.792733", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.785G>A", "protein_change": "p.Arg262Gln", "transcript_id": "NM_000406.2", "dbsnp_id": "rs104893837", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 5 }, "data": [ { "type": "Combination", "id": "OLI1166" }, { "type": "Combination", "id": "OLI1403" }, { "type": "Combination", "id": "OLI1590" }, { "type": "Combination", "id": "OLI198" }, { "type": "Combination", "id": "OLI199" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/387/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/387/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/387/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/387/gene/?format=api" }, "data": { "type": "Gene", "id": "GNRHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/387/?format=api" } }, { "type": "SmallVariant", "id": "391", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 3.581e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0002602, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.96538, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68619786, "genomic_position_hg38": 67754068, "chromosome": "4", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.817731", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.268G>A", "protein_change": "p.Glu90Lys", "transcript_id": "NM_000406.2", "dbsnp_id": "rs104893844", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI201" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/391/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/391/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/391/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/391/gene/?format=api" }, "data": { "type": "Gene", "id": "GNRHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/391/?format=api" } }, { "type": "SmallVariant", "id": "401", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0014, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.0069, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.0004502, "gnomad_AFR_maf": 6.16e-05, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.004947, "gnomad_FIN_maf": 9.24e-05, "gnomad_NFE_maf": 8.821e-05, "gnomad_OTH_maf": 0.0001633, "gnomad_SAS_maf": 0.0002614, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 0.340337, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 68610309, "genomic_position_hg38": 67744591, "chromosome": "4", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.881281", "ref_allele": "C", "alt_allele": "T", "cdna_change": null, "protein_change": "p.Arg240Gln", "transcript_id": null, "dbsnp_id": "rs182531866", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 5 }, "data": [ { "type": "Combination", "id": "OLI207" }, { "type": "Combination", "id": "OLI851" }, { "type": "Combination", "id": "OLI866" }, { "type": "Combination", "id": "OLI896" }, { "type": "Combination", "id": "OLI902" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/401/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/401/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/401/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/401/gene/?format=api" }, "data": { "type": "Gene", "id": "GNRHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/401/?format=api" } }, { "type": "SmallVariant", "id": "915", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 3.740612, "mutationtaster_prediction": null }, "status": "CU", "genomic_position_hg19": 68610366, "genomic_position_hg38": 67744648, "chromosome": "4", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:45.994792", "ref_allele": "A", "alt_allele": "T", "cdna_change": "c.662T>A", "protein_change": "p.Ile221Asn", "transcript_id": "NM_000406.2", "dbsnp_id": "NA", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI428" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/915/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/915/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/915/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/915/gene/?format=api" }, "data": { "type": "Gene", "id": "GNRHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/915/?format=api" } }, { "type": "SmallVariant", "id": "1716", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 1.194e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 5.437e-05, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 1.762e-05, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.0001163 }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.433714, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68606379, "genomic_position_hg38": 67740661, "chromosome": "4", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:50.883328", "ref_allele": "G", "alt_allele": "A", "cdna_change": null, "protein_change": "p.Thr269Met", "transcript_id": null, "dbsnp_id": "rs369176613", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI780" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1716/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1716/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1716/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1716/gene/?format=api" }, "data": { "type": "Gene", "id": "GNRHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1716/?format=api" } }, { "type": "SmallVariant", "id": "2504", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0665, "KGP_genomes_AFR_maf": 0.087, "KGP_genomes_AMR_maf": 0.0908, "KGP_genomes_EAS_maf": 0.0069, "KGP_genomes_EUR_maf": 0.0815, "KGP_genomes_SAS_maf": 0.0675, "gnomad_maf": 0.0755, "gnomad_AFR_maf": 0.1042, "gnomad_AMR_maf": 0.09342, "gnomad_ASJ_maf": 0.08395, "gnomad_EAS_maf": 0.005715, "gnomad_FIN_maf": 0.03251, "gnomad_NFE_maf": 0.0905, "gnomad_OTH_maf": 0.0798, "gnomad_SAS_maf": 0.05322, "ESP_AA_maf": 0.1058, "ESP_EA_maf": 0.09919 }, "predictions": { "sift_prediction": null, "pp2_hvar_prediction": null, "cadd_prediction": 0.131336, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 68619601, "genomic_position_hg38": 67753883, "chromosome": "4", "annotation_flag": null, "lastmodified": "2023-06-06T16:57:55.642475", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.453C>T", "protein_change": "p.Ser151=", "transcript_id": null, "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1165" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/2504/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/2504/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/2504/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/2504/gene/?format=api" }, "data": { "type": "Gene", "id": "GNRHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/2504/?format=api" } }, { "type": "SmallVariant", "id": "2505", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": null, "pp2_hvar_prediction": null, "cadd_prediction": 6.242447, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68619712, 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