Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/TSHR/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "324", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Autoimmune thyroid disease", "Thyroid hormone synthesis" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:02.436479" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI471" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/324/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/324/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "TPO" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/324/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/324/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/324/?format=api" } }, { "type": "GeneCombination", "id": "360", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "Thyroid hormone synthesis", "Autoimmune thyroid disease" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:27.743323" }, "relationships": { "combination_set": { "meta": { "count": 3 }, "data": [ { "type": "Combination", "id": "OLI520" }, { "type": "Combination", "id": "OLI1073" }, { "type": "Combination", "id": "OLI1493" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/360/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/360/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "TG" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/360/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/360/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/360/?format=api" } }, { "type": "GeneCombination", "id": "392", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Disease", "Signal Transduction" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:06.042378" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI581" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/392/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/392/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "JAG1" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/392/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/392/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/392/?format=api" } }, { "type": "GeneCombination", "id": "396", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:06.202849" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI585" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/396/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/396/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "GLIS3" }, { "type": "Gene", "id": "SLC26A4" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/396/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/396/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/396/?format=api" } }, { "type": "GeneCombination", "id": "397", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Disease", "Autoimmune thyroid disease", "Thyroid hormone synthesis" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:06.248593" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI586" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/397/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/397/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "SLC26A4" }, { "type": "Gene", "id": "TPO" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/397/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/397/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/397/?format=api" } }, { "type": "GeneCombination", "id": "399", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:06.347193" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI589" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/399/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/399/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FOXE1" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/399/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/399/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/399/?format=api" } }, { "type": "GeneCombination", "id": "856", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Monogenic experiments only", "Affecting the same tissue", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Thyroid hormone synthesis" ], "genecomb_metascore": 1, "lastmodified": "2024-03-01T14:45:17.084092" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1174" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/856/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/856/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "DUOXA2" }, { "type": "Gene", "id": "TPO" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/856/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/856/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/856/?format=api" } }, { "type": "GeneCombination", "id": "359", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "Thyroid hormone synthesis" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:27.697101" }, "relationships": { "combination_set": { "meta": { "count": 13 }, "data": [ { "type": "Combination", "id": "OLI518" }, { "type": "Combination", "id": "OLI986" }, { "type": "Combination", "id": "OLI987" }, { "type": "Combination", "id": "OLI988" }, { "type": "Combination", "id": "OLI1074" }, { "type": "Combination", "id": "OLI1076" }, { "type": "Combination", "id": "OLI1175" }, { "type": "Combination", "id": "OLI1481" }, { "type": "Combination", "id": "OLI1482" }, { "type": "Combination", "id": "OLI1483" }, { "type": "Combination", "id": "OLI1485" }, { "type": "Combination", "id": "OLI1494" }, { "type": "Combination", "id": "OLI1806" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/359/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/359/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "DUOX2" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/359/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/359/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/359/?format=api" } }, { "type": "GeneCombination", "id": "793", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "Disease", "Thyroid hormone synthesis" ], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:27.747581" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI1075" }, { "type": "Combination", "id": "OLI1495" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/793/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/793/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "SLC26A4" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/793/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/793/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/793/?format=api" } }, { "type": "GeneCombination", "id": "798", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2023-05-16T12:03:27.774929" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI1081" }, { "type": "Combination", "id": "OLI1499" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/798/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/798/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "DUOX2" }, { "type": "Gene", "id": "NKX2-1" }, { "type": "Gene", "id": "TSHR" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/798/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/798/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/798/?format=api" } } ] }