Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/PRKN/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "96", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway", "Same organelle" ], "protein_interactions": [ "(PINK1, PRKN)" ], "common_pathways": [ "Selective autophagy", "PINK1-PRKN Mediated Mitophagy", "Pathways of neurodegeneration - multiple diseases", "Mitophagy", "Amyotrophic lateral sclerosis", "Macroautophagy", "Autophagy" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:00:49.478480" }, "relationships": { "combination_set": { "meta": { "count": 6 }, "data": [ { "type": "Combination", "id": "OLI128" }, { "type": "Combination", "id": "OLI129" }, { "type": "Combination", "id": "OLI127" }, { "type": "Combination", "id": "OLI228" }, { "type": "Combination", "id": "OLI229" }, { "type": "Combination", "id": "OLI230" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/96/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/96/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "PINK1" }, { "type": "Gene", "id": "PRKN" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/96/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/96/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/96/?format=api" } }, { "type": "GeneCombination", "id": "917", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [ "(GBA, PRKN)", "(PRKN, TARDBP)" ], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:26.896576" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1310" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/917/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/917/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "GBA" }, { "type": "Gene", "id": "PRKN" }, { "type": "Gene", "id": "TARDBP" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/917/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/917/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/917/?format=api" } }, { "type": "GeneCombination", "id": "918", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [ "(GBA, PRKN)" ], "common_pathways": [ "Metabolism of proteins" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:26.900845" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1311" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/918/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/918/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GBA" }, { "type": "Gene", "id": "PRKN" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/918/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/918/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/918/?format=api" } }, { "type": "GeneCombination", "id": "919", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [ "(LRRK2, PRKN)", "(PRKN, TARDBP)" ], "common_pathways": [ "Pathways of neurodegeneration - multiple diseases" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:26.907416" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1312" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/919/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/919/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "LRRK2" }, { "type": "Gene", "id": "PRKN" }, { "type": "Gene", "id": "TARDBP" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/919/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/919/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/919/?format=api" } } ] }