Details for Gene PDE3A

GENE NAME PDE3A
CHROMOSOME 12
ENSEMBL ID ENSG00000172572
ENTREZ ID 5139
UNIPROT ACCESSION NUMBER Q14432
GO MOLECULAR FUNCTION protein binding; hydrolase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding
ESSENTIAL IN MOUSE Non-essential
PATHWAYS R-HSA-418555; hsa04022; hsa01100; hsa04024; hsa00230; R-HSA-388396; hsa04924; hsa05032; R-HSA-162582; R-HSA-372790
1 combination linked to PDE3A OLI425
1 variant linked to PDE3A PDE3A:c.1477G>A, p.Gly493Arg
1 disease linked to PDE3A Normosmic congenital hypogonadotropic hypogonadism

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