Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/BBS2/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "33", "attributes": { "gene_relationship": [ "Affecting the same tissue", "Colocalization", "Directly interacting" ], "protein_interactions": [ "(BBS2, CCDC28B)" ], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:46.501145" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI041" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/33/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/33/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "CCDC28B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/33/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/33/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/33/?format=api" } }, { "type": "GeneCombination", "id": "46", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway", "Monogenic experiments only" ], "protein_interactions": [ "(BBS1, BBS2)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:47.239871" }, "relationships": { "combination_set": { "meta": { "count": 5 }, "data": [ { "type": "Combination", "id": "OLI064" }, { "type": "Combination", "id": "OLI065" }, { "type": "Combination", "id": "OLI139" }, { "type": "Combination", "id": "OLI417" }, { "type": "Combination", "id": "OLI1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/46/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/46/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS1" }, { "type": "Gene", "id": "BBS2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/46/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/46/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/46/?format=api" } }, { "type": "GeneCombination", "id": "47", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Monogenic experiments only", "Same pathway" ], "protein_interactions": [ "(BBS2, MKKS)" ], "common_pathways": [ "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:47.353260" }, "relationships": { "combination_set": { "meta": { "count": 6 }, "data": [ { "type": "Combination", "id": "OLI067" }, { "type": "Combination", "id": "OLI170" }, { "type": "Combination", "id": "OLI171" }, { "type": "Combination", "id": "OLI225" }, { "type": "Combination", "id": "OLI226" }, { "type": "Combination", "id": "OLI224" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/47/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/47/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/47/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/47/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/47/?format=api" } }, { "type": "GeneCombination", "id": "59", "attributes": { "gene_relationship": [ "Involved in the same disease", "Similar function", "Directly interacting", "Relevant pathways for phenotype" ], "protein_interactions": [ "(BBS12, BBS4)", "(BBS2, BBS4)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:47.861759" }, "relationships": { "combination_set": { "meta": { "count": 4 }, "data": [ { "type": "Combination", "id": "OLI081" }, { "type": "Combination", "id": "OLI082" }, { "type": "Combination", "id": "OLI1121" }, { "type": "Combination", "id": "OLI1132" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/59/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/59/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS12" }, { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "BBS4" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/59/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/59/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/59/?format=api" } }, { "type": "GeneCombination", "id": "73", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Affecting the same tissue", "Same pathway", "Similar function" ], "protein_interactions": [ "(BBS2, BBS7)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:48.504647" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI098" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/73/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/73/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "BBS7" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/73/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/73/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/73/?format=api" } }, { "type": "GeneCombination", "id": "94", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Directly interacting", "Same pathway" ], "protein_interactions": [ "(BBS2, BBS4)" ], "common_pathways": [ "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:49.373199" }, "relationships": { "combination_set": { "meta": { "count": 3 }, "data": [ { "type": "Combination", "id": "OLI124" }, { "type": "Combination", "id": "OLI125" }, { "type": "Combination", "id": "OLI1229" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/94/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/94/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "BBS4" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/94/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/94/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/94/?format=api" } }, { "type": "GeneCombination", "id": "106", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Monogenic experiments only", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:50.055377" }, "relationships": { "combination_set": { "meta": { "count": 3 }, "data": [ { "type": "Combination", "id": "OLI144" }, { "type": "Combination", "id": "OLI172" }, { "type": "Combination", "id": "OLI176" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/106/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/106/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS10" }, { "type": "Gene", "id": "BBS2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/106/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/106/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/106/?format=api" } }, { "type": "GeneCombination", "id": "121", "attributes": { "gene_relationship": [ "Involved in the same disease", "Monogenic experiments only", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Cilium Assembly", "Organelle biogenesis and maintenance" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:50.872004" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI173" }, { "type": "Combination", "id": "OLI174" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/121/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/121/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS12" }, { "type": "Gene", "id": "BBS2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/121/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/121/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/121/?format=api" } }, { "type": "GeneCombination", "id": "212", "attributes": { "gene_relationship": [ "Involved in the same disease", "Indirectly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:55.482978" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI322" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/212/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/212/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS12" }, { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "INPP5E" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/212/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/212/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/212/?format=api" } }, { "type": "GeneCombination", "id": "214", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(BBS2, BBS4)", "(BBS2, TTC8)", "(BBS4, TTC8)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:55.599924" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI325" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/214/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/214/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/214/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/214/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/214/?format=api" } }, { "type": "GeneCombination", "id": "420", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(BBS2, BBS4)", "(BBS2, MKKS)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:01:08.022498" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI614" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/420/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/420/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/420/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/420/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/420/?format=api" } }, { "type": "GeneCombination", "id": "422", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Cilium Assembly", "Organelle biogenesis and maintenance" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:01:08.091955" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI616" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/422/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/422/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "NPHP1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/422/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/422/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/422/?format=api" } }, { "type": "GeneCombination", "id": "605", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(BBS2, BBS4)", "(BBS4, KIF7)" ], "common_pathways": [ "Cilium Assembly", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:18.368854" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI832" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/605/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/605/combinations/?format=api" } }, "genes": { "meta": { "count": 4 }, "data": [ { "type": "Gene", "id": "AHI1" }, { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "KIF7" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/605/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/605/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/605/?format=api" } }, { "type": "GeneCombination", "id": "684", "attributes": { "gene_relationship": [ "Same organelle" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2022-08-04T14:15:00.305504" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI922" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/684/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/684/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "CRB2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/684/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/684/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/684/?format=api" } }, { "type": "GeneCombination", "id": "1015", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:27.525502" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1446" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1015/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1015/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "CORO2B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1015/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1015/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1015/?format=api" } }, { "type": "GeneCombination", "id": "1016", "attributes": { "gene_relationship": [ "Colocalization", "Same pathway", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "Organelle biogenesis and maintenance", "Cilium Assembly" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:21:32.468294" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1447" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1016/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1016/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "MKS1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1016/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1016/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1016/?format=api" } } ] }