Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/FGFR1/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "31", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:26.719544" }, "relationships": { "combination_set": { "meta": { "count": 8 }, "data": [ { "type": "Combination", "id": "OLI036" }, { "type": "Combination", "id": "OLI196" }, { "type": "Combination", "id": "OLI204" }, { "type": "Combination", "id": "OLI833" }, { "type": "Combination", "id": "OLI1269" }, { "type": "Combination", "id": "OLI1272" }, { "type": "Combination", "id": "OLI1338" }, { "type": "Combination", "id": "OLI1356" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/31/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/31/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "PROKR2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/31/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/31/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/31/?format=api" } }, { "type": "GeneCombination", "id": "15", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2023-05-16T12:03:27.292188" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI019" }, { "type": "Combination", "id": "OLI1396" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/15/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/15/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "POLR3A" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/15/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/15/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/15/?format=api" } }, { "type": "GeneCombination", "id": "131", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway", "Co-expression" ], "protein_interactions": [ "(FGF8, FGFR1)" ], "common_pathways": [ "Ras signaling pathway", "Breast cancer", "Melanoma", "Calcium signaling pathway", "Regulation of actin cytoskeleton", "Pathways in cancer", "Rap1 signaling pathway", "PI3K-Akt signaling pathway" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:00:51.553801" }, "relationships": { "combination_set": { "meta": { "count": 5 }, "data": [ { "type": "Combination", "id": "OLI197" }, { "type": "Combination", "id": "OLI397" }, { "type": "Combination", "id": "OLI409" }, { "type": "Combination", "id": "OLI410" }, { "type": "Combination", "id": "OLI779" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/131/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/131/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FGF8" }, { "type": "Gene", "id": "FGFR1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/131/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/131/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/131/?format=api" } }, { "type": "GeneCombination", "id": "252", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway", "Co-expression" ], "protein_interactions": [ "(FGF17, FGFR1)" ], "common_pathways": [ "Ras signaling pathway", "Breast cancer", "Melanoma", "Calcium signaling pathway", "Pathways in cancer", "Rap1 signaling pathway", "PI3K-Akt signaling pathway" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:58.487886" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI367" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/252/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/252/combinations/?format=api" } }, "genes": { "meta": { "count": 4 }, "data": [ { "type": "Gene", "id": "FGF17" }, { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "FLRT3" }, { "type": "Gene", "id": "HS6ST1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/252/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/252/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/252/?format=api" } }, { "type": "GeneCombination", "id": "253", "attributes": { "gene_relationship": [ "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway", "Monogenic experiments only", "Co-expression" ], "protein_interactions": [], "common_pathways": [ "Disease", "Diseases of signal transduction by growth factor receptors and second messengers" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:58.521585" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI368" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/253/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/253/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "DUSP6" }, { "type": "Gene", "id": "FGFR1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/253/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/253/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/253/?format=api" } }, { "type": "GeneCombination", "id": "257", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "GPCR downstream signalling", "Class A/1 (Rhodopsin-like receptors)", "Signaling by GPCR", "Signal Transduction", "GPCR ligand binding" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:58.665277" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI373" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/257/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/257/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "GNRH1" }, { "type": "Gene", "id": "PROKR2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/257/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/257/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/257/?format=api" } }, { "type": "GeneCombination", "id": "259", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:58.827956" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI375" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/259/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/259/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "KISS1R" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/259/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/259/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/259/?format=api" } }, { "type": "GeneCombination", "id": "258", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "Calcium signaling pathway" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:26.793521" }, "relationships": { "combination_set": { "meta": { "count": 3 }, "data": [ { "type": "Combination", "id": "OLI374" }, { "type": "Combination", "id": "OLI392" }, { "type": "Combination", "id": "OLI1290" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/258/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/258/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "TACR3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/258/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/258/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/258/?format=api" } }, { "type": "GeneCombination", "id": "261", "attributes": { "gene_relationship": [ "Directly interacting", "Relevant pathways for phenotype", "Involved in the same disease" ], "protein_interactions": [ "(ANOS1, FGFR1)" ], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:27.066152" }, "relationships": { "combination_set": { "meta": { "count": 4 }, "data": [ { "type": "Combination", "id": "OLI391" }, { "type": "Combination", "id": "OLI456" }, { "type": "Combination", "id": "OLI1106" }, { "type": "Combination", "id": "OLI1339" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/261/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/261/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ANOS1" }, { "type": "Gene", "id": "FGFR1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/261/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/261/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/261/?format=api" } }, { "type": "GeneCombination", "id": "255", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:27.070520" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI371" }, { "type": "Combination", "id": "OLI835" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/255/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/255/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "SPRY4" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/255/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/255/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/255/?format=api" } }, { "type": "GeneCombination", "id": "279", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Pathways in cancer" ], "genecomb_metascore": 1, "lastmodified": "2023-05-16T12:03:27.109388" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI420" }, { "type": "Combination", "id": "OLI1350" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/279/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/279/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "GLI3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/279/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/279/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/279/?format=api" } }, { "type": "GeneCombination", "id": "370", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Ras signaling pathway", "Breast cancer", "Central carbon metabolism in cancer", "Melanoma", "Disease", "Calcium signaling pathway", "Proteoglycans in cancer", "Diseases of signal transduction by growth factor receptors and second messengers", "secretion and action", "Pathways in cancer", "Parathyroid hormone synthesis", "Regulation of actin cytoskeleton", "Rap1 signaling pathway", "PI3K-Akt signaling pathway", "Adherens junction", "Prostate cancer" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:04.964838" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI554" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/370/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/370/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "EGFR" }, { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "MDGA1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/370/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/370/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/370/?format=api" } }, { "type": "GeneCombination", "id": "446", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Monogenic experiments only", "Relevant pathways for phenotype" ], "protein_interactions": [ "(NRP1, PLXNA1)" ], "common_pathways": [ "Semaphorin interactions", "Nervous system development", "Axon guidance", "Sema3A PAK dependent Axon repulsion", "Developmental Biology", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:09.385525" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI652" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/446/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/446/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "NRP1" }, { "type": "Gene", "id": "PLXNA1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/446/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/446/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/446/?format=api" } }, { "type": "GeneCombination", "id": "478", "attributes": { "gene_relationship": [ "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:10.630832" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI689" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/478/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/478/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "CHD7" }, { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "PROKR2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/478/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/478/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/478/?format=api" } }, { "type": "GeneCombination", "id": "613", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Pathways in cancer" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:18.802352" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI844" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/613/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/613/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "CCDC88C" }, { "type": "Gene", "id": "DCC" }, { "type": "Gene", "id": "FGFR1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/613/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/613/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/613/?format=api" } }, { "type": "GeneCombination", "id": "625", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [ "(FGFR1, IL17RD)" ], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:19.358396" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI858" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/625/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/625/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "IL17RD" }, { "type": "Gene", "id": "LHB" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/625/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/625/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/625/?format=api" } }, { "type": "GeneCombination", "id": "672", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Disease", "Metabolism of proteins", "Post-translational protein modification", "Metabolism" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:22.152152" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI909" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/672/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/672/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "B4GAT1" }, { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "LHB" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/672/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/672/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/672/?format=api" } }, { "type": "GeneCombination", "id": "891", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Same pathway", "Involved in the same disease" ], "protein_interactions": [ "(FGFR1, IL17RD)" ], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2023-05-16T12:03:26.714985" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1268" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/891/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/891/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "CHD7" }, { "type": "Gene", "id": "FGFR1" }, { "type": "Gene", "id": "IL17RD" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/891/relationships/genes?format=api", "related": 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