GENE NAME | PDE3A |
CHROMOSOME | 12 |
ENSEMBL ID | ENSG00000172572 |
ENTREZ ID | 5139 |
UNIPROT ACCESSION NUMBER | Q14432 |
GO MOLECULAR FUNCTION | protein binding; hydrolase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding |
ESSENTIAL IN MOUSE | Non-essential |
PATHWAYS | R-HSA-418555; hsa04022; hsa01100; hsa04024; hsa00230; R-HSA-388396; hsa04924; hsa05032; R-HSA-162582; R-HSA-372790 |
1 combination linked to PDE3A | OLI425 |
1 variant linked to PDE3A | PDE3A:c.1477G>A, p.Gly493Arg |
1 disease linked to PDE3A | Normosmic congenital hypogonadotropic hypogonadism |