Gene Instance
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genes/APOE/?format=api
{ "data": { "type": "Gene", "id": "APOE", "attributes": { "go_molecular_function": [ "['lipid binding', 'protein binding', 'tau protein binding', 'structural molecule activity', 'identical protein binding', 'amyloid-beta binding', 'metal chelating activity', 'low-density lipoprotein particle receptor binding', 'lipoprotein particle binding', 'very-low-density lipoprotein particle receptor binding', 'heparin binding', 'protein homodimerization activity', 'phospholipid binding', 'cholesterol transfer activity', 'phosphatidylcholine-sterol O-acyltransferase activator activity', 'protein-containing complex binding', 'signaling receptor binding', 'protein dimerization activity', 'lipid transporter activity', 'heparan sulfate proteoglycan binding', 'antioxidant activity']" ], "pathway_id": [ "kegg_path:hsa04979", "kegg_path:hsa05010", "kegg_path:hsa04979", "kegg_path:hsa05010", "R-HSA-1236394", "R-HSA-1251985", "R-HSA-1430728", "R-HSA-162582", "R-HSA-174824", "R-HSA-196854", "R-HSA-212436", "R-HSA-2173782", "R-HSA-2187338", "R-HSA-3000480", "R-HSA-372790", "R-HSA-381426", "R-HSA-382551", "R-HSA-388396", "R-HSA-392499", "R-HSA-418594", "R-HSA-5653656", "R-HSA-597592", "R-HSA-6806667", "R-HSA-73857", "R-HSA-74160", "R-HSA-8864260", "R-HSA-8957275", "R-HSA-8963888", "R-HSA-8963898", "R-HSA-8963899", "R-HSA-8963901", "R-HSA-8964026", "R-HSA-8964043", "R-HSA-8964058", "R-HSA-9006931", "R-HSA-9006934", "R-HSA-9024446", "R-HSA-9029569", "R-HSA-975634" ], "essential_gene": "Non-essential", "status": null, "uniprot_acc": "P02649", "ensembl_id": "None", "entrez_id": "ENSG00000130203", "chromosome_number": "19" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3100" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/APOE/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/APOE/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1038" }, { "type": "GeneCombination", "id": "1039" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/APOE/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/APOE/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/APOE/?format=api" } }, "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "lastmodified": "2023-05-16T12:02:33.350420", "status": "CU", "curator": null, "submitter": "cnachteg" } }