Variant List
This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database
GET /api/genes/NOD2/variants/?format=api
{ "data": [ { "type": "SmallVariant", "id": "269", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 2.784e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 6.155e-05, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": 0.0002275, "ESP_EA_maf": 0.0 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Possibly Damaging", "cadd_prediction": 2.552251, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 50757270, "genomic_position_hg38": 50723359, "chromosome": "16", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.105902", "ref_allele": "A", "alt_allele": "G", "cdna_change": "c.2857A>G", "protein_change": "p.Lys953Glu", "transcript_id": "NM_022162.2", "dbsnp_id": "rs375705174", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI130" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/269/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/269/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/269/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/269/gene/?format=api" }, "data": { "type": "Gene", "id": "NOD2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/269/?format=api" } }, { "type": "SmallVariant", "id": "2628", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 0.0001472, "gnomad_AFR_maf": 0.000123, "gnomad_AMR_maf": 5.782e-05, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0002638, "gnomad_OTH_maf": 0.0003258, "gnomad_SAS_maf": 3.266e-05, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 2.644028, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 50745012, "genomic_position_hg38": 50711101, "chromosome": "16", "annotation_flag": null, "lastmodified": "2023-06-06T16:57:56.262332", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.1190C>T", "protein_change": "p.Pro397Leu", "transcript_id": null, "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1241" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/2628/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/2628/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/2628/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/2628/gene/?format=api" }, "data": { "type": "Gene", "id": "NOD2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/2628/?format=api" } }, { "type": "SmallVariant", "id": "3714", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0517, "KGP_genomes_AFR_maf": 0.0121, "KGP_genomes_AMR_maf": 0.0937, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.159, "KGP_genomes_SAS_maf": 0.0184, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": null, "pp2_hvar_prediction": null, "cadd_prediction": 0.076201, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 50756774, "genomic_position_hg38": 50722863, "chromosome": "16", "annotation_flag": null, "lastmodified": "2024-02-29T15:02:34.438244", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.2798+158C>T", "protein_change": null, "transcript_id": "NM_022162.1", "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 25 }, "data": [ { "type": "Combination", "id": "OLI1750" }, { "type": "Combination", "id": "OLI1751" }, { "type": "Combination", "id": "OLI1754" }, { "type": "Combination", "id": "OLI1755" }, { "type": "Combination", "id": "OLI1756" }, { "type": "Combination", "id": "OLI1757" }, { "type": "Combination", "id": "OLI1762" }, { "type": "Combination", "id": "OLI1763" }, { "type": "Combination", "id": "OLI1764" }, { "type": "Combination", "id": "OLI1765" }, { "type": "Combination", "id": "OLI1767" }, { "type": "Combination", "id": "OLI1768" }, { "type": "Combination", "id": "OLI1769" }, { "type": "Combination", "id": "OLI1770" }, { "type": "Combination", "id": "OLI1773" }, { "type": "Combination", "id": "OLI1774" }, { "type": "Combination", "id": "OLI1776" }, { "type": "Combination", "id": "OLI1778" }, { "type": "Combination", "id": "OLI1780" }, { "type": "Combination", "id": "OLI1781" }, { "type": "Combination", "id": "OLI1782" }, { "type": "Combination", "id": "OLI1785" }, { "type": "Combination", "id": "OLI1786" }, { "type": "Combination", "id": "OLI1787" }, { "type": "Combination", "id": "OLI1789" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/3714/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/3714/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/3714/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/3714/gene/?format=api" }, "data": { "type": "Gene", "id": "NOD2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/3714/?format=api" } }, { "type": "SmallVariant", "id": "3716", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": null, "pp2_hvar_prediction": null, "cadd_prediction": 5.602728, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 50763781, "genomic_position_hg38": 50729870, "chromosome": "16", "annotation_flag": null, "lastmodified": "2024-02-29T15:02:34.509947", "ref_allele": "C", "alt_allele": "CC", "cdna_change": "c.3019dup", "protein_change": "p.Leu1007fs", "transcript_id": "NM_022162.1", "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 7 }, "data": [ { "type": "Combination", "id": "OLI1751" }, { "type": "Combination", "id": "OLI1755" }, { "type": "Combination", "id": "OLI1759" }, { "type": "Combination", "id": "OLI1760" }, { "type": "Combination", "id": "OLI1767" }, { "type": "Combination", "id": "OLI1773" }, { "type": "Combination", "id": "OLI1789" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/3716/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/3716/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/3716/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/3716/gene/?format=api" }, "data": { "type": "Gene", "id": "NOD2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/3716/?format=api" } }, { "type": "SmallVariant", "id": "3718", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0184, "KGP_genomes_AFR_maf": 0.0673, "KGP_genomes_AMR_maf": 0.0043, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.003246, "gnomad_AFR_maf": 0.04475, "gnomad_AMR_maf": 0.001937, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.000106, "gnomad_OTH_maf": 0.001306, "gnomad_SAS_maf": 6.534e-05, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 1.159966, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 50745996, "genomic_position_hg38": 50712085, "chromosome": "16", "annotation_flag": null, "lastmodified": "2024-02-29T15:02:34.584304", "ref_allele": "C", "alt_allele": "G", "cdna_change": "c.2174C>G", "protein_change": "p.Ala725Gly", "transcript_id": "NM_022162.3", "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1752" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/3718/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/3718/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/3718/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/3718/gene/?format=api" }, "data": { "type": "Gene", "id": "NOD2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/3718/?format=api" } }, { "type": "SmallVariant", "id": "3719", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0002, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.001, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.0006825, "gnomad_AFR_maf": 0.0002462, "gnomad_AMR_maf": 0.0002024, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 9.565e-05, "gnomad_NFE_maf": 0.001364, "gnomad_OTH_maf": 0.0004905, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 1.069874, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 50733785, "genomic_position_hg38": 50699874, "chromosome": "16", "annotation_flag": null, "lastmodified": "2024-02-29T15:02:34.639655", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.460G>A", "protein_change": "p.Asp154Asn", "transcript_id": "NM_022162.3", "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1753" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/3719/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/3719/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/3719/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/3719/gene/?format=api" }, "data": { "type": "Gene", "id": "NOD2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/3719/?format=api" } }, { "type": "SmallVariant", "id": "3724", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0002, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.001, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.001603, "gnomad_AFR_maf": 0.0002462, "gnomad_AMR_maf": 0.0008384, "gnomad_ASJ_maf": 0.009333, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0009793, "gnomad_NFE_maf": 0.002088, "gnomad_OTH_maf": 0.001795, "gnomad_SAS_maf": 0.0002287, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": -0.322153, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 50746194, "genomic_position_hg38": 50712283, "chromosome": "16", "annotation_flag": null, "lastmodified": "2024-02-29T15:02:34.867530", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.2372G>A", "protein_change": "p.Arg791Gln", "transcript_id": "NM_022162.3", "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI1756" }, { "type": "Combination", "id": "OLI1788" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/3724/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/3724/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/3724/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/3724/gene/?format=api" }, "data": { "type": "Gene", "id": "NOD2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/3724/?format=api" } }, { "type": "SmallVariant", "id": "3725", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0144, "KGP_genomes_AFR_maf": 0.0023, "KGP_genomes_AMR_maf": 0.0245, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.0507, "KGP_genomes_SAS_maf": 0.001, "gnomad_maf": 0.02605, "gnomad_AFR_maf": 0.006992, "gnomad_AMR_maf": 0.02024, "gnomad_ASJ_maf": 0.0223, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.01873, "gnomad_NFE_maf": 0.04329, "gnomad_OTH_maf": 0.03045, "gnomad_SAS_maf": 0.0003925, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Possibly Damaging", "cadd_prediction": 3.325543, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 50745926, "genomic_position_hg38": 50712015, "chromosome": "16", "annotation_flag": null, "lastmodified": "2024-02-29T15:02:34.934151", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.2104C>T", "protein_change": "p.Arg702Trp", "transcript_id": "NM_022162.3", "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 10 }, "data": [ { "type": "Combination", "id": "OLI1757" }, { "type": "Combination", "id": "OLI1762" }, { "type": "Combination", "id": "OLI1765" }, { "type": "Combination", "id": "OLI1768" }, { "type": "Combination", "id": "OLI1770" }, { "type": "Combination", "id": "OLI1774" }, { "type": "Combination", "id": "OLI1776" }, { "type": "Combination", "id": "OLI1779" }, { "type": "Combination", "id": "OLI1780" }, { "type": "Combination", "id": "OLI1786" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/3725/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/3725/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/3725/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/3725/gene/?format=api" }, "data": { "type": "Gene", "id": "NOD2" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/3725/?format=api" } }, { "type": "SmallVariant", "id": "3726", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0333, "KGP_genomes_AFR_maf": 0.0023, "KGP_genomes_AMR_maf": 0.0634, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.1054, "KGP_genomes_SAS_maf": 0.0143, "gnomad_maf": 0.06269, "gnomad_AFR_maf": 0.01409, "gnomad_AMR_maf": 0.05098, "gnomad_ASJ_maf": 0.1713, "gnomad_EAS_maf": 0.0006525, "gnomad_FIN_maf": 0.03934, "gnomad_NFE_maf": 0.08848, "gnomad_OTH_maf": 0.07918, "gnomad_SAS_maf": 0.02062, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Benign", "cadd_prediction": 0.151927, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 50757276, "genomic_position_hg38": 50723365, "chromosome": "16", "annotation_flag": null, "lastmodified": "2024-02-29T15:02:34.949154", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.2863G>A", "protein_change": "p.Val955Ile", "transcript_id": "NM_022162.3", "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 8 }, "data": [ { "type": "Combination", "id": "OLI1757" }, { "type": "Combination", "id": "OLI1758" }, { "type": "Combination", "id": "OLI1771" }, { "type": "Combination", "id": "OLI1772" }, { "type": "Combination", "id": "OLI1777" }, { "type": "Combination", "id": "OLI1778" }, { "type": "Combination", "id": "OLI1779" }, { "type": "Combination", "id": "OLI1784" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/3726/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/3726/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/3726/relationships/gene_name?format=api", "related": 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