Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/SORL1/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "879",
            "attributes": {
                "gene_relationship": [
                    "Relevant pathways for phenotype",
                    "Monogenic experiments only"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2024-03-01T14:39:41.273492"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1246"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/879/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/879/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "ATP7B"
                        },
                        {
                            "type": "Gene",
                            "id": "FOXP1"
                        },
                        {
                            "type": "Gene",
                            "id": "SETX"
                        },
                        {
                            "type": "Gene",
                            "id": "SORL1"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/879/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/879/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/879/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1038",
            "attributes": {
                "gene_relationship": [
                    "Relevant pathways for phenotype",
                    "Involved in the same disease",
                    "Directly interacting"
                ],
                "protein_interactions": [
                    "(APOE, MAPT)",
                    "(APOE, PSEN1)",
                    "(APOE, SORL1)",
                    "(MAPT, PSEN1)"
                ],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2023-05-16T12:03:27.649143"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1470"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1038/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1038/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 5
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "APOE"
                        },
                        {
                            "type": "Gene",
                            "id": "CHAT"
                        },
                        {
                            "type": "Gene",
                            "id": "MAPT"
                        },
                        {
                            "type": "Gene",
                            "id": "PSEN1"
                        },
                        {
                            "type": "Gene",
                            "id": "SORL1"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1038/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1038/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1038/?format=api"
            }
        }
    ]
}