Variant List
This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database
GET /api/genes/TSHR/variants/?format=api
{ "data": [ { "type": "SmallVariant", "id": "2144", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0004, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.001, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.001, "gnomad_maf": 0.0001393, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.001795, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 6.533e-05, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.399126, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 81609976, "genomic_position_hg38": 81143632, "chromosome": "14", "annotation_flag": "manually_attributed", "lastmodified": "2023-12-19T09:35:51.611932", "ref_allele": "T", "alt_allele": "C", "cdna_change": "c.1574T>C", "protein_change": "p.Phe525Ser", "transcript_id": "ENST00000298171.7", "dbsnp_id": "rs200138601", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 5 }, "data": [ { "type": "Combination", "id": "OLI1075" }, { "type": "Combination", "id": "OLI1174" }, { "type": "Combination", "id": "OLI1175" }, { "type": "Combination", "id": "OLI1806" }, { "type": "Combination", "id": "OLI987" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/2144/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/2144/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/2144/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/2144/gene/?format=api" }, "data": { "type": "Gene", "id": "TSHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/2144/?format=api" } }, { "type": "SmallVariant", "id": "1013", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.295074, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 81558933, "genomic_position_hg38": 81092589, "chromosome": "14", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:46.591053", "ref_allele": "T", "alt_allele": "C", "cdna_change": null, "protein_change": "p.Cys176Arg", "transcript_id": null, "dbsnp_id": "NA", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI471" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1013/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1013/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1013/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1013/gene/?format=api" }, "data": { "type": "Gene", "id": "TSHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1013/?format=api" } }, { "type": "SmallVariant", "id": "1014", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": null, "pp2_hvar_prediction": null, "cadd_prediction": 7.166276, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 81610254, "genomic_position_hg38": 81143910, "chromosome": "14", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:46.596989", "ref_allele": "A", "alt_allele": "T", "cdna_change": null, "protein_change": "p.Lys618Ter", "transcript_id": null, "dbsnp_id": "NA", "variant_effect": "nonsense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI471" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1014/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1014/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1014/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1014/gene/?format=api" }, "data": { "type": "Gene", "id": "TSHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1014/?format=api" } }, { "type": "SmallVariant", "id": "1099", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 3.986e-06, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 8.795e-06, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.637429, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 81609918, "genomic_position_hg38": 81143574, "chromosome": "14", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:47.125559", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.1516G>A", "protein_change": "p.Glu506Lys", "transcript_id": "NM_000369.2", "dbsnp_id": "rs762048531", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI518" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1099/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1099/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1099/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1099/gene/?format=api" }, "data": { "type": "Gene", "id": "TSHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1099/?format=api" } }, { "type": "SmallVariant", "id": "1103", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 2.785e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 6.156e-05, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": null, "pp2_hvar_prediction": null, "cadd_prediction": 3.051952, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 81574796, "genomic_position_hg38": 81108452, "chromosome": "14", "annotation_flag": "manually_attributed", "lastmodified": "2023-06-06T16:57:47.150170", "ref_allele": "TGTGA", "alt_allele": "T", "cdna_change": "c.692+1_692+4delGTGA", "protein_change": null, "transcript_id": "NM_000369", "dbsnp_id": "rs771577188", "variant_effect": "splicing" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI520" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1103/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1103/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1103/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1103/gene/?format=api" }, "data": { "type": "Gene", "id": "TSHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1103/?format=api" } }, { "type": "SmallVariant", "id": "1230", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.78388, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 81610086, "genomic_position_hg38": 81143742, "chromosome": "14", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:47.898154", "ref_allele": "A", "alt_allele": "G", "cdna_change": null, "protein_change": "p.Ser562Gly", "transcript_id": null, "dbsnp_id": "NA", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI581" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1230/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1230/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1230/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1230/gene/?format=api" }, "data": { "type": "Gene", "id": "TSHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1230/?format=api" } }, { "type": "SmallVariant", "id": "1240", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.696382, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 81610320, "genomic_position_hg38": 81143976, "chromosome": "14", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:47.952833", "ref_allele": "A", "alt_allele": "C", "cdna_change": null, "protein_change": "p.Ile640Leu", "transcript_id": null, "dbsnp_id": "NA", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI585" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1240/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1240/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1240/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1240/gene/?format=api" }, "data": { "type": "Gene", "id": "TSHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1240/?format=api" } }, { "type": "SmallVariant", "id": "1241", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 1.592e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 2.892e-05, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 5.442e-05, "gnomad_FIN_maf": 4.656e-05, "gnomad_NFE_maf": 8.796e-06, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 4.238553, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 81609958, "genomic_position_hg38": 81143614, "chromosome": "14", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:47.958917", "ref_allele": "G", "alt_allele": "A", "cdna_change": null, "protein_change": "p.Arg519His", "transcript_id": null, "dbsnp_id": "rs780018604", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI585" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1241/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1241/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1241/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1241/gene/?format=api" }, "data": { "type": "Gene", "id": "TSHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1241/?format=api" } }, { "type": "SmallVariant", "id": "1245", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0004, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.001, "KGP_genomes_EUR_maf": 0.001, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.0001432, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 8.678e-05, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0001087, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0002639, "gnomad_OTH_maf": 0.0001631, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.0002326 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 2.267825, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 81558891, "genomic_position_hg38": 81092547, "chromosome": "14", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:47.983205", "ref_allele": "C", "alt_allele": "G", "cdna_change": null, "protein_change": "p.Pro162Ala", "transcript_id": null, "dbsnp_id": "rs121908863", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI586" }, { "type": "Combination", "id": "OLI589" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1245/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1245/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1245/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/1245/gene/?format=api" }, "data": { "type": "Gene", "id": "TSHR" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/1245/?format=api" } }, { "type": "SmallVariant", "id": "1250", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0002, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0014, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 1.989e-05, "gnomad_AFR_maf": 6.152e-05, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 3.518e-05, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.0001163 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.775512, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 81554306, "genomic_position_hg38": 81087962, "chromosome": "14", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:48.007403", "ref_allele": "G", "alt_allele": "A", "cdna_change": null, "protein_change": "p.Arg109Gln", "transcript_id": null, "dbsnp_id": "rs121908865", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI589" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/1250/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/1250/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/1250/relationships/gene_name?format=api", "related": 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