Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/HFE/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "118",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Same pathway",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "Metabolic pathways",
                    "Metabolism of porphyrins",
                    "Heme biosynthesis",
                    "Metabolism"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:00:50.703347"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI167"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/118/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/118/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 3
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "HFE"
                        },
                        {
                            "type": "Gene",
                            "id": "HMBS"
                        },
                        {
                            "type": "Gene",
                            "id": "UROD"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/118/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/118/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/118/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "126",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype",
                    "Affecting the same tissue",
                    "Co-expression"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:00:51.254211"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI186"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI187"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/126/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/126/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "HAMP"
                        },
                        {
                            "type": "Gene",
                            "id": "HFE"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/126/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/126/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/126/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "723",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Monogenic experiments only"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 0,
                "lastmodified": "2024-03-01T14:58:59.212007"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI966"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/723/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/723/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "FIG4"
                        },
                        {
                            "type": "Gene",
                            "id": "GRN"
                        },
                        {
                            "type": "Gene",
                            "id": "HFE"
                        },
                        {
                            "type": "Gene",
                            "id": "SOD1"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/723/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/723/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/723/?format=api"
            }
        }
    ]
}