Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/PCSK9/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "317", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(APOB, MTTP)" ], "common_pathways": [ "Post-translational protein phosphorylation", "and clearance", "Plasma lipoprotein assembly", "Fat digestion and absorption", "Transport of small molecules", "Metabolism of proteins", "Plasma lipoprotein clearance", "Chylomicron assembly", "Cholesterol metabolism", "Membrane Trafficking", "Immune System", "Vesicle-mediated transport", "Post-translational protein modification", "Plasma lipoprotein remodeling", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Plasma lipoprotein assembly", "remodeling", "Metabolism", "LDL clearance", "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:02.070003" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI463" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/317/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/317/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "ANGPTL3" }, { "type": "Gene", "id": "APOB" }, { "type": "Gene", "id": "MTTP" }, { "type": "Gene", "id": "PCSK9" }, { "type": "Gene", "id": "SAR1B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/317/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/317/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/317/?format=api" } }, { "type": "GeneCombination", "id": "347", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(LDLR, PCSK9)" ], "common_pathways": [ "Plasma lipoprotein assembly", "and clearance", "Cholesterol metabolism", "Transport of small molecules", "remodeling", "LDL clearance", "Plasma lipoprotein clearance" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:03.412298" }, "relationships": { "combination_set": { "meta": { "count": 6 }, "data": [ { "type": "Combination", "id": "OLI500" }, { "type": "Combination", "id": "OLI817" }, { "type": "Combination", "id": "OLI818" }, { "type": "Combination", "id": "OLI819" }, { "type": "Combination", "id": "OLI820" }, { "type": "Combination", "id": "OLI821" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/347/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/347/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "LDLR" }, { "type": "Gene", "id": "PCSK9" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/347/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/347/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/347/?format=api" } }, { "type": "GeneCombination", "id": "860", "attributes": { "gene_relationship": [ "Monogenic experiments only", "Indirectly interacting", "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Cholesterol metabolism" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:41:27.239338" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1215" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/860/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/860/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "ABCG5" }, { "type": "Gene", "id": "CD36" }, { "type": "Gene", "id": "PCSK9" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/860/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/860/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/860/?format=api" } } ] }