Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/TPO/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "26", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Metabolism of amine-derived hormones", "Thyroxine biosynthesis", "Thyroid hormone synthesis", "Metabolism of amino acids and derivatives" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:46.216302" }, "relationships": { "combination_set": { "meta": { "count": 3 }, "data": [ { "type": "Combination", "id": "OLI031" }, { "type": "Combination", "id": "OLI468" }, { "type": "Combination", "id": "OLI474" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/26/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/26/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "DUOX2" }, { "type": "Gene", "id": "TG" }, { "type": "Gene", "id": "TPO" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/26/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/26/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/26/?format=api" } }, { "type": "GeneCombination", "id": "322", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Thyroid hormone synthesis" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:02.335306" }, "relationships": { "combination_set": { "meta": { "count": 6 }, "data": [ { "type": "Combination", "id": "OLI469" }, { "type": "Combination", "id": "OLI519" }, { "type": "Combination", "id": "OLI587" }, { "type": "Combination", "id": "OLI995" }, { "type": "Combination", "id": "OLI1025" }, { "type": "Combination", "id": "OLI1026" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/322/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/322/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "TG" }, { "type": "Gene", "id": "TPO" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/322/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/322/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/322/?format=api" } }, { "type": "GeneCombination", "id": "324", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Autoimmune thyroid disease", "Thyroid hormone synthesis" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:02.436479" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI471" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/324/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/324/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "TPO" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/324/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/324/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/324/?format=api" } }, { "type": "GeneCombination", "id": "325", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:02.463434" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI472" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/325/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/325/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GLIS3" }, { "type": "Gene", "id": "TPO" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/325/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/325/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/325/?format=api" } }, { "type": "GeneCombination", "id": "397", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Disease", "Autoimmune thyroid disease", "Thyroid hormone synthesis" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:06.248593" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI586" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/397/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/397/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "SLC26A4" }, { "type": "Gene", "id": "TPO" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/397/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/397/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/397/?format=api" } }, { "type": "GeneCombination", "id": "402", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Metabolism of amine-derived hormones", "Thyroxine biosynthesis", "Metabolism of amino acids and derivatives", "Thyroid hormone synthesis" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:06.545418" }, "relationships": { "combination_set": { "meta": { "count": 3 }, "data": [ { "type": "Combination", "id": "OLI594" }, { "type": "Combination", "id": "OLI1020" }, { "type": "Combination", "id": "OLI1805" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/402/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/402/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "DUOX2" }, { "type": "Gene", "id": "TPO" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/402/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/402/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/402/?format=api" } }, { "type": "GeneCombination", "id": "806", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2023-05-16T12:03:27.821146" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI1091" }, { "type": "Combination", "id": "OLI1505" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/806/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/806/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "DUOXA2" }, { "type": "Gene", "id": "HES1" }, { "type": "Gene", "id": "TPO" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/806/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/806/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/806/?format=api" } }, { "type": "GeneCombination", "id": "856", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Monogenic experiments only", "Affecting the same tissue", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Thyroid hormone synthesis" ], "genecomb_metascore": 1, "lastmodified": "2024-03-01T14:45:17.084092" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1174" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/856/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/856/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "DUOXA2" }, { "type": "Gene", "id": "TPO" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/856/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/856/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/856/?format=api" } }, { "type": "GeneCombination", "id": "855", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Thyroid hormone synthesis" ], "genecomb_metascore": 1, "lastmodified": "2024-03-01T14:50:17.299019" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1173" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/855/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/855/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "SLC26A4" }, { "type": "Gene", "id": "TPO" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/855/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/855/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/855/?format=api" } }, { "type": "GeneCombination", "id": "1050", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:27.730617" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1490" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1050/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1050/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "EYA1" }, { "type": "Gene", "id": "TPO" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1050/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1050/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1050/?format=api" } }, { "type": "GeneCombination", "id": "1135", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "Metabolic pathways" ], "genecomb_metascore": 1, "lastmodified": "2023-05-16T12:03:28.490881" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1607" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1135/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1135/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "KMT2D" }, { "type": "Gene", "id": "TPO" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1135/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1135/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1135/?format=api" } } ] }